İnfertil Türk erkeklerinde MTHFR genindeki C677T ve A1298C polimorfizmlerinin azosperm ve oligosperm gelişim riski üzerindeki etkisinin araştırılması

Cilt: 53 Sayı: 3 1 Eylül 2014
  • Vardarlı A T
  • Bozok Cetintas V
  • Eroglu Z
  • Semerci B
  • Ulukus M
  • Tavmergen E
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Determination of the association between the C677T and A1298C polymorphisms of the MTHFR gene and the development risk of azoospermia and oligozoospermia in Turkish infertile men

Abstract

Aim: We aimed to investigate the relationship between unexplained male infertility, and the -677C/T (rs1801133) and -1298A/C (rs1801131) polymorphisms of the MTHFR gene in a group of Turkish infertile men with non-obstructive azoospermia and severe oligozoospermia in this study. Materials and Methods: Study group includes 50 non-obstructive azoospermic patients, 50 severe oligospermic patients and 50 healthy controls with normal sperm parameters who had had more than one child. Genotyping was performed by generated amplicons from melting curve analysis after real time PCR. Results: The distribution of the 677CC genotype was significantly higher in the control group than the infertile group (p= 0.046). There was a significant frequency of the polymorphic T allele in infertile patients higher than the control group (p=0.015). Neither the frequency, nor the allelic distribution of A1298C genotype was different between infertile groups compared with the control. Conclusions: The MTHFR 677TT genotype is a genetic risk factor for unexplained male infertility, especially in the group with oligospermia and non-obstructive azoospermia.

Keywords

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Vardarlı A T

Bozok Cetintas V

Eroglu Z

Semerci B

Ulukus M

Tavmergen E

Yayımlanma Tarihi

1 Eylül 2014

Gönderilme Tarihi

1 Eylül 2014

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 1970 Cilt: 53 Sayı: 3

DOI

https://doi.org/10.19161/etd.344070

IZ

https://izlik.org/JA78CU93RU

Kaynak Göster

RIS / Bibtex
Vancouver
1.Vardarlı A T, Bozok Cetintas V, Eroglu Z, Semerci B, Ulukus M, Tavmergen E. İnfertil Türk erkeklerinde MTHFR genindeki C677T ve A1298C polimorfizmlerinin azosperm ve oligosperm gelişim riski üzerindeki etkisinin araştırılması. ETD. 01 Eylül 2014;53(3):124-8. doi:10.19161/etd.344070

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