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Glucose injury in diabetic rats' ovaries and effect of NF-kappa B way

Year 2013, Volume: 52 Issue: 1, 32 - 36, 01.03.2013

Abstract

Aim: To investigate glucose toxicity for ovarian damage severity and the effect of these by NF-kappa B way in rat models. Materials and Methods: An experimental diabetes mellitus model was created in seven rats. All seven rats, whose blood glucose levels were normal, were included in the control group. After eight weeks; bilateral oophorectomy was performed and the ovaries were researched histologically. The group characteristics were compared by one-way ANOVA and Mann Whitney U test. p values less than 0.05 were accepted as significant. Results: There was a significant increase of follicular degeneration, stromal degeneration, stromal fibrosis and NF-kappa B immune-expression in diabetic rats' ovary when compared to the control group of normal rats (p=0,0001). Conclusion: Our study shows that glucose toxicity occured severely in the ovaries and this injury originated in the NF-kappa B way in diabetes mellitus. Therefore, NF-kappa B inhibitors continue to be promising in preventing diabetic related tissue injury.

Diyabetik sıçan overlerindeki glikoz hasarı ve NF-kappa B yolunun etkisi

Year 2013, Volume: 52 Issue: 1, 32 - 36, 01.03.2013

Abstract

Amaç: Bu çalışmada, sıçan modellerinde glikoz toksisitesinin overdeki hasarlanma şiddeti ve bu hasarın NF-kappa B üzerinden etkilerinin olup olmadığının araştırılması amaçlandı. Gereç ve Yöntem: Yedi adet sıçanda deneysel olarak diyabetes mellitus modeli oluşturuldu. Yedi adet kan glikoz seviyesi normal olan sıçan kontrol grubu olarak alındı. Sekiz hafta sonra over dokuları çıkarılıp histolojik olarak incelendi. Grupların özellikleri, tek yönlü ANOVA ve Mann Whitney U testi ile karşılaştırıldı. p

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Details

Other ID JA93TJ22HN
Journal Section Research Articles
Authors

Pala H G

Erbaş O

Oltulu F

Pala E

Aktuğ H

Yavaşoğlu A

Publication Date March 1, 2013
Submission Date March 1, 2013
Published in Issue Year 2013Volume: 52 Issue: 1

Cite

Vancouver G PH, O E, F O, E P, H A, A Y. Diyabetik sıçan overlerindeki glikoz hasarı ve NF-kappa B yolunun etkisi. EJM. 2013;52(1):32-6.