Year 2019, Volume 58 , Issue 4, Pages 397 - 405 2019-12-30

Mikroalbüminürisi olan ve olmayan tip 2 diyabetik hastalarda serum asimetrik dimetil arjinin, fetuin-A ve ankle-brakial indeks değerlerinin değerlendirilmesi
The evaluation of serum asymmetric dimethyl arginine, fetuin-A and ankle-brachial index values in type 2 diabetic patients with and without microalbuminuria

Aslı KILAVUZ [1] , Bakiye GÖKER [2] , Sumru SAVAŞ [3] , Çığır BİRAY AVCI [4] , Fulden SARAÇ [5] , Cumhur GÜNDÜZ [6]


Amaç: Çalışmamızda mikroalbüminürisi olan ve olmayan tip 2 diabetes mellituslu hastalarda ateroskleroz belirteçlerini karşılaştırmayı amaçladık.

Gereç ve Yöntem: Bu çalışmaya 40-60 yaşları arasında, tip 2 diyabetli mikroalbüminürik ve mikroalbuminürisi olmayan 80 hasta dahil edildi. Hastaların serum asimetrik dimetil arjinin, fetuin-A düzeyleri, lipit profili ile açlık ve tokluk glukoz, A1c gibi laboratuvar parametreleri değerlendirildi. Ankle-brakiyal indeks (ABİ) ölçümleri yapıldı.

Bulgular: Mikroalbüminüri ile total kolesterol, trigliserid, LDL kolesterol, HDL kolesterol, A1c, plazma açlık glukozu, vücut kitle indeksi, ankle-brakiyal indeksi arasında istatistiksel olarak anlamlı bir ilişki bulunmadı. mikroalbüminürisi olan hastalar mikroalbüminürisi olmayan hastalara göre anlamlı olarak daha düşük serum fetuin-A düzeylerine sahipti (p = 0,008). Ancak, fetuin-A düzeyleri ve mikroalbüminüri arasında anlamlı negatif korelasyon elde edildi. Düşük fetuin-A düzeylerinin, ABİ ≤ 0,9 olarak tanımlanan periferik arter hastalığı ile ilişkili olduğu belirlendi (p = 0,001). Mikroalbüminüri ve serum asimetrik dimetil arjinin düzeyleri arasında istatistiksel olarak anlamlı ilişki saptandı. Mikroalbüminürisi olan hastaların, olmayanlara göre anlamlı olarak daha yüksek serum asimetrik dimetil arjinin düzeylerine sahip olduğu belirlendi (p = 0,013).

Sonuç: Çalışmamızın sonuçlarına göre, aterosklerotik süreçte tip 2 diabetes mellituslu mikroalbüminürisi olan hastalarda serum asimetrik dimetil arjininin fetuin-A'ya üstün olduğu ileri sürülebilir.

Aim: We aimed to compare atherosclerosis markers in patients with type 2 diabetes mellitus with and without microalbuminuria.

Material and Methods: Eighty type 2 diabetes mellitus patients with and without microalbuminuria aged between 40-60 years were enrolled in this study. Serum levels of asymmetric dimethylarginine, fetuin-A and laboratory parameters such as lipid profile and A1c were evaluated. Ankle-brachial indexes were measured.

Results: No statistically significant correlation was found between microalbuminuria and total cholesterol, triglyceride, LDL cholesterol, HDL cholesterol, A1c, plasma fasting glucose, body mass index, ankle-brachial index. Patients with microalbuminuria had significantly lower serum fetuin-A levels in comparison with subjects of non-microalbuminuria (p=0.008).

However, a significant negative correlation was achieved between fetuin-A levels and microalbuminuria. We found that lower fetuin-A levels were associated with peripheric arterial disease, defined as ankle-brachial index ≤ 0.9 (p=0.001). There was a statistically significant correlation between microalbuminuria and serum asymmetric dimethylarginine levels. Patients with microalbuminuria had significantly higher serum asymmetric dimethylarginine levels in comparison with subjects with non-microalbuminuria (p=0.013).

Conclusion: Based on our results, it can be suggested that serum asymmetric dimethyl arginine is superior to fetuin-A in patients with type 2 diabetes mellitus and microalbuminuria for atherosclerotic process.



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Primary Language tr
Subjects Health Care Sciences and Services
Journal Section Research Articles
Authors

Orcid: 0000-0002-0474-9911
Author: Aslı KILAVUZ (Primary Author)
Institution: Ege Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, İzmir
Country: Turkey


Orcid: 0000-0002-5714-7455
Author: Bakiye GÖKER
Institution: Ege Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, İzmir
Country: Turkey


Orcid: 0000-0003-4836-3786
Author: Sumru SAVAŞ
Institution: Ege Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, İzmir
Country: Turkey


Orcid: 0000-0002-2748-3124
Author: Çığır BİRAY AVCI
Institution: Ege Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, İzmir
Country: Turkey


Orcid: 0000-0001-9281-2492
Author: Fulden SARAÇ
Institution: Ege Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, İzmir
Country: Turkey


Orcid: 0000-0002-6593-3237
Author: Cumhur GÜNDÜZ
Institution: Ege Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, İzmir
Country: Turkey


Dates

Application Date : November 9, 2018
Acceptance Date : January 14, 2019
Publication Date : December 30, 2019

Bibtex @research article { etd623697, journal = {Ege Tıp Dergisi}, issn = {1016-9113}, eissn = {2147-6500}, address = {}, publisher = {Ege University}, year = {2019}, volume = {58}, pages = {397 - 405}, doi = {10.19161/etd.623697}, title = {Mikroalbüminürisi olan ve olmayan tip 2 diyabetik hastalarda serum asimetrik dimetil arjinin, fetuin-A ve ankle-brakial indeks değerlerinin değerlendirilmesi}, key = {cite}, author = {Kılavuz, Aslı and Göker, Bakiye and Savaş, Sumru and Biray Avcı, Çığır and Saraç, Fulden and Gündüz, Cumhur} }
APA Kılavuz, A , Göker, B , Savaş, S , Biray Avcı, Ç , Saraç, F , Gündüz, C . (2019). Mikroalbüminürisi olan ve olmayan tip 2 diyabetik hastalarda serum asimetrik dimetil arjinin, fetuin-A ve ankle-brakial indeks değerlerinin değerlendirilmesi . Ege Tıp Dergisi , 58 (4) , 397-405 . DOI: 10.19161/etd.623697
MLA Kılavuz, A , Göker, B , Savaş, S , Biray Avcı, Ç , Saraç, F , Gündüz, C . "Mikroalbüminürisi olan ve olmayan tip 2 diyabetik hastalarda serum asimetrik dimetil arjinin, fetuin-A ve ankle-brakial indeks değerlerinin değerlendirilmesi" . Ege Tıp Dergisi 58 (2019 ): 397-405 <http://egetipdergisi.com.tr/en/pub/issue/50673/623697>
Chicago Kılavuz, A , Göker, B , Savaş, S , Biray Avcı, Ç , Saraç, F , Gündüz, C . "Mikroalbüminürisi olan ve olmayan tip 2 diyabetik hastalarda serum asimetrik dimetil arjinin, fetuin-A ve ankle-brakial indeks değerlerinin değerlendirilmesi". Ege Tıp Dergisi 58 (2019 ): 397-405
RIS TY - JOUR T1 - Mikroalbüminürisi olan ve olmayan tip 2 diyabetik hastalarda serum asimetrik dimetil arjinin, fetuin-A ve ankle-brakial indeks değerlerinin değerlendirilmesi AU - Aslı Kılavuz , Bakiye Göker , Sumru Savaş , Çığır Biray Avcı , Fulden Saraç , Cumhur Gündüz Y1 - 2019 PY - 2019 N1 - doi: 10.19161/etd.623697 DO - 10.19161/etd.623697 T2 - Ege Tıp Dergisi JF - Journal JO - JOR SP - 397 EP - 405 VL - 58 IS - 4 SN - 1016-9113-2147-6500 M3 - doi: 10.19161/etd.623697 UR - https://doi.org/10.19161/etd.623697 Y2 - 2019 ER -
EndNote %0 Ege Tıp Dergisi Mikroalbüminürisi olan ve olmayan tip 2 diyabetik hastalarda serum asimetrik dimetil arjinin, fetuin-A ve ankle-brakial indeks değerlerinin değerlendirilmesi %A Aslı Kılavuz , Bakiye Göker , Sumru Savaş , Çığır Biray Avcı , Fulden Saraç , Cumhur Gündüz %T Mikroalbüminürisi olan ve olmayan tip 2 diyabetik hastalarda serum asimetrik dimetil arjinin, fetuin-A ve ankle-brakial indeks değerlerinin değerlendirilmesi %D 2019 %J Ege Tıp Dergisi %P 1016-9113-2147-6500 %V 58 %N 4 %R doi: 10.19161/etd.623697 %U 10.19161/etd.623697
ISNAD Kılavuz, Aslı , Göker, Bakiye , Savaş, Sumru , Biray Avcı, Çığır , Saraç, Fulden , Gündüz, Cumhur . "Mikroalbüminürisi olan ve olmayan tip 2 diyabetik hastalarda serum asimetrik dimetil arjinin, fetuin-A ve ankle-brakial indeks değerlerinin değerlendirilmesi". Ege Tıp Dergisi 58 / 4 (December 2019): 397-405 . https://doi.org/10.19161/etd.623697
AMA Kılavuz A , Göker B , Savaş S , Biray Avcı Ç , Saraç F , Gündüz C . Mikroalbüminürisi olan ve olmayan tip 2 diyabetik hastalarda serum asimetrik dimetil arjinin, fetuin-A ve ankle-brakial indeks değerlerinin değerlendirilmesi. ETD. 2019; 58(4): 397-405.
Vancouver Kılavuz A , Göker B , Savaş S , Biray Avcı Ç , Saraç F , Gündüz C . Mikroalbüminürisi olan ve olmayan tip 2 diyabetik hastalarda serum asimetrik dimetil arjinin, fetuin-A ve ankle-brakial indeks değerlerinin değerlendirilmesi. Ege Tıp Dergisi. 2019; 58(4): 397-405.
IEEE A. Kılavuz , B. Göker , S. Savaş , Ç. Biray Avcı , F. Saraç and C. Gündüz , "Mikroalbüminürisi olan ve olmayan tip 2 diyabetik hastalarda serum asimetrik dimetil arjinin, fetuin-A ve ankle-brakial indeks değerlerinin değerlendirilmesi", Ege Tıp Dergisi, vol. 58, no. 4, pp. 397-405, Dec. 2020, doi:10.19161/etd.623697

Authors of the Article
Aslı KILAVUZ [1]
Bakiye GÖKER [2]
Sumru SAVAŞ [3]
Çığır BİRAY AVCI [4]
Fulden SARAÇ [5]
Cumhur GÜNDÜZ [6]