Determination of the association between the C677T and A1298C polymorphisms of the MTHFR gene and the development risk of azoospermia and oligozoospermia in Turkish infertile men

Volume: 53 Number: 3 September 1, 2014
  • Vardarlı A T
  • Bozok Cetintas V
  • Eroglu Z
  • Semerci B
  • Ulukus M
  • Tavmergen E
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Determination of the association between the C677T and A1298C polymorphisms of the MTHFR gene and the development risk of azoospermia and oligozoospermia in Turkish infertile men

Abstract

Aim: We aimed to investigate the relationship between unexplained male infertility, and the -677C/T (rs1801133) and -1298A/C (rs1801131) polymorphisms of the MTHFR gene in a group of Turkish infertile men with non-obstructive azoospermia and severe oligozoospermia in this study. Materials and Methods: Study group includes 50 non-obstructive azoospermic patients, 50 severe oligospermic patients and 50 healthy controls with normal sperm parameters who had had more than one child. Genotyping was performed by generated amplicons from melting curve analysis after real time PCR. Results: The distribution of the 677CC genotype was significantly higher in the control group than the infertile group (p= 0.046). There was a significant frequency of the polymorphic T allele in infertile patients higher than the control group (p=0.015). Neither the frequency, nor the allelic distribution of A1298C genotype was different between infertile groups compared with the control. Conclusions: The MTHFR 677TT genotype is a genetic risk factor for unexplained male infertility, especially in the group with oligospermia and non-obstructive azoospermia.

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Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Vardarlı A T

Bozok Cetintas V

Eroglu Z

Semerci B

Ulukus M

Tavmergen E

Publication Date

September 1, 2014

Submission Date

September 1, 2014

Acceptance Date

-

Published in Issue

Year 1970 Volume: 53 Number: 3

DOI

https://doi.org/10.19161/etd.344070

IZ

https://izlik.org/JA78CU93RU

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1.Vardarlı A T, Bozok Cetintas V, Eroglu Z, Semerci B, Ulukus M, Tavmergen E. İnfertil Türk erkeklerinde MTHFR genindeki C677T ve A1298C polimorfizmlerinin azosperm ve oligosperm gelişim riski üzerindeki etkisinin araştırılması. EJM. 2014 Sep. 1;53(3):124-8. doi:10.19161/etd.344070

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