The effect of adjuvant treatment modalities on survival outcomes in cytoreductive surgery performed patients with advanced stage uterine sarcomas

Volume: 52 Number: 4 December 1, 2013
  • Rtas İ E
  • Doğan A
  • Özdemir A
  • Solmaz U
  • Göklü R
  • İldırım Y
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The effect of adjuvant treatment modalities on survival outcomes in cytoreductive surgery performed patients with advanced stage uterine sarcomas

Abstract

Aim: To analyse the effect of adjuvant treatment modalities on survival outcomes in cytoreductive surgery (CRS) performed on patients diagnosed with advanced stage uterine sarcomas. Materials and Methods: Between the years of 1/1994–1/2009; among (n=122) patients with uterine sarcoma that were diagnosed and treated at our center, n=26 (21%) who had advanced (FIGO stage III and IV) disease were the subject of this retrospective study. The stage of the disease, tumor histology, presence of lymphadenectomy, optimality of cytoreductive surgery, adjuvant radiotherapy (RT) and chemotherapy (CT) applications, disease-free survival (DFS) and overall survival (OVS) rates were the main outcome measures. Data were presented by performing descriptive analyses, Kaplan-Meier and the log-rank test. Results: Histologically, cases consist of 9 (34.6%) leiomyosarcoma;3 (11.4%) endometrial stromal sarcoma and 14 (54%) carsinosarcoma. Systematic lymphadenectomy was performed in the forms only bilateral pelvic (n = 9); bilateral pelvic + para-aortic (n=17). Optimal cytoreduction was achieved in 23 (88%) of 26 patients. Only CT (n = 10) and CT + RT (n=16) were applied as adjuvant treatments. The mean survival of patient groups on which (CRS+ adjuvant CT)–(CRS+adjuvant CT+RT) were performed was determined as [12.6–42.3] months (p< 0.05) in terms of DFS and, [21.8–52.8] months (p

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Primary Language

Turkish

Subjects

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Journal Section

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Authors

Rtas İ E

Doğan A

Özdemir A

Solmaz U

Göklü R

İldırım Y

Publication Date

December 1, 2013

Submission Date

December 1, 2013

Acceptance Date

-

Published in Issue

Year 1970 Volume: 52 Number: 4

IZ

https://izlik.org/JA56BA97UJ

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1.Rtas İ E, Doğan A, Özdemir A, Solmaz U, Göklü R, İldırım Y. Sitoredüktif cerrahi yapılan ileri evre uterin sarkomlu hastalarda adjuvan tedavi modalitelerinin sağkalım sonuçları üzerine etkisi. EJM [Internet]. 2013 Dec. 1;52(4):179-84. Available from: https://izlik.org/JA56BA97UJ

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