HISTOPATHOLOGIC FEATURES İN CHRONIC HEPATITIS C: A COMPARATIVE STUDY WITH CHRONIC HEPATITIS B

Volume: 39 Number: 1 March 1, 2000
  • Funda Yılmaz
  • Gül Yüce
  • Necmettin Özdemir
  • Galip Ersöz
  • Ulus S. Akarca
  • Yücel Batur
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HISTOPATHOLOGIC FEATURES İN CHRONIC HEPATITIS C: A COMPARATIVE STUDY WITH CHRONIC HEPATITIS B

Abstract

The aim of this study is to compare the histopathologic features observed in chronic hepatitis C (CHC) and chronic hepatitis B (CHB) in order to search for diagnostic clues. Liver biopsy materials, taken prior to İnterferon treatment from patients with clinico-pathological diagnoses of CHC (n:37) and CHB (n:23), betvveen 1989 and 1995 were included in the study. Histopathologic examination was performed for the detection of steatosis, acidophil bodies, bile duct lesions, activation of sinusoidal inflammatory cells, lymphoid aggregates and/or follicles in portal tracts, ground glass hepatocytes, nuclear polymorphism, sanded nuclei, Mallory body-like material, emperipolesis, pehpolesis, acidophilic change and large celi change (LCC) of hepatocytes. Most common features were; lymphoid aggregates and/or follicles in portal tracts (%86,48), pehpolesis (%70,27), steatosis (%51,35), acidophil bodies (%48,64), nuclear polymorphism (%43,24), bile duct lesions (%37,83), acidophilic change (%35,13), activation of sinusoidal inflammatory cells (%35,13), in CHC, and peripolesis (%91,30), nuclear polymorphism (%86,9), ground glass hepatocytes (%78,26), acidophilic change (%65,21), acidophil bodies (%65,21), sanded nuclei (%52,17) and emperipolesis (%52,17) in CHB. Occurence of lymphoid aggregates and/or follicles in portal tracts, bile duct lesions and activation of sinusoidal inflammatory cells in CHC and ground glass hepatocytes, nuclear polymorphism, emperipolesis, peripolesis, acidophilic change and LCC in CHB were found to be statistically significant (p

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Primary Language

Turkish

Subjects

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Journal Section

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Authors

Funda Yılmaz

Gül Yüce

Necmettin Özdemir

Galip Ersöz

Ulus S. Akarca

Yücel Batur

Publication Date

March 1, 2000

Submission Date

March 1, 2000

Acceptance Date

-

Published in Issue

Year 2000 Volume: 39 Number: 1

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https://izlik.org/JA68KS74PB

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1.Funda Yılmaz, Gül Yüce, Necmettin Özdemir, Galip Ersöz, Ulus S. Akarca, Yücel Batur. KRONİK C HEPATİTİNDE HİSTOPATOLOJİK ÖZELLİKLER: KRONİK B HEPATİTİ İLE KARŞILAŞTIRMALI BİR ÇALIŞMA. EJM [Internet]. 2000 Mar. 1;39(1):5-10. Available from: https://izlik.org/JA68KS74PB

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