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Microbial colonization and antimicrobial susceptibility of the nose and external ear canal in hemodialysis patients

Year 2019, Volume 58, Issue 2, 126 - 130, 28.06.2019
https://doi.org/10.19161/etd.458846

Abstract

Aim: The effect of normal bacterial flora on the immune system is to make it more effective against harmful micro-organisms and to maintain it in readiness for a more rapid response. The purpose of this study was to determine the bacterial flora in the external ear canal and nasal cavities in hemodialysis patients, to compare this with the normal population and to show the microorganisms’ antibiotic susceptibilities.

Materials and Methods: Patients receiving hemodialysis therapy for at least 3 years were included in the study. A control group (n=62) was established consisting of patients with no immune-suppressive condition and presenting to hospital with non-ear symptoms. Swab specimens were taken from all subjects’ external ear canals and nasal cavities. Results of the cultures were recorded and antimicrobial susceptibility test was performed.

Results: The most commonly isolated micro-organisms in the study group were MRCoNS (41%), followed by MSCoNS (15.5%) and diphtheroids (9.8%). The micro-organism most commonly isolated from the nasal cavity in the study group was CoNS (52.7%), of which MRCoNS constituted 69.2%.

Conclusion: We think that infections that play a major role in mortality and morbidity in hemodialysis patients may originate from the external ear canal as much as the nasal cavity, for this reason it is important for micro-organisms colonizing these regions to be eliminated with appropriate treatment on the basis of antibiotic susceptibility tests. 

References

  • 1. Stroman DW, Roland PS, Dohar J, Burt W. Microbiology of normal external auditory canal. Laryngoscope 2001;111(11):2054-9.
  • Ucuncu H, Uslu H, Ozbek A, Aktan B, Sutbeyaz Y, Altas E. Comparison of the bacterial flora of the nasal vestibule and cavity in haemodialysis patients. Acta Otorhinolaryngol Ital 2009;29(5):251-4.
  • Celik G, Gülcan A, Dikici N, Gülcan E. Prevalence of nasal Staphylococcus aureus carriage in the patients undergoing hemodialysis and evaluation of risk factors and laboratory parameters. Ren Fail 2011;33(5):494-8.
  • Brook I. Microbiological studies of the bacterial flora of the external auditory canal in children. Acta Otolaryngol 1981;91(3-4):285-7.
  • Wright DN, Alexander JM. Effect of water on the bacterial flora of swimmer’s ears. Arch Otolaryngol 1974;99(1):15-8.
  • Salit IE, Miller B, Wigmore M, Smith JA. Bacterial flora of the external canal in diabetics and non-diabetics. Laryngoscope 1982;92(6Pt1):672-3.
  • European Committee on Antimicrobial Susceptibility Testing. Clinical Breakpoints tables of interpretation of MIC’s and zone diameters. Version 6.0, (Dec.31,2016). Available from: http//www.eucast.org
  • Ostfeld E, Rubinstein E, Gazit E, Smetana Z. Effect of systemic antibiotics on the microbial flora of the external ear canal in hospitalized children. Pediatrics 1977;60(3):364-6.
  • Hoen B, Kessler M, Hestin D, Mayeux D. Risk factors for bacterial infections in chronic haemodialysis adult patients: A multicentre prospective survey. Nephrol Dial Transplant 1995;10(3);377-81.
  • Alcelik A, Apuhan T, Kocoglu E, Eroglu M, Necati Hakyemez I, Duran A. Microbial colonization of the external auditory canal and nose in hemodialysis patients. Med Glas 2012;9(2):330-3.
  • Lai CF, Liao CH, Pai MF, et al. Nasal carriage of methicillin-resistant Staphylococcus aureus is associated with higher all-cause mortality in hemodialysis patients. Clin J Am Soc Nephrol 2011;6(1):167-74.
  • Zimakoff J, Bangsgaard Pedersen F, Bergen L, et al. Staphylococcus aureus carriage and infections among patients in four haemo- and peritoneal-dialysis centres in Denmark. The Danish Study Group of Peritonitis in Dialysis (DASPID). J Hosp Infect 1996;33(4):289-300.
  • Motamedifar M, Hassanzadeh P, Ghafari N. Relative frequency of Staphylococcal carriage and antibiotic sensitivity of isolated Staphylococci in hemodialysis patients in Shiraz, Iran. Med Princ Pract 2010;19(5):379-83.

Hemodiyaliz hastalarında dış kulak yolu ve nazal kavitede mikrobiyal kolonizasyon ve antimikrobiyal duyarlılık

Year 2019, Volume 58, Issue 2, 126 - 130, 28.06.2019
https://doi.org/10.19161/etd.458846

Abstract

Amaç: Normal bakteriyel floranın bağışıklık üzerindeki etkisi onu mikroorganizmaların zararlı etkilerine karşı daha etkili hale getirmek ve hızlı bir cevap oluşturacak şekilde hazır tutmaktır. Bu çalışmanın amacı hemodiyaliz hastalarında nazal kavite ve dış kulak yolundaki bakteriyel florayı tespit etmek, bunu normal populasyonla karşılaştırmak ve mikroorganizmaların antimikrobiyal duyarlılığını ortaya koymaktı.

Gereç ve Yöntem: Çalışmaya en az 3 yıldır hemodiyaliz alan hastalar dâhil edildi. Herhangi bir immunsupresyon durumu olmayan ve kulak hastalıkları dışı sebeplerle hastaneye başvuran hastalardan da kontrol grubu oluşturuldu (n=62). Tüm katılımcıların nazal kavite ve dış kulak yollarından kültür çubuğu ile kültür örnekleri alındı. Kültür sonuçları ile antimikrobiyal duyarlılık test sonuçları kaydedildi.

Bulgular: Çalışma grubunda dış kulak yolundan en çok izole edilen bakteri MRCoNS (%41) iken bunu MSCoNS (%15,5) ve Difteroidler (%9,8) izlemekteydi. Nazal kaviteden ise en sık izole edilen bakteri CoNS olup (%52,7) bunun %69,2’sini MRCoNS oluşturmaktaydı.

Sonuç: Hemodiyaliz hastalarında mortalite ve morbiditede önemli rol oynayan enfeksiyonların nazal kavite kadar dış kulak yolundan da kaynaklanabileceğini, bu nedenle antimikrobiyal duyarlılık testleri ile belirlenen uygun antibiyoterapi ile bu bölgedeki mikroorganizmaların da elimine edilmesinin önemli olduğunu düşünmekteyiz.

References

  • 1. Stroman DW, Roland PS, Dohar J, Burt W. Microbiology of normal external auditory canal. Laryngoscope 2001;111(11):2054-9.
  • Ucuncu H, Uslu H, Ozbek A, Aktan B, Sutbeyaz Y, Altas E. Comparison of the bacterial flora of the nasal vestibule and cavity in haemodialysis patients. Acta Otorhinolaryngol Ital 2009;29(5):251-4.
  • Celik G, Gülcan A, Dikici N, Gülcan E. Prevalence of nasal Staphylococcus aureus carriage in the patients undergoing hemodialysis and evaluation of risk factors and laboratory parameters. Ren Fail 2011;33(5):494-8.
  • Brook I. Microbiological studies of the bacterial flora of the external auditory canal in children. Acta Otolaryngol 1981;91(3-4):285-7.
  • Wright DN, Alexander JM. Effect of water on the bacterial flora of swimmer’s ears. Arch Otolaryngol 1974;99(1):15-8.
  • Salit IE, Miller B, Wigmore M, Smith JA. Bacterial flora of the external canal in diabetics and non-diabetics. Laryngoscope 1982;92(6Pt1):672-3.
  • European Committee on Antimicrobial Susceptibility Testing. Clinical Breakpoints tables of interpretation of MIC’s and zone diameters. Version 6.0, (Dec.31,2016). Available from: http//www.eucast.org
  • Ostfeld E, Rubinstein E, Gazit E, Smetana Z. Effect of systemic antibiotics on the microbial flora of the external ear canal in hospitalized children. Pediatrics 1977;60(3):364-6.
  • Hoen B, Kessler M, Hestin D, Mayeux D. Risk factors for bacterial infections in chronic haemodialysis adult patients: A multicentre prospective survey. Nephrol Dial Transplant 1995;10(3);377-81.
  • Alcelik A, Apuhan T, Kocoglu E, Eroglu M, Necati Hakyemez I, Duran A. Microbial colonization of the external auditory canal and nose in hemodialysis patients. Med Glas 2012;9(2):330-3.
  • Lai CF, Liao CH, Pai MF, et al. Nasal carriage of methicillin-resistant Staphylococcus aureus is associated with higher all-cause mortality in hemodialysis patients. Clin J Am Soc Nephrol 2011;6(1):167-74.
  • Zimakoff J, Bangsgaard Pedersen F, Bergen L, et al. Staphylococcus aureus carriage and infections among patients in four haemo- and peritoneal-dialysis centres in Denmark. The Danish Study Group of Peritonitis in Dialysis (DASPID). J Hosp Infect 1996;33(4):289-300.
  • Motamedifar M, Hassanzadeh P, Ghafari N. Relative frequency of Staphylococcal carriage and antibiotic sensitivity of isolated Staphylococci in hemodialysis patients in Shiraz, Iran. Med Princ Pract 2010;19(5):379-83.

Details

Primary Language English
Subjects Health Care Sciences and Services
Journal Section Research Articles
Authors

Korhan KILIÇ (Primary Author)
Atatürk University Faculty of Medicine, Department of Otorhinolaryngology, Erzurum
0000-0001-6048-034X
Türkiye


Eylül DERMAN This is me
Atatürk University Faculty of Medicine, Department of Medical Microbiology, Erzurum
0000-0002-4533-0308
Türkiye


Muhammed Sedat SAKAT This is me
Atatürk University Faculty of Medicine, Department of Otorhinolaryngology, Erzurum
0000-0001-9588-1725
Türkiye


Mustafa Sıtkı GÖZELER This is me
Atatürk University Faculty of Medicine, Department of Otorhinolaryngology, Erzurum
0000-0002-9716-9579
Türkiye


Hakan USLU This is me
Atatürk University Faculty of Medicine, Department of Medical Microbiology, Erzurum
0000-0003-1478-7441
Türkiye


Furkan ŞENGÖZ This is me
Atatürk University Faculty of Medicine, Department of Otorhinolaryngology, Erzurum
0000-0001-9109-2681
Türkiye

Publication Date June 28, 2019
Application Date January 5, 2018
Acceptance Date May 9, 2018
Published in Issue Year 2019, Volume 58, Issue 2

Cite

Bibtex @research article { etd458846, journal = {Ege Tıp Dergisi}, issn = {1016-9113}, eissn = {2147-6500}, address = {}, publisher = {Ege University}, year = {2019}, volume = {58}, pages = {126 - 130}, doi = {10.19161/etd.458846}, title = {Microbial colonization and antimicrobial susceptibility of the nose and external ear canal in hemodialysis patients}, key = {cite}, author = {Kılıç, Korhan and Derman, Eylül and Sakat, Muhammed Sedat and Gözeler, Mustafa Sıtkı and Uslu, Hakan and Şengöz, Furkan} }
APA Kılıç, K. , Derman, E. , Sakat, M. S. , Gözeler, M. S. , Uslu, H. & Şengöz, F. (2019). Microbial colonization and antimicrobial susceptibility of the nose and external ear canal in hemodialysis patients . Ege Tıp Dergisi , 58 (2) , 126-130 . DOI: 10.19161/etd.458846
MLA Kılıç, K. , Derman, E. , Sakat, M. S. , Gözeler, M. S. , Uslu, H. , Şengöz, F. "Microbial colonization and antimicrobial susceptibility of the nose and external ear canal in hemodialysis patients" . Ege Tıp Dergisi 58 (2019 ): 126-130 <http://egetipdergisi.com.tr/en/pub/issue/44438/458846>
Chicago Kılıç, K. , Derman, E. , Sakat, M. S. , Gözeler, M. S. , Uslu, H. , Şengöz, F. "Microbial colonization and antimicrobial susceptibility of the nose and external ear canal in hemodialysis patients". Ege Tıp Dergisi 58 (2019 ): 126-130
RIS TY - JOUR T1 - Microbial colonization and antimicrobial susceptibility of the nose and external ear canal in hemodialysis patients AU - Korhan Kılıç , Eylül Derman , Muhammed Sedat Sakat , Mustafa Sıtkı Gözeler , Hakan Uslu , Furkan Şengöz Y1 - 2019 PY - 2019 N1 - doi: 10.19161/etd.458846 DO - 10.19161/etd.458846 T2 - Ege Tıp Dergisi JF - Journal JO - JOR SP - 126 EP - 130 VL - 58 IS - 2 SN - 1016-9113-2147-6500 M3 - doi: 10.19161/etd.458846 UR - https://doi.org/10.19161/etd.458846 Y2 - 2018 ER -
EndNote %0 Ege Journal of Medicine Microbial colonization and antimicrobial susceptibility of the nose and external ear canal in hemodialysis patients %A Korhan Kılıç , Eylül Derman , Muhammed Sedat Sakat , Mustafa Sıtkı Gözeler , Hakan Uslu , Furkan Şengöz %T Microbial colonization and antimicrobial susceptibility of the nose and external ear canal in hemodialysis patients %D 2019 %J Ege Tıp Dergisi %P 1016-9113-2147-6500 %V 58 %N 2 %R doi: 10.19161/etd.458846 %U 10.19161/etd.458846
ISNAD Kılıç, Korhan , Derman, Eylül , Sakat, Muhammed Sedat , Gözeler, Mustafa Sıtkı , Uslu, Hakan , Şengöz, Furkan . "Microbial colonization and antimicrobial susceptibility of the nose and external ear canal in hemodialysis patients". Ege Tıp Dergisi 58 / 2 (June 2019): 126-130 . https://doi.org/10.19161/etd.458846
AMA Kılıç K. , Derman E. , Sakat M. S. , Gözeler M. S. , Uslu H. , Şengöz F. Microbial colonization and antimicrobial susceptibility of the nose and external ear canal in hemodialysis patients. EJM. 2019; 58(2): 126-130.
Vancouver Kılıç K. , Derman E. , Sakat M. S. , Gözeler M. S. , Uslu H. , Şengöz F. Microbial colonization and antimicrobial susceptibility of the nose and external ear canal in hemodialysis patients. Ege Tıp Dergisi. 2019; 58(2): 126-130.
IEEE K. Kılıç , E. Derman , M. S. Sakat , M. S. Gözeler , H. Uslu and F. Şengöz , "Microbial colonization and antimicrobial susceptibility of the nose and external ear canal in hemodialysis patients", Ege Tıp Dergisi, vol. 58, no. 2, pp. 126-130, Jun. 2019, doi:10.19161/etd.458846