Generalized myasthenia gravis following use of D-penicillamine in a patient with Wilson's disease

Volume: 52 Number: 4 December 1, 2013
  • Yiğiter R
  • Elçi M A
  • Kçalı A
  • Altunışık E
  • Demir F
  • Neyal M
Ege Journal of Medicine Cover
Ege Journal of Medicine
PDF Download
EN TR

Generalized myasthenia gravis following use of D-penicillamine in a patient with Wilson's disease

Abstract

Wilson's disease is an autosomal recessive disease seen in later childhood or young adulthood which is caused by an accumulation of copper in tissues which leads to hepatic, neurological, psychiatric symptoms or a combination of these. A copper chelator agent called D-penicillamine, which is being widely used with other drugs for Wilson's disease, increases copper excretion in urine. Myasthenia gravis is an autoimmune disorder of the neuromuscular junction causing muscle weakness and fatigue. It is known that some drugs such as D-penicillamine can effect the neuromuscular junction and worsen the clinical results of patients. D-penicillamine was given to an 18-year-old female patient with Wilson's disease. The patient was admitted to our clinic with complaints of generalized weakness for three months and after the physical examination and laboratory findings we diagnosed her as having myasthenia gravis secondary to drugs. We have found it significant to present the case that some medicines used in clinical diseases may cause another clinical case. And if an unexpected clinical process develops, the medicines in use may need to be reconsidered.

Keywords

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Yiğiter R

Elçi M A

Kçalı A

Altunışık E

Demir F

Neyal M

Publication Date

December 1, 2013

Submission Date

December 1, 2013

Acceptance Date

-

Published in Issue

Year 1970 Volume: 52 Number: 4

IZ

https://izlik.org/JA68BS22CS

Cite

RIS / Bibtex
Vancouver
1.Yiğiter R, Elçi M A, Kçalı A, Altunışık E, Demir F, Neyal M. Wilson hastalığı bulunan bir hastada D-penisilamin tedavisi sonucu ortaya çıkan jeneralize miyastenia gravis. EJM [Internet]. 2013 Dec. 1;52(4):217-9. Available from: https://izlik.org/JA68BS22CS

Ege Journal of Medicine enables the sharing of articles according to the Attribution-Non-Commercial-Share Alike 4.0 International (CC BY-NC-SA 4.0) license.