Correlation of mid-trimester homocysteine, vitamin B12 and folate levels with adverse pregnancy outcomes: A clinical study

Volume: 54 Number: 2 June 1, 2015
  • Ulku Mete Ural
  • Ayse Filiz Avsar
  • Nuri Danısman
  • Pınar Caglar Aytac
  • Baran Altuakar
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Correlation of mid-trimester homocysteine, vitamin B12 and folate levels with adverse pregnancy outcomes: A clinical study

Abstract

Aim: The aim of this study is to determine if maternal serum levels of folate, vitamin B12 and homocysteine at 20-26 weeks of gestation are associated with subsequent adverse pregnancy outcomes. Materials and Methods: This prospective study was conducted in a tertiary care center and included 159 pregnant women at 20-26 gestational weeks. Complicated and uncomplicated pregnancy groups were compared in terms of serum levels of folate, vitamin B12, and homocysteine using Mann-Whitney U and t tests. Correlation of homocysteine with vitamin B12 and folate were analyzed with regression analysis. Results: Of the 159 participants, 32 (20.13%) suffered from pregnancy complications. There were no significant differences in the levels of the midtrimester homocysteine (p=0.25) and vitamin B12 (p=0.19) between healthy and complicated pregnancy groups. The significant difference in terms of folate levels (p=0.02) was considered to be clinically insignificant, since the measured levels were within normal range. There is a statistically significant inverse correlation between homocysteine and vitamin B12 levels (r = -0.407, p=0.013). Conclusion: Our results indicate that homocysteine, vitamin B12 and folate concentrations in mid-trimester are not associated with adverse pregnancy outcomes. These findings suggest that these markers seem not to have predictive value for pregnancy complications.

Keywords

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Ulku Mete Ural

Ayse Filiz Avsar

Nuri Danısman

Pınar Caglar Aytac

Baran Altuakar

Publication Date

June 1, 2015

Submission Date

June 1, 2015

Acceptance Date

-

Published in Issue

Year 2015 Volume: 54 Number: 2

DOI

https://doi.org/10.19161/etd.344116

IZ

https://izlik.org/JA95LG63DD

Cite

RIS / Bibtex
APA
Ural, U. M., Avsar, A. F., Danısman, N., Aytac, P. C., & Altuakar, B. (2015). İkinci trimester homosistein, B12 vitamini ve folat düzeylerinin olumsuz obstetrik sonuçlarla ilişkisi: Klinik çalışma. Ege Tıp Dergisi, 54(2), 78-82. https://doi.org/10.19161/etd.344116
AMA
1.Ural UM, Avsar AF, Danısman N, Aytac PC, Altuakar B. İkinci trimester homosistein, B12 vitamini ve folat düzeylerinin olumsuz obstetrik sonuçlarla ilişkisi: Klinik çalışma. EJM. 2015;54(2):78-82. doi:10.19161/etd.344116
Chicago
Ural, Ulku Mete, Ayse Filiz Avsar, Nuri Danısman, Pınar Caglar Aytac, and Baran Altuakar. 2015. “İkinci Trimester Homosistein, B12 Vitamini Ve Folat Düzeylerinin Olumsuz Obstetrik Sonuçlarla Ilişkisi: Klinik çalışma”. Ege Tıp Dergisi 54 (2): 78-82. https://doi.org/10.19161/etd.344116.
EndNote
Ural UM, Avsar AF, Danısman N, Aytac PC, Altuakar B (June 1, 2015) İkinci trimester homosistein, B12 vitamini ve folat düzeylerinin olumsuz obstetrik sonuçlarla ilişkisi: Klinik çalışma. Ege Tıp Dergisi 54 2 78–82.
IEEE
[1]U. M. Ural, A. F. Avsar, N. Danısman, P. C. Aytac, and B. Altuakar, “İkinci trimester homosistein, B12 vitamini ve folat düzeylerinin olumsuz obstetrik sonuçlarla ilişkisi: Klinik çalışma”, EJM, vol. 54, no. 2, pp. 78–82, June 2015, doi: 10.19161/etd.344116.
ISNAD
Ural, Ulku Mete - Avsar, Ayse Filiz - Danısman, Nuri - Aytac, Pınar Caglar - Altuakar, Baran. “İkinci Trimester Homosistein, B12 Vitamini Ve Folat Düzeylerinin Olumsuz Obstetrik Sonuçlarla Ilişkisi: Klinik çalışma”. Ege Tıp Dergisi 54/2 (June 1, 2015): 78-82. https://doi.org/10.19161/etd.344116.
JAMA
1.Ural UM, Avsar AF, Danısman N, Aytac PC, Altuakar B. İkinci trimester homosistein, B12 vitamini ve folat düzeylerinin olumsuz obstetrik sonuçlarla ilişkisi: Klinik çalışma. EJM. 2015;54:78–82.
MLA
Ural, Ulku Mete, et al. “İkinci Trimester Homosistein, B12 Vitamini Ve Folat Düzeylerinin Olumsuz Obstetrik Sonuçlarla Ilişkisi: Klinik çalışma”. Ege Tıp Dergisi, vol. 54, no. 2, June 2015, pp. 78-82, doi:10.19161/etd.344116.
Vancouver
1.Ulku Mete Ural, Ayse Filiz Avsar, Nuri Danısman, Pınar Caglar Aytac, Baran Altuakar. İkinci trimester homosistein, B12 vitamini ve folat düzeylerinin olumsuz obstetrik sonuçlarla ilişkisi: Klinik çalışma. EJM. 2015 Jun. 1;54(2):78-82. doi:10.19161/etd.344116

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