Mikroalbüminürisi olan ve olmayan tip 2 diyabetik hastalarda serum asimetrik dimetil arjinin, fetuin-A ve ankle-brakial indeks değerlerinin değerlendirilmesi

Aslı Kılavuz; Bakiye Göker; Sumru Savaş; Çığır Biray Avcı; Fulden Saraç; Cumhur Gündüz

doi:10.19161/etd.623697

EN TR

The evaluation of serum asymmetric dimethyl arginine, fetuin-A and ankle-brachial index values in type 2 diabetic patients with and without microalbuminuria

Abstract

Aim: We aimed to compare atherosclerosis markers in patients with type 2 diabetes mellitus with and without microalbuminuria.

Material and Methods: Eighty type 2 diabetes mellitus patients with and without microalbuminuria aged between 40-60 years were enrolled in this study. Serum levels of asymmetric dimethylarginine, fetuin-A and laboratory parameters such as lipid profile and A1c were evaluated. Ankle-brachial indexes were measured.

Results: No statistically significant correlation was found between microalbuminuria and total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, A1c, plasma fasting glucose, body mass index, ankle-brachial index. Patients with microalbuminuria had significantly lower serum fetuin-A levels in comparison with subjects of non-microalbuminuria (p=0.008).

However, a significant negative correlation was achieved between fetuin-A levels and microalbuminuria. We found that lower fetuin-A levels were associated with peripheric arterial disease, defined as ankle-brachial index ≤ 0.9 (p=0.001). There was a statistically significant correlation between microalbuminuria and serum asymmetric dimethylarginine levels. Patients with microalbuminuria had significantly higher serum asymmetric dimethylarginine levels in comparison with subjects with non-microalbuminuria (p=0.013).

Conclusion: Based on our results, it can be suggested that serum asymmetric dimethyl arginine is superior to fetuin-A in patients with type 2 diabetes mellitus and microalbuminuria for atherosclerotic process.

Keywords

Diabetes mellitus type 2,serum asymmetric dimethylarginine,fetuin A,ankle brachial index,microalbuminuria.

Mikroalbüminürisi olan ve olmayan tip 2 diyabetik hastalarda serum asimetrik dimetil arjinin, fetuin-A ve ankle-brakial indeks değerlerinin değerlendirilmesi

Öz

Amaç: Çalışmamızda mikroalbüminürisi olan ve olmayan tip 2 diabetes mellituslu hastalarda ateroskleroz belirteçlerini karşılaştırmayı amaçladık.

Gereç ve Yöntem: Bu çalışmaya 40-60 yaşları arasında, tip 2 diyabetli mikroalbüminürik ve mikroalbuminürisi olmayan 80 hasta dahil edildi. Hastaların serum asimetrik dimetil arjinin, fetuin-A düzeyleri, lipit profili ile açlık ve tokluk glukoz, A1c gibi laboratuvar parametreleri değerlendirildi. Ankle-brakiyal indeks (ABİ) ölçümleri yapıldı.

Bulgular: Mikroalbüminüri ile total kolesterol, trigliserid, LDL kolesterol, HDL kolesterol, A1c, plazma açlık glukozu, vücut kitle indeksi, ankle-brakiyal indeksi arasında istatistiksel olarak anlamlı bir ilişki bulunmadı. mikroalbüminürisi olan hastalar mikroalbüminürisi olmayan hastalara göre anlamlı olarak daha düşük serum fetuin-A düzeylerine sahipti (p = 0,008). Ancak, fetuin-A düzeyleri ve mikroalbüminüri arasında anlamlı negatif korelasyon elde edildi. Düşük fetuin-A düzeylerinin, ABİ ≤ 0,9 olarak tanımlanan periferik arter hastalığı ile ilişkili olduğu belirlendi (p = 0,001). Mikroalbüminüri ve serum asimetrik dimetil arjinin düzeyleri arasında istatistiksel olarak anlamlı ilişki saptandı. Mikroalbüminürisi olan hastaların, olmayanlara göre anlamlı olarak daha yüksek serum asimetrik dimetil arjinin düzeylerine sahip olduğu belirlendi (p = 0,013).

Sonuç: Çalışmamızın sonuçlarına göre, aterosklerotik süreçte tip 2 diabetes mellituslu mikroalbüminürisi olan hastalarda serum asimetrik dimetil arjininin fetuin-A'ya üstün olduğu ileri sürülebilir.

Anahtar Kelimeler

diabetes mellitus tip 2,serum asimetrik dimetil arjinin,fetuin A,ankle brakiyal indeks,mikroalbüminüri.

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Aslı Kılavuz ^*
0000-0002-0474-9911
Türkiye

Bakiye Göker
0000-0002-5714-7455
Türkiye

Sumru Savaş
0000-0003-4836-3786
Türkiye

Çığır Biray Avcı
0000-0002-2748-3124
Türkiye

Fulden Saraç
0000-0001-9281-2492
Türkiye

Cumhur Gündüz
0000-0002-6593-3237
Türkiye

Publication Date

December 30, 2019

Submission Date

November 9, 2018

Acceptance Date

January 14, 2019

Published in Issue

Year 2019 Volume: 58 Number: 4

DOI

https://doi.org/10.19161/etd.623697

IZ

https://izlik.org/JA34WY26MA

Cite

RIS / Bibtex

Vancouver

1.Aslı Kılavuz, Bakiye Göker, Sumru Savaş, Çığır Biray Avcı, Fulden Saraç, Cumhur Gündüz. Mikroalbüminürisi olan ve olmayan tip 2 diyabetik hastalarda serum asimetrik dimetil arjinin, fetuin-A ve ankle-brakial indeks değerlerinin değerlendirilmesi. EJM. 2019 Dec. 1;58(4):397-405. doi:10.19161/etd.623697