Diagnostik histeroskopi ve endometrial biyopsi ile embriyo transferi arası geçen süre gebelik sonuçları üzerine etkili midir?

Gülnaz Şahin; Ferruh Acet; Ege Nazan Tavmergen Göker; Erol Tavmergen

doi:10.19161/etd.888693

TR EN

Diagnostik histeroskopi ve endometrial biyopsi ile embriyo transferi arası geçen süre gebelik sonuçları üzerine etkili midir?

Öz

Amaç: In vitro fertilizasyon öncesi diagnostik histeroskopi ve endometrial hasar oluşturmanın etkinliği birçok çalışmada araştırılmıştır ve sonuçlar tartışmalıdır. Prosedürler arası optimal zaman aralığı ve optimal endometrial hasar oluşturma tekniği de net olarak tanımlanmamıştır. Bu çalışmanın amacı histeroskopi/endometrial biyopsi ile embriyo transferi arası zaman aralığının reprodüktif sonuçlar üzerine etkisini araştırmaktır. Gereç ve Yöntem: 2016-2018 yılları arasında, in vitro fertilizasyon siklusu öncesinde diagnostik histeroskopiyle birlikte endometrial biyopsi yapılan olgular retrospektif olarak analiz edildi. Hastalar prosedürler arası süreye göre beş gruba ayrıldı. Grupların reprodüktif sonuçları olarak klinik gebelik, gebelik kaybı ve canlı doğum oranları analiz edildi. Bulgular: Toplamda 252 hasta analize alındı, %49,2’si tekrarlayan implantasyon başarısızlığı olan olguları içeriyordu. Embriyo transfer siklusu olguların %29’unda histeroskopi/endometrial biyopsi prosedüründen 1 ay sonra, %32’sinde 2 ay sonra, %17,5’unda 3-4 ay sonra, %12’sinde 5-6 ay sonra ve %9,5’unda 6 aydan daha geç sürede uygulandı. Grupların temel karakteristikleri farklılık göstermiyordu. Grupların klinik gebelik (%34,2, %35,8, %31,8, %40 ve %37,5), gebelik kaybı (%8,2, %8,6, %9,1, %13,3 ve %8,3) ve canlı doğum oranları (%26, %27,2, %22,7, %26,7 ve %29,2) benzer olarak saptandı. Sonuç: Diagnostik histeroskopi/endometrial biyopsi ile embriyo transfer uygulaması arası geçen süre açısından reprodüktif sonuçlarda bir farklılık bulunmamaktadır. IVF-embriyo transferini ertesi menstrüel siklusta veya daha geç yapmak sonuçları etkilemeyebilir.

Anahtar Kelimeler

Does the time interval between diagnostic hysteroscopy with endometrial biopsy and embryo transfer affect pregnancy outcome?

Abstract

Aim: The effectiveness of diagnostic hysteroscopy and endometrial injury prior to the in vitro fertilization cycle has been examined in several studies with conflicting results. The optimal time interval for the procedures and the technique for endometrial injury have not described yet. The aim of this study is to investigate the effect of the time interval between hysteroscopy/endometrial biopsy procedure and embryo transfer on reproductive outcomes. Materials and Methods: Patients who underwent diagnostic H/S and endometrial biopsy procedure prior to the in vitro fertilization cycle, between 2016-2018 years, were retrospectively analyzed. Patients were divided into 5 groups according to the time interval between the procedures. Reproductive outcomes as clinical pregnancy rates, pregnancy loss rates, and live birth rates of the groups were analyzed. Results: A total of 252 patients were included to the analysis and 49.2% consisted of patients with repeated implantation failure. Totally 29% of the embryo transfer cycle was performed after one 1 month, 32% after 2 months, 17.5% after 3-4 months, 12% after 5-6 months and 9.5% after more than 6 months of the hysteroscopy/endometrial biopsy procedure. The baseline characteristics were not different between the groups. The clinical pregnancy (34.2%, 35.8%, 31.8%, 40% and 37.5%, respectively), pregnancy loss rate (%8.2, %8.6, %9.1, %13.3 ve %8.3) and live birth rates (26%, 27.2%, 22.7%, 26.7% and 29.2%, respectively) were similar of the groups. Conclusion: There is no significant difference in reproductive outcomes according to the time interval between diagnostic hysteroscopy/endometrial biopsy and embryo transfer procedures. Performing IVF-embryo transfer in the next menstrual cycle or later may not affect the outcomes.

Keywords

References

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Gülnaz Şahin ^*
0000-0002-5520-9229
Türkiye

Ferruh Acet
0000-0003-0628-0368
Türkiye

Ege Nazan Tavmergen Göker
0000-0003-3196-1624
Türkiye

Erol Tavmergen
0000-0002-2096-0637
Türkiye

Publication Date

March 31, 2021

Submission Date

August 7, 2020

Acceptance Date

December 1, 2020

Published in Issue

Year 2021 Volume: 60 Number: 1

DOI

https://doi.org/10.19161/etd.888693

IZ

https://izlik.org/JA55EL47LK

Cite

RIS / Bibtex

Vancouver

1.Gülnaz Şahin, Ferruh Acet, Ege Nazan Tavmergen Göker, Erol Tavmergen. Diagnostik histeroskopi ve endometrial biyopsi ile embriyo transferi arası geçen süre gebelik sonuçları üzerine etkili midir? EJM. 2021 Mar. 1;60(1):51-7. doi:10.19161/etd.888693