Kanserde yeni bir hedef haline gelen çok yönlü Sox2 geni

İrem Doğan Turaçlı; Abdullah Ekmekçi

doi:10.19161/etd.344193

EN TR

Multifunctional Sox2 gene which turns out a new target in cancer

Abstract

Sox2 protein is a transcription factor which is important for the maintenance and regulation of the permanence of undifferentiated embryonic and adult stem cells. Like the other pluripotency factors, Sox2 can be regulated by post-transcriptional and post-translational modifications which affect its binding ability to DNA. Sox2 involves in many cellular events in the initiation and progression of tumorigenesis such as proliferation of cancer cells, invasion, migration, metastasis, maintenance of stem like state of cancer stem cells, cellular programming, apoptosis and chemoresistance. Although there is a confliction, it is generally accepted Sox2 is an anti-apoptotic factor in cancer cells. In this review, we discuss the roles of Sox2 in the presence of cell stemness, differantiation and signal transduction. Also, we underline its multifunctionality with discussing Sox2 gaining oncogenic properties by amplification therefore having the potential to be used as a molecular target.

Keywords

Sox2, cancer

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

İrem Doğan Turaçlı

Abdullah Ekmekçi

Publication Date

June 1, 2016

Submission Date

June 1, 2016

Acceptance Date

-

Published in Issue

Year 2016 Volume: 55 Number: 2

DOI

https://doi.org/10.19161/etd.344193

IZ

https://izlik.org/JA79GG87MF

Cite

RIS / Bibtex

Vancouver

1.İrem Doğan Turaçlı, Abdullah Ekmekçi. Kanserde yeni bir hedef haline gelen çok yönlü Sox2 geni. EJM. 2016 Jun. 1;55(2):98-103. doi:10.19161/etd.344193

Multifunctional Sox2 gene which turns out a new target in cancer

Multifunctional Sox2 gene which turns out a new target in cancer

Abstract

Keywords