Osteopontin levels do not increase in gestational diabetes mellitus

Ali Saklamaz; Muhittin Akyıldız; Esin Kasap; Hakan Cengiz

doi:10.19161/etd.395216

EN TR

Osteopontin levels do not increase in gestational diabetes mellitus

Abstract

Aim: Osteopontin (OPN) has recently been considered as a marker of coronary artery disease. The aim of this study is to evaluate OPN levels and investigate their correlation with the high sensitivity-CRP (hs-CRP) levels in patients with gestational diabetes mellitus (GDM), an increased state of insulin resistance.

Materials and Methods: Fifty-four GDM patients and 40 healthy pregnant patients were included in this study. Biochemical tests for lipid profile, fasting blood glucose, oral glucose tolerance test, OPN, HOMA-IR and hs-CRP were done at 24th gestational week. Serum levels of OPN were measured by enzyme-linked immunosorbent assays (ELISAs), serum hs-CRP levels were measured by particle association turbidometric assay.

Results: Gestational week, age, BMI of two groups were similar (p > 0.05). The GDM group had significantly higher fasting, and post-load (1st and 2nd hour) blood glucose, HbA1c, fasting insulin and HOMA-IR levels than those of the healthy group. Except triglyceride levels, the lipid profiles of two groups were not significantly different. The GDM group had higher triglyceride levels than the control group (p<0.05). The OPN levels were 3.6±2.2 ng/mL in the GDM and 3.4±2.6 ng/mL in the control groups (p>0.05). The hs-CRP levels were 0.94±0.8 mg/dL, 0.57±0.5 mg/dL in the GDM and control groups, respectively (p<0.05). There was no correlation between the OPN and hs-CRP levels (r=0.080; p=0.442). In GDM the patients are experiencing rapid metabolic changes, so these metabolic changes may not affect the level of OPN.

Conclusion: OPN levels were not significantly increased in GDM patients.

Keywords

Gestasyonel diabetes mellitus,HOMA-IR,hs-CRP,osteopontin

Gestasyonel diabetes mellitusta osteopontin seviyeleri artmaz

Öz

Amaç: Osteopontin (OPN) son zamanlarda koroner arter hastalığının bir belirteci olarak düşünülmektedir. Bu çalışmada, insulin direncinin arttığı bir durum olan gestasyonel diabetes mellituslu (GDM) hastalarda,OPN seviyelerini ve bunun sensitif CRP (hs-CRP) seviyeleri ile korelasyonunu incelemek istedik.

Gereç ve Yöntem: Çalışmaya 54 GDM ve 40 sağlıklı hamile alındı. 24. Gebelik haftasında kan lipid düzeyleri, oral glukoz yükleme testi, OPN, HOMA-IR, hs-CRP düzeyleri için kan tahlilleri yapıldı. Serum OPN düzeyleri ELISA, hs-CRP düzeyleri parçacık ilişkili turbidimetrik test ile ölçüldü.

Bulgular: Her iki grubun gestasyonel haftası, yaş, VKI benzerdi (p > 0.05). GDM grubunda açlık glukoz, OGTT te 1 ve 2. saat kan glukoz, HbA1c, açlık insulin, HOMA-IR değerleri kontrol grubuna göre istatistiksel olarak anlamlı daha yüksek saptandı. Trigliserid seviyeleri dışında lipid profilerinde her iki grupta anlamlı fark saptanmadı. GDM grubunda kontrol grubuna göre trigliserid seviyeleri daha yüksek saptandı (p<0.05). GDM grubunda OPN seviyesi 3.6±2.2 ng/mL, kontrol grubunda 3.4±2.6 ng/mL saptandı (p>0.05). GDM ve kontrol gruplarında hs-CRP seviyeleri sırasıyla 0.94±0.8 mg/dL, 0.57±0.5 mg/dL saptandı (p<0.05). OPN ve hs-CRP seviyelerinde anlamlı korelasyon saptanmadı (r=0.080; p=0.442). Gestasyonel diyabette hastalar hızlı metabolik değişiklikler yaşadığı için metabolik değişiklikler OPN seviyesini etkilemeyebilir.

Sonuç: GDM’lu hastalarda OPN seviyelerinde anlamlı artış saptanmamıştır.

Anahtar Kelimeler

Gestational diabetes mellitus,HOMA-IR,hs-CRP,osteopontin

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Ali Saklamaz ^*
İzmir Medical Park Hospital, Clinic of Endocrinology and Metabolism, İzmir
0000-0001-9190-2242
Türkiye

Muhittin Akyıldız
Salihli Private Hospital, Clinic of Biochemistry, Manisa
0000-0001-6222-9917
Türkiye

Esin Kasap
İzmir Private Hayat Hospital, Clinic of Gynecology and Obstetrics, İzmir
0000-0002-1719-4257
Türkiye

Hakan Cengiz
Dokuz Eylül University, Institute of Health Sciences, Department of Molecular Medicine, İzmir
0000-0002-0868-0499
Türkiye

Publication Date

December 1, 2017

Submission Date

August 25, 2016

Acceptance Date

November 15, 2016

Published in Issue

Year 2017 Volume: 56 Number: 4

DOI

https://doi.org/10.19161/etd.395216

IZ

https://izlik.org/JA34LU39RN

Cite

RIS / Bibtex

Vancouver

1.Ali Saklamaz, Muhittin Akyıldız, Esin Kasap, Hakan Cengiz. Osteopontin levels do not increase in gestational diabetes mellitus. EJM. 2017 Dec. 1;56(4):173-7. doi:10.19161/etd.395216

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https://doi.org/10.3390/nu16244334