Sepsisli çocuklarda trombozu etkileyen genlerdeki polimorfizmlerin değerlendirilmesi

Cilt: 48 Sayı: 2 1 Haziran 2009
  • Cogulu O
  • Onay H
  • Gunduz C
  • Ekmekci A
  • Atlihan F
  • Ozkinay F
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Evaluation of the polymorphisms of genes affecting thrombosis throughout sepsis in children

Abstract

Aim: Since the clinical course of sepsis exhibits individual variance, its genetic background and the polymorphisms found in the genes which may be responsible for the predisposition to sepsis have been investigated. The interaction between coagulation and sepsis has directed researchers to investigate the genetic polymorphisms of those factors. We aimed to determine the polymorphisms of Factor V Leiden, Factor V 1299, prothrombin, Factor XIII, beta-fibrinogen, plasminogen activator inhibitor 1, glycoprotein III, MTHFR, Apo E in children with sepsis and septic shock. Material and Methods: Ninety-two children with sepsis and ninety-two healthy children were included into the study by using a reverse-hybridization assay. Among the study group 20 cases developed septic shock (10 of nonsurvivors was in the septic shock group, 4 in the sepsis group). Results: Among the sepsis group, a total of 16 cases had (17.4 %) positive blood cultures. The microorganisms were Pseudomonas aeruginosa in 7 cases (43.7 %), Klebsiella pneumoniae in 3 (18.7 %), Eschherichia coli in 2 (12.5 %), Streptococcus pneumonia in 2 (12.5 %), Enterococcus faecalis in 1 (6.3 %) and Candida albicans in 1 (6.3 %). No statistically significant difference associated with all the polymorphisms between the groups of sepsis, septic shock and nonsurvivors compared to healthy group was achieved. Conclusion: The polymorphisms investigated in the proteins having a role in the thrombosis process were not found to have a significant effect on the incidence of developing sepsis or outcome of sepsis in children.

Keywords

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Cogulu O

Onay H

Gunduz C

Ekmekci A

Atlihan F

Ozkinay F

Yayımlanma Tarihi

1 Haziran 2009

Gönderilme Tarihi

1 Haziran 2009

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2009 Cilt: 48 Sayı: 2

IZ

https://izlik.org/JA97KM27GG

Kaynak Göster

RIS / Bibtex
Vancouver
1.Cogulu O, Onay H, Gunduz C, Ekmekci A, Atlihan F, Ozkinay F. Sepsisli çocuklarda trombozu etkileyen genlerdeki polimorfizmlerin değerlendirilmesi. ETD [Internet]. 01 Haziran 2009;48(2):77-83. Erişim adresi: https://izlik.org/JA97KM27GG

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