Retrospective analysis of the outcome of pediatric lupus nephritis, single center study

Volume: 48 Number: 3 September 1, 2009
  • Sozeri B
  • Mir S
  • Mutlubas F
  • En S
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Retrospective analysis of the outcome of pediatric lupus nephritis, single center study

Abstract

Aim: We aim to analyse in this study was outcome results and therapy modalities in patients with lupus nephritis. Materials and Methods: We performed a retrospective cohort study of our 37 lupus patients, diagnosed and treated between1986-2006. Conclusions: The mean age at onset of disease was 13 ± 2.2 years. Renal involvement was present in 26 (70.2%) of the patients. At the time of the initial biopsy, proteinuria was observed in 15 (57.7%) patients, and it was within nephrotic range in 4 (15.3%) patients. 11 (42.3%) patients had hematuria, 7 (26.9%) had hypertension, and 6 (23%) had impaired renal function. The most frequent histopathological finding was class II (42.3%), followed by class IV (30.7%), class III (15.3%) and class I (11.7%) lupus nephritis (LN). All patients with class IV lupus nephritis had a significant tendency for developing hypertension (p=0.006) and nephrotic range proteinuria (p=0.004). 57% of patients with lupus nephritis had remission, 30% of them still had active disease. Result: Finally, the prognosis of children with LN depends primarily on the severity of histopathological lesions.

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Primary Language

Turkish

Subjects

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Journal Section

-

Authors

Sozeri B

Mir S

Mutlubas F

En S

Publication Date

September 1, 2009

Submission Date

September 1, 2009

Acceptance Date

-

Published in Issue

Year 2009 Volume: 48 Number: 3

IZ

https://izlik.org/JA72NF95UK

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1.Sozeri B, Mir S, Mutlubas F, En S. Pediatrik lupus nefritinin retrospektif izlem sonuçları, tek merkez çalışması. EJM [Internet]. 2009 Sep. 1;48(3):181-7. Available from: https://izlik.org/JA72NF95UK

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