Evaluation of 'anti-HBc only' serological pattern detected in patients admitted to Ege University Hospital

Volume: 55 Number: 4 December 1, 2016
  • Tuğba Bozdemir
  • Ayşın Zeytinoğlu Türkeş
  • Rüçhan Sertöz
  • İmre Altuğlu
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Evaluation of 'anti-HBc only' serological pattern detected in patients admitted to Ege University Hospital

Abstract

Aim: The aim of the study is to determine the prevalance of serological pattern 'anti-HBc alone' in samples of patients sent to Ege University Virology Laboratory for the determination of hepatitis B markers and to determine the HBV DNA presence and co-infections in these samples. Materials and Methods: The results of 22333 serum samples tested between January 2014-December 2014 were examined retrospectively. HBV, HCV, HIV markers were tested with chemiluminescent microparticle immunoassay (CMIA) (Architect i2000sr, Abbott, USA) and HBV DNA with Real time PCR (Abbott m2000rt, Abbott, U.S.A.). Results: Eight hundred and thirty-seven (%3.74) of 22333 samples were determined as having the serological pattern 'anti-HBc alone'. Forty five of 808 samples tested for anti HCV were reactive and three samples out of 635 tested for anti HIV had reactive results. One hundred and eighty samples were tested for HBV DNA and 16 (%8.8) were found to be positive. Conclusion: 'Anti-HBc alone' serological profile is a common laboratory finding that is observed during routine serological assays in the clinical laboratory and %3.74 of 22333 samples were determined as having this serological pattern in our laboratory. This profile may reflect different situations from false reactivity to chronic HBV infections. Further testing and careful follow up is necessary in these patients.

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Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Tuğba Bozdemir

Ayşın Zeytinoğlu Türkeş

Rüçhan Sertöz

İmre Altuğlu

Publication Date

December 1, 2016

Submission Date

December 1, 2016

Acceptance Date

-

Published in Issue

Year 2016 Volume: 55 Number: 4

DOI

https://doi.org/10.19161/etd.344222

IZ

https://izlik.org/JA27JE92RU

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RIS / Bibtex
Vancouver
1.Tuğba Bozdemir, Ayşın Zeytinoğlu Türkeş, Rüçhan Sertöz, İmre Altuğlu. Ege Üniversitesi Hastanesine başvuran hastalarda saptanan izole anti-HBc pozitifliğinin değerlendirilmesi. EJM. 2016 Dec. 1;55(4):180-3. doi:10.19161/etd.344222

Cited By

Evaluation of Isolated Anti-HBc Positivity in Patients Considered for Hepatitis B Diagnosis: 8.5 Years of Data

Jundishapur Journal of Microbiology

https://doi.org/10.5812/jjm-154441

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