Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter

Hakan Bölükbaşı; Serhan Yılmaz

doi:10.19161/etd.888863

EN TR

Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter

Abstract

Aim: The aim of this study is to reveal the value of preoperative neutrophil lymphocyte ratio in differential diagnosis between papillary thyroid carcinoma, papillary thyroid microcarcinoma and benign multinodular goiter. Materials and methods: Patients with papillary thyroid carcinoma, papillary thyroid microcarcinoma, and multinodular goiter whose histopathological diagnosis was confirmed by postoperative pathology reports were included in the study. Results: The TSH levels were statistically significantly different among the groups (p < 0.001). The intergroup comparison revealed that the TSH levels were significantly lower in the multinodular goiter group compared to the papillary thyroid carcinoma and papillary thyroid microcarcinoma groups (p < 0.001, p0.001). The mean neutrophil count was 4.98 ± 1.19 in the papillary thyroid carcinoma group, 4.68 ± 1.33 in the papillary thyroid microcarcinoma group, and 4.59 ± 1.40 in the multinodular goiter group. The neutrophil counts of the groups were found to be significantly different (p = 0.013). The papillary thyroid carcinoma group had a significantly higher neutrophil count than the multinodular goiter group. The mean Neutrophil lymphocyte ratio value was 2.20 ± 0.71 in the papillary thyroid carcinoma group and 2.02 ± 0.92 in the multinodular goiter group. Neutrophil lymphocyte ratio values were significantly higher in the the papillary thyroid carcinoma group (p = 0.006). Conclucion: We believe that increased neutrophil lymphocyte ratio may be an indicator of underlying malignant disease in patients with thyroid nodules in the preoperative period.

Keywords

Nötrofil lenfosit oranı: Papiller tiroit kanserini multinodüler guatrdan gerçekten ayırt eder mi?

Abstract

Amaç: Bu çalışmanın amacı, preoperatif nötrofil lenfosit oranının papiller tiroit karsinomu, papiller tiroit mikrokarsinomu ve benign multinodüler guatr arasında ayırıcı tanıdaki değerini ortaya koymaktır. Metod: Çalışmaya, total tiroidektomi uygulanan ve histopatolojik tanıları postoperatif patoloji raporları ile doğrulanan papiller tiroit karsinomu, papiller tiroit mikrokarsinomu ve multinodüler guatr hastaları dahil edildi. Bulgular: Ortalama TSH düzeyi papiller tiroit karsinomu grubunda 1.85 ± 1.18 mIU / L, papiller tiroit mikrokarsinomu grubunda 1.78 ± 1.04 mIU / L ve multinodüler guatr grubunda 1.15 ± 0.91 mIU / L idi. TSH düzeyleri gruplar arasında istatistiksel olarak anlamlı farklıydı (p <0,001). Gruplar arası karşılaştırma, multinodüler guatr grubunda TSH seviyelerinin papiller tiroit karsinomu ve papiller tiroit mikrokarsinomu gruplarına kıyasla önemli ölçüde daha düşük olduğunu ortaya çıkardı (p <0.001, p0.001). Ortalama nötrofil sayısı papiller tiroit karsinomu grubunda 4,98 ± 1,19, papiller tiroit mikrokarsinomu grubunda 4,68 ± 1,33 ve multinodüler guatr grubunda 4,59 ± 1,40 idi. Grupların nötrofil sayıları anlamlı olarak farklı bulundu (p = 0,013). Papiller tiroit karsinomu grubu, multinodüler guatr grubuna göre önemli ölçüde daha yüksek nötrofil sayısına sahipti Ortalama nötrofil lenfosit oranı, papiller tiroit karsinomu grubunda 2.20 ± 0.71 ve multinodüler guatr grubunda 2.02 ± 0.92 idi. Nötrofil lenfosit oranı papiller tiroit karsinomu grubunda anlamlı olarak yüksekti (p = 0,006). Sonuç: Ameliyat öncesi dönemde tiroit nodülü olan hastalarda nötrofil lenfosit oranı artışının altta yatan kötü huylu hastalığın bir göstergesi olabileceğine inanıyoruz.

Keywords

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Hakan Bölükbaşı ^*
0000-0002-4904-9302
Türkiye

Serhan Yılmaz
0000-0002-5612-5932
Türkiye

Publication Date

March 31, 2021

Submission Date

October 20, 2020

Acceptance Date

December 16, 2020

Published in Issue

Year 2021 Volume: 60 Number: 1

DOI

https://doi.org/10.19161/etd.888863

IZ

https://izlik.org/JA24TY22HY

Cite

RIS / Bibtex

APA

Bölükbaşı, H., & Yılmaz, S. (2021). Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter. Ege Tıp Dergisi, 60(1), 63-69. https://doi.org/10.19161/etd.888863

AMA

1.Bölükbaşı H, Yılmaz S. Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter. EJM. 2021;60(1):63-69. doi:10.19161/etd.888863

Chicago

Bölükbaşı, Hakan, and Serhan Yılmaz. 2021. “Neutrophil to Iymphocyte Ratio: Does It Really Differentiate Between Papillary Thyroid Carcinomas and Multinodular Goiter”. Ege Tıp Dergisi 60 (1): 63-69. https://doi.org/10.19161/etd.888863.

EndNote

Bölükbaşı H, Yılmaz S (March 1, 2021) Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter. Ege Tıp Dergisi 60 1 63–69.

IEEE

[1]H. Bölükbaşı and S. Yılmaz, “Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter”, EJM, vol. 60, no. 1, pp. 63–69, Mar. 2021, doi: 10.19161/etd.888863.

ISNAD

Bölükbaşı, Hakan - Yılmaz, Serhan. “Neutrophil to Iymphocyte Ratio: Does It Really Differentiate Between Papillary Thyroid Carcinomas and Multinodular Goiter”. Ege Tıp Dergisi 60/1 (March 1, 2021): 63-69. https://doi.org/10.19161/etd.888863.

JAMA

1.Bölükbaşı H, Yılmaz S. Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter. EJM. 2021;60:63–69.

MLA

Bölükbaşı, Hakan, and Serhan Yılmaz. “Neutrophil to Iymphocyte Ratio: Does It Really Differentiate Between Papillary Thyroid Carcinomas and Multinodular Goiter”. Ege Tıp Dergisi, vol. 60, no. 1, Mar. 2021, pp. 63-69, doi:10.19161/etd.888863.

Vancouver

1.Hakan Bölükbaşı, Serhan Yılmaz. Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter. EJM. 2021 Mar. 1;60(1):63-9. doi:10.19161/etd.888863

Cited By

Diagnostic accuracy of neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in differentiating thyroid tumors: A systematic review and meta-analysis

PLOS One

https://doi.org/10.1371/journal.pone.0322382