Abstract
Yaşla
birlikte epigastrik şikâyetler daha yaygın görülmekte ve bu nedenle proton
pompası inhibitörlerine (PPİ) yaşlılarda daha sık başvurulmaktadır. PPİ
tedavisi, zararsız olduğu yönündeki algı nedeniyle uygunsuz doz ve sürede
kullanılmaktadır. Uzun süre PPI kullanımına bağlı ortaya çıkan sık yan etkiler;
enfeksiyonlar (Clostridium difficile
enteriti, mikroskobik kolit, toplum kaynaklı pnömoni), sindirim ve emilim
bozuklukları (vitamin B12, demir, kalsiyum eksiklikleri, hipofosfatemi,
hipomagnezemi), kemik kırıkları, akut interstisyel nefrit, demans, kronik
böbrek yetmezliğidir. Bu olguda kronik PPİ kullanımının nadir görülen yan
etkilerinden biri olan nöroendokrin tümör sunularak uygunsuz ilaç kullanımının
sonuçlarına dikkat çekilmek istenmiştir.
References
- Thompson W, Black C, Welch V, Farrell B, Bjerre LM, Tugwell P. Patient values and preferences surrounding proton pump inhibitor use: A scoping review. Patient 2018;11(1):17-28.
- Cavalcoli F, Zilli A, Conte D, Ciafardini C, Massironi S. Gastric neuroendocrine neoplasms and proton pump inhibitors: Fact or coincidence? Scand J Gastroenterol 2015;50(11):1397-403.
- Uygun A. Uzun süre proton pompa inhibitörleri (PPI) kullanılacaksa, hangi PPI tercih edilmelidir? Nelere dikkat edilmelidir? Güncel Gastroenterol 2013;17(1):46-58.
- O'Mahony D, O'Sullivan D, Byrne S, O'Connor MN, Ryan C, Gallagher P. STOPP/START criteria for potentially inappropriate prescribing in older people: Version 2. Age Ageing 2015;44(2):213-8.
- Lundell L, Vieth M, Gibson F, Nagy P, Kahrilas PJ. Systematic review: The effects of long-term proton pump inhibitor use on serum gastrin levels and gastric histology. Aliment Pharmacol Ther 2015;42(6):649-63.
- Nandy N, Hanson JA, Strickland RG, McCarthy DM. Solitary gastric carcinoid tumor associated with long-term use of omeprazole: A case report and review of the literature. Dig Dis Sci 2016;61(3):708-12.
- Chan EW, Lau WC, Leung WK, et al. Prevention of dabigatran-related gastrointestinal bleeding with gastroprotective agents: A population-based study. Gastroenterology 2015;149(3):586-95.
- Sherwood MW, Nessel CC, Hellkamp AS, et al. Gastrointestinal bleeding in patients with atrial fibrillation treated with rivaroxaban or warfarin: ROCKET AF trial. J Am Coll Cardiol 2015;66(21):2271-81.
- İnce AT, Tosun S. Gastroenteropankreatik nöroendokrin tümörler. Güncel Gastroenterol 2005;9(3):105-14.
Abstract
Abdominal
complaints are more common in elderly, therefore the use of proton pump
inhibitors (PPI) has increased in the aging population. PPI is prescribed
inappropriately, as PPIs have long been perceived relatively harmless. Advers
risks associated with chronic use of PPI; infections (Clostridium difficile
enteritis, microscopic colitis, community-acquired pneumonia), digestive and
absorption disorders (vitamin B12, iron, calcium deficiencies,
hypophosphatemia, hypomagnesemia), bone fractures, acute interstitial
nephritis, dementia, chronic renal disease. In this case, neuroendocrine tumor,
which is one of the rare side effects of chronic PPI use, is presented to
derive the attention of health professionals, to the impact of inappropriate
drug use.
References
- Thompson W, Black C, Welch V, Farrell B, Bjerre LM, Tugwell P. Patient values and preferences surrounding proton pump inhibitor use: A scoping review. Patient 2018;11(1):17-28.
- Cavalcoli F, Zilli A, Conte D, Ciafardini C, Massironi S. Gastric neuroendocrine neoplasms and proton pump inhibitors: Fact or coincidence? Scand J Gastroenterol 2015;50(11):1397-403.
- Uygun A. Uzun süre proton pompa inhibitörleri (PPI) kullanılacaksa, hangi PPI tercih edilmelidir? Nelere dikkat edilmelidir? Güncel Gastroenterol 2013;17(1):46-58.
- O'Mahony D, O'Sullivan D, Byrne S, O'Connor MN, Ryan C, Gallagher P. STOPP/START criteria for potentially inappropriate prescribing in older people: Version 2. Age Ageing 2015;44(2):213-8.
- Lundell L, Vieth M, Gibson F, Nagy P, Kahrilas PJ. Systematic review: The effects of long-term proton pump inhibitor use on serum gastrin levels and gastric histology. Aliment Pharmacol Ther 2015;42(6):649-63.
- Nandy N, Hanson JA, Strickland RG, McCarthy DM. Solitary gastric carcinoid tumor associated with long-term use of omeprazole: A case report and review of the literature. Dig Dis Sci 2016;61(3):708-12.
- Chan EW, Lau WC, Leung WK, et al. Prevention of dabigatran-related gastrointestinal bleeding with gastroprotective agents: A population-based study. Gastroenterology 2015;149(3):586-95.
- Sherwood MW, Nessel CC, Hellkamp AS, et al. Gastrointestinal bleeding in patients with atrial fibrillation treated with rivaroxaban or warfarin: ROCKET AF trial. J Am Coll Cardiol 2015;66(21):2271-81.
- İnce AT, Tosun S. Gastroenteropankreatik nöroendokrin tümörler. Güncel Gastroenterol 2005;9(3):105-14.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Case Reports |
| Authors | |
| Publication Date | December 3, 2018 |
| Submission Date | September 5, 2017 |
| Published in Issue | Year 2018Volume: 57 Issue: 4 |
