Treatment of contact burn injury with hypericum perforatum: An experimental study

Derya Cabbaroğlu; Meltem Songür Kodik; Yiğit Uyanıkgil; Emel Öykü Çetin Uyanıkgil; Fatih Karabey; Selahattin Kıyan

doi:10.19161/etd.512502

EN TR

Treatment of contact burn injury with hypericum perforatum: An experimental study

Abstract

Aim: Burns are one of the most difficult physical and psychological traumas that people face. Generally, protection and prevention strategies from burns are practiced. The young and the elderly are most likely to be affected tragically. The aim of the present study is to investigate the effect of Hypericum perforatum methanol extractcontaining gel on the healing of burn wounds.

Materials and Methods: Forty male rats of the Sprague-Dawley strain were divided into four groups after a 4x4 area of their back was shaved, and an experimental burn was created with the direct contact of an aluminum metal stamp heated in boiling water for 15 seconds. There was no implementation on or treatment of the control group (Group 1). Burn wounds were irrigated with saline solution (Saline group, Group 2), and silver sulphadiazine 1% (Silverdin®) cream (Group 3), Hypericum perforatum methanol extract-containing gel (Group 4), and a placebo gel (Group 5) were applied topically 4 times a day after the contact burn. Histopathological analyses of the burned area were made at 4, 8, and 24 hours.

Results: The topical use of Hypericum perforatum methanol extract-containing gel in the experimental contact burns, histologically; resulted in the reduction of collagen discoloration, vascular damage and hair follicle and glandula sebaceous damage while preserving total number of hair follicles, number of vessels and epidermal thickness compared to Silver Sulphadiazine 1% (Silverdin®) cream treatment.

Conclusion: Positive effects of topical Hypericum perforatum gel were detected on experimental burns and its use might have beneficial effects on acute burn wounds.

Keywords

Hypericum perforatum,burns,injuries,wound healing.

References

Şengezer M, Selmanpakoğlu N, Duman H, Çetin C. Epidemiological analysis of burn injuries in Gülhane Military Medical Academy Burn Center. Türk Plast Cer Derg 1995;3(1):74-7.
Colasanti A, Kisslinger A, Liuzzi R, et al. Hypericin photosensitization of tumor and metastatic cell lines of human prostate. J Photochem Photobiol B 2000;54(2-3):103-7.
Tang J, Colacino J.M, Larsen S.H. Virucidal activity of hypericin against enveloped and non-enveloped DNA and RNA viruses. Antiviral Res 1990;13(6):313-25.
Reichling J, Weseler A, Saller R. A current review of the antimicrobial activity of Hypericum perforatum L. Pharmacopsychiatry 2001;34(1):126-9.
Bayramoglu G, Bayramoglu A, Engur S, Senturk H, Ozturk N, Colak S. The hepatoprotective effects of Hypericum perforatum L. on hepatic ischemia/reperfusion injury in rats. Cytotechnology 2014;66(3):443-8.
Otto M, Bach FW, Jensen TS, Sindrup SH. Health-related quality of life and its predictive role for analgesic effect in patients with painful polyneuropathy. Eur J Pain 2007;11(5):572-8.
Pabuccuoğlu A, Konyalioğlu S, Bas M, Meral GE. The in vitro effects of Hypericum species on human leukocyte myeloperoxidase activity. J Ethnopharmacol 2003;57(1):59-92.
Albert D, Zundorf I, Dingermann T, Muller WE, Steinhilber D, Werz O. Hyperforin is a dual inhibitor of cyclooxygenase-1 and 5-lipoxygenase. Biochem Pharmacol 2002;15(12):1767-75.

Tedeschi E, Menegazzi M, Margotto D, Suzuki H, Forstermann U, Kleinert H. Antiinflammatory actions of St. John's Wort: Inhibition of human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha (STAT-1alpha) activation. J Pharmacol Exp Ther 2003;307(1):254-61.
Miller AL. St. John's Wort (Hypericum perforatum) clinical effects on depression and other conditions. Altern Med Rev 1998;3(1):18-26.
Rupal J, Kaushal J, Setty C, Mallikarjuna SC, Dipti P. Preparation and evaluation of topical gel of valdecoxib. Int J Pharmac Sci Drug Res 2010;2(1):51-4.
Singer AJ, Berruti L, Thode HC Jr, McClain SA. Standardized burn model using a multiparametric histologic analysis of burn depth. Acad Emerg Med 2000;7(1):1-6.
Li HL, Chen LP, Hu YH, et al. Crocodile oil enhances cutaneous burn wound healing and reduces scar formation in rats. Acad Emerg Med 2012;19(3):265-73.
Demling RH. Burns and other thermal injuries. In: Lawrence W, Lang GM (eds). Current Surgical Diagnosis and Treatment. New York; Medical Books/McGraw-Hill; 2002:267-81.
Taddonio TE, Thomson PD, Smith DJ, Prasad JK. A survey of wound monitoring and topical antimicrobial therapy practices in the treatment of burn injury. J Burn Care Rehabil 1990;11(5):423-7.
Lee AR, Moon HK. Effect of topically applied silver sulfadiazine on fibroblast cell proliferation and biomechanical properties of the wound. Arch Pharm Res 2003;26(10):855-60.
Stern HS. Silver sulphadiazine and the healing of partial thickness burns: A prospective clinical trial. Br J Plast Surg 1989;42(5):581-5.
Akdemir O, Hede Y, Zhang F, Lineaweaver WC, Arslan Z, Songur E. Effects of taurine on reperfusion injury. J Plast Reconstr Aesthet Surg 2011;64(7):921-28.
Burn incidence and treatment in the United States fact sheet, American Burn Association. Available at http://www.ameriburn.org. 2011.
Meyerholz DK, Piester TL, Sokolich JC, Zamba GK, Light TD. Morphological parameters for assessment of burn severity in an acute burn injury rat model. Int J Exp Pathol 2009;90(1):26-33.
Lavagna SM, Secci D, Chimenti P, Bonsignore L, Ottaviani A, Bizzarri B. Efficacy of Hypericum and Calendula oils in the epithelial reconstruction of surgical wounds in childbirth with caesarean section. II Farmaco 2001;56(5-7):451-3.

Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Derya Cabbaroğlu
0000-0002-2165-6936
Türkiye

Meltem Songür Kodik ^*
0000-0003-4565-3374
Türkiye

Yiğit Uyanıkgil
0000-0002-4016-0522
Türkiye

Emel Öykü Çetin Uyanıkgil
0000-0001-8822-9130
Türkiye

Fatih Karabey
0000-0003-0305-6192
Türkiye

Selahattin Kıyan
0000-0001-8431-7387
Türkiye

Publication Date

June 28, 2019

Submission Date

March 8, 2018

Acceptance Date

May 30, 2018

Published in Issue

Year 1970 Volume: 58 Number: 2

DOI

https://doi.org/10.19161/etd.512502

IZ

https://izlik.org/JA52AU48AB

Cite

RIS / Bibtex

Vancouver

1.Derya Cabbaroğlu, Meltem Songür Kodik, Yiğit Uyanıkgil, Emel Öykü Çetin Uyanıkgil, Fatih Karabey, Selahattin Kıyan. Treatment of contact burn injury with hypericum perforatum: An experimental study. EJM. 2019 Jun. 1;58(2):154-60. doi:10.19161/etd.512502

Cited By

The Effect of Ceruloplasmin Against Ischemia-Reperfusion Injury in Epigastric Island Flap in Rats

Journal of Surgical Research

https://doi.org/10.1016/j.jss.2021.05.045

The Effect of Botulinum Toxin on Flap Viability of the Posterior Thigh Perforator Flap in Rats

Journal of Surgical Research

https://doi.org/10.1016/j.jss.2020.12.025

Preventive effect of trimetazidine against ischemia-reperfusion injury in rat epigastric island flaps: an experimental study

European Journal of Plastic Surgery

https://doi.org/10.1007/s00238-020-01757-2

The potential role of Hypericum perforatum in wound healing: A literature review on the phytochemicals, pharmacological approaches, and mechanistic perspectives

Phytotherapy Research

https://doi.org/10.1002/ptr.8204

Polyphenol and Flavonoid Content and Antioxidant Activity of Hypericum perforatum L. (St. John’s Wort) Extracts for Potential Pharmaceutical and Cosmetic Applications

Applied Sciences

https://doi.org/10.3390/app15052590

Investıgatıon of the In vıtro and In vıvo Effect of A Mıxture Of Ficus carica L. and Hippophae rhamnoides L. on Experımentally Induced Burns in Rats

Burns

https://doi.org/10.1016/j.burns.2026.107921

Treatment of contact burn injury with hypericum perforatum: An experimental study

Treatment of contact burn injury with hypericum perforatum: An experimental study

Abstract

Keywords

Temas tipi yanıklarda Hypericum perforatum (sarı kantaron) ile tedavi: Deneysel bir çalışma

Öz

Anahtar Kelimeler

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

The Effect of Ceruloplasmin Against Ischemia-Reperfusion Injury in Epigastric Island Flap in Rats

The Effect of Botulinum Toxin on Flap Viability of the Posterior Thigh Perforator Flap in Rats

Preventive effect of trimetazidine against ischemia-reperfusion injury in rat epigastric island flaps: an experimental study

The potential role of Hypericum perforatum in wound healing: A literature review on the phytochemicals, pharmacological approaches, and mechanistic perspectives

Polyphenol and Flavonoid Content and Antioxidant Activity of Hypericum perforatum L. (St. John’s Wort) Extracts for Potential Pharmaceutical and Cosmetic Applications

Investıgatıon of the In vıtro and In vıvo Effect of A Mıxture Of Ficus carica L. and Hippophae rhamnoides L. on Experımentally Induced Burns in Rats