Ege Ünı̇ versı̇tesı̇ hastanesı̇ veri tabanındaki özofagus kanserlerinin epidemiyolojisi ve sağkalım özellikleri

Nalan Gülşen Ünal; Halit Batuhan Demir; Murat Sezak; Serdar Özkök; Burçak Karaca; Bülent Karabulut; Burcu Çakar; Ayşe Caner; Ahmet Ömer Özütemiz; Sinan Ersin; Serhat Bor; Ahmet Aydın; Nevin Oruç; Rukiye Vardar; Fatih Tekin; İlker Turan; Gülin Kavakalan; Ayfer Haydaroğlu

doi:10.19161/etd.815112

TR EN

Ege Ünı̇ versı̇tesı̇ hastanesı̇ veri tabanındaki özofagus kanserlerinin epidemiyolojisi ve sağkalım özellikleri

Öz

Amaç: Bu çalışmada özofagus kanserlerinin (ÖK) epidemiyolojik ve genel sağkalım (GSK) özelliklerinin araştırılması amaçlanmıştır.

Gereç Yöntem: Ege Üniversitesi Kanserle Savaş Uygulama ve Araştırma Merkezinin 1992-2017 yılları arasındaki verileri retrospektif olarak taranmıştır. CANREG-4 bilgisayar programına kayıtlı kanser verileri, Dünya Sağlık Örgütü ve Surveillance, Epidemiology, and End Results sisteminde gruplanmış ve analizleri yapılmıştır. İstatistik analizlerde ki-kare testi, General Linear Model ve Kaplan Meier sağkalım analizleri uygulanmıştır.

Bulgular: Toplam 117.139 kanserden 19.542’u gastrointestinal sistem (GİS) kanserleridir. GİS kanserlerinin 1.009’u (%5,2) ÖK olup, GİS kanserleri içinde 6. sıklıktadır. ÖK’de 25 yılda doğrusal artış izlenmemiştir. Medyan yaş 60 (15-90) yıldır. Olguların 573’ü (%56,8) erkektir. ÖK, erkeklerde en sık 60- 69 yaşlarda (%31), kadınlarda 50-59 yaşlarda (%25,2) görülmektedir. En sık yerleşim torasik özofagustur (%79) ve yerleşim yeri açısından cinsiyetler arasında fark saptanmamıştır (p=0,33). Skuamöz hücreli karsinom (SHK) en sık rastlanan histolojik tiptir (%64,2). Servikal ve torasik özofagusda SHK, abdominal özofagusta adenokarsinom daha fazladır. Vakaların yaklaşık yarısı tanıyı lokal ileri evrede almıştır. Medyan sağkalım 12 aydır. Bir, 5 ve 10-yıllık GSK oranları, sırasıyla %50,1, %17,7 ve %12’dir. Erkeklerde 5-yıllık GSK oranı %11,2 ve kadınlarda %25,8’dir, cinsiyetler arası fark anlamlıdır (p<0,0001). SHK’da 5-yıllık GSK oranı %20, adenokanserlerde %11,5 saptanmıştır. Evrelere göre 5- yıllık GSK oranı; lokalize evrede %35,1, lokal ileri evrede %15,1 ve metastatik evrede %7,8 saptanmıştır.

Sonuç: ÖK, daha çok erkeklerde, torasik segmentte (orta özofagus) ve SHK histolojisinde saptanmıştır. Cinsiyet ve evre prognozda önemlidir.

Anahtar Kelimeler

Epidemiology and survival characteristics of patients with esophageal cancer in Ege Unıversity database

Abstract

Aim: The study aimed to investigate epidemiologic and overall survival (OS) characteristics of esophageal cancers (EC).

Materials and Methods: Data of Ege University Cancer Control and Research Center were screened between 1992-2017 retrospectively. Data recorded in the computer program CAN REG-4 were grouped and analyzed in the World Health Organisation and Surveillance, Epidemiology, and End Results systems. Chi-square, Kaplan Meier, and General Linear Model tests were used for statistical analysis.

Results: Of the total 117,139 cancers, 19,542 are gastrointestinal system (GIS) cancers. 1,009 (5.2%) of GIS cancers are EC and are 6th. There has not been any statistically significant increase in EC during the 25 years. The median age was 60 (15-90) years. A total of 573 (56.8%) of patients were male. EC was most commonly seen in men aged 60-69 (31%), in women aged 50-59 (25.2%) years. The most common localization was thoracic esophagus (79%). There wasn’t any statistically significant difference between gender according to localization (p=0.33). Squamous cell carcinoma (SCC) was the most common histological type (64.2%). SCC was more common in cervical and thoracic, adenocarcinoma was more common in abdominal esophagus. Half of the patients were diagnosed at a locally advanced stage. Median survival was 12 months. The 1-, 5-, and 10-year OS rates were 50.1%, 17.7%, and 12% respectively. The 5-year OS was 11.2% for men and 25.8% for women, the difference was statistically significant (p<0.0001). The 5-year OS of SCC was 20% and 11.5% in adenocarcinoma. The 5-year survival was 35.1% in local, 15.1% in locally advanced and 7.8% in metastatic stages, respectively.

Conclusion: EC was more common in men; the most common localization was thoracic segment. SCC was the most common histological type. Gender and stages are the most important parameters in prognosis.

Keywords

References

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Nalan Gülşen Ünal ^*
0000-0001-8870-2450
Türkiye

Halit Batuhan Demir
0000-0002-2746-7941
Türkiye

Murat Sezak
0000-0002-0457-4832
Türkiye

Serdar Özkök
0000-0001-6546-5368
Türkiye

Burçak Karaca
0000-0003-2638-1625
Türkiye

Bülent Karabulut
0000-0002-1949-8334
Türkiye

Burcu Çakar
0000-0003-3790-791X
Türkiye

Ayşe Caner
0000-0003-3058-9971
Türkiye

Ahmet Ömer Özütemiz
0000-0002-6960-4043
Türkiye

Sinan Ersin
0000-0003-4263-1727
Türkiye

Serhat Bor
0000-0001-5766-9598
Türkiye

Ahmet Aydın
0000-0001-8258-828X
Türkiye

Nevin Oruç
0000-0002-3057-6452
Türkiye

Rukiye Vardar
0000-0001-6161-3300
Türkiye

Fatih Tekin
Türkiye

İlker Turan
0000-0001-8998-1965
Türkiye

Gülin Kavakalan
0000-0003-4131-1414
Türkiye

Ayfer Haydaroğlu
0000-0001-5709-0981
Türkiye

Publication Date

October 26, 2020

Submission Date

August 28, 2020

Acceptance Date

October 5, 2020

Published in Issue

Year 2020

DOI

https://doi.org/10.19161/etd.815112

IZ

https://izlik.org/JA97FA97YF

Cite

RIS / Bibtex

Vancouver

1.Nalan Gülşen Ünal, Halit Batuhan Demir, Murat Sezak, Serdar Özkök, Burçak Karaca, Bülent Karabulut, Burcu Çakar, Ayşe Caner, Ahmet Ömer Özütemiz, Sinan Ersin, Serhat Bor, Ahmet Aydın, Nevin Oruç, Rukiye Vardar, Fatih Tekin, İlker Turan, Gülin Kavakalan, Ayfer Haydaroğlu. Ege Ünı̇ versı̇tesı̇ hastanesı̇ veri tabanındaki özofagus kanserlerinin epidemiyolojisi ve sağkalım özellikleri. EJM. 2020 Oct. 1;17-24. doi:10.19161/etd.815112