Meta-analiz: Türk Toplumunda MTHFR c.677C>T polimorfizmi ve kanser ilişkisi

Çetintaş V B; Avcı Ç B; Süslüer S Y; Eroğlu Z; Gündüz C

EN TR

Meta-analysis: Association between MTHFR c.677C>T polymorphism and cancer in the Turkish population

Abstract

Global DNA hypomethylation associates with hyperhomocysteinemia, MTHFR c.677C>T homozygosity and the development of cancer. Aim: The aim of this study was to investigate the relationship of the MTHFR c.677C>T polymorphism with the risk of cancer in the Turkish population via meta-analysis. Materials and Methods: Studies were identified by searching electronic literature, focusing on the key words; Turkish population, MTHFR C677T and the risk of cancer. All data were analyzed using STATA software. Odds ratio (OR) and 95% confidence interval (Cl) values were calculated using the Mantel-Haentzel statistic according to fixed-effect model. Results: Odds ratio values for Recessive (CC+CT vs TT), Homozygous (CC vs TT) and Dominant (CC vs CT+TT) genetic models were calculated as 1.24 (95% CI: 1.013-1.524), 1.14 (95% CI: 0.93-1.41) and 0.97 (95% CI: 0.869-1.090), respectively. The risk of cancer increased significantly in the TT genotype (p=0.043). Conclusion: Our results support the finding that MTHFR c.677C>T polymorphism is a potential biomarker for cancer risk in the Turkish population.

Keywords

MTHFR c.677C>T, polymorphism, cancer, meta-analysis

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Çetintaş V B

Avcı Ç B

Süslüer S Y

Eroğlu Z

Gündüz C

Publication Date

December 1, 2012

Submission Date

December 1, 2012

Acceptance Date

-

Published in Issue

Year 2012 Volume: 51 Number: 4

IZ

https://izlik.org/JA65WE44HX

Cite

RIS / Bibtex

APA

B, Ç. V., B, A. Ç., Y, S. S., Z, E., & C, G. (2012). Meta-analiz: Türk Toplumunda MTHFR c.677C>T polimorfizmi ve kanser ilişkisi. Ege Tıp Dergisi, 51(4), 221-228. https://izlik.org/JA65WE44HX

AMA

1.B ÇV, B AÇ, Y SS, Z E, C G. Meta-analiz: Türk Toplumunda MTHFR c.677C>T polimorfizmi ve kanser ilişkisi. EJM. 2012;51(4):221-228. https://izlik.org/JA65WE44HX

Chicago

B, Çetintaş V, Avcı Ç B, Süslüer S Y, Eroğlu Z, and Gündüz C. 2012. “Meta-Analiz: Türk Toplumunda MTHFR C.677C>T Polimorfizmi Ve Kanser Ilişkisi”. Ege Tıp Dergisi 51 (4): 221-28. https://izlik.org/JA65WE44HX.

EndNote

B ÇV, B AÇ, Y SS, Z E, C G (December 1, 2012) Meta-analiz: Türk Toplumunda MTHFR c.677C>T polimorfizmi ve kanser ilişkisi. Ege Tıp Dergisi 51 4 221–228.

IEEE

[1]Ç. V. B, A. Ç. B, S. S. Y, E. Z, and G. C, “Meta-analiz: Türk Toplumunda MTHFR c.677C>T polimorfizmi ve kanser ilişkisi”, EJM, vol. 51, no. 4, pp. 221–228, Dec. 2012, [Online]. Available: https://izlik.org/JA65WE44HX

ISNAD

B, Çetintaş V - B, Avcı Ç - Y, Süslüer S - Z, Eroğlu - C, Gündüz. “Meta-Analiz: Türk Toplumunda MTHFR C.677C>T Polimorfizmi Ve Kanser Ilişkisi”. Ege Tıp Dergisi 51/4 (December 1, 2012): 221-228. https://izlik.org/JA65WE44HX.

JAMA

1.B ÇV, B AÇ, Y SS, Z E, C G. Meta-analiz: Türk Toplumunda MTHFR c.677C>T polimorfizmi ve kanser ilişkisi. EJM. 2012;51:221–228.

MLA

B, Çetintaş V, et al. “Meta-Analiz: Türk Toplumunda MTHFR C.677C>T Polimorfizmi Ve Kanser Ilişkisi”. Ege Tıp Dergisi, vol. 51, no. 4, Dec. 2012, pp. 221-8, https://izlik.org/JA65WE44HX.

Vancouver

1.Çetintaş V B, Avcı Ç B, Süslüer S Y, Eroğlu Z, Gündüz C. Meta-analiz: Türk Toplumunda MTHFR c.677C>T polimorfizmi ve kanser ilişkisi. EJM [Internet]. 2012 Dec. 1;51(4):221-8. Available from: https://izlik.org/JA65WE44HX