The evaluation of the neurocognitive development of the symptomatic West Syndrome patients

Esra Sarigecili; Khatuna Makharoblidze; Mustafa Kömür; Cengiz Okuyaz

doi:10.19161/etd.1209083

EN TR

The evaluation of the neurocognitive development of the symptomatic West Syndrome patients

Abstract

Aim: Our study was aimed to determine both demographic and clinical data of patients with symptomatic West Syndrome (WS) and to monitor their neurocognitive development with Bayley Scales of Infant and Toddler Development Screening Test, third edition (Bayley-III) test. Materials and Methods: Fourteen symptomatic WS patients were included in our study. Clinical and demographic data, electroencephalogram (EEG) findings, treatment response, Bayley III developmental test results were recorded before starting the treatment (T0) and in the 12th months of the treatment (T1 and T12). Results: Patients had a significant increase in Bayley-III test scores in all areas at the end of one year (p <0.05). As the patients' EEGs improved, a statistically significant increase was observed in Bayley-III test scores in all areas (p <0.05). However, when the correlation between seizure control and the Bayley-III test scores were evaluated, there was an improvement only in the language area (p< 0,05); but there was no statistically significant difference in other brain areas (p> 0.05). Conclusion: It has been shown that the neurocognitive level gradually improves even in symptomatic type WS with effective treatment during the follow-up of the disease or with the improvement of the EEG findings and seizure control.

Keywords

Semptomatik West Sendromu olan hastaların nörokognitif gelişimlerinin değerlendirilmesi

Öz

Amaç: Çalışmamız semptomatik West Sendromu tanısı olan hastaların hem demografik hem de klinik profillerinin belirlenmesini ve nörokognitif gelişimlerinin Bayley III gelişim testi ile takip edilmesini amaçladı. Gereç ve Yöntem: 14 semptomatik West Sendromu tanısı olan hasta çalışmaya dahil edildi. Klinik ve demografik verileri, elektroensefelogram (EEG) bulguları, tedavi yanıtları, Bayley III gelişimsel test sonuçları tedaviye başlamadan önce (T0) ve 12.ayda (T12) değerlendirildi. Bulgular: Hastaların Bayley III test skorlarında bir yılın sonunda anlamlı bir artış gösterildi (p<0,05). Hastaların EEG’leri düzeldiği zaman Bayley III test sonuçlarında bütün alanlarda anlamlı bir değişim olduğu görüldü (p<0,05). Ancak nöbet kontrolü ve Bayley III test skorları değerlendirildiğinde sadece dil alanında gelişme olduğu görüldü (p<0,05); ancak diğer alanlarda anlamlı bir değişim görülmedi (p>0,05). Sonuç: Uygun tedavi ve nöbet kontrolü ile nörokognitif düzeyin semptomatik west sendromu olan hastalarda bile giderek gelişebildiği gösterildi.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Esra Sarigecili ^*
0000-0001-8630-4950
Türkiye

Khatuna Makharoblidze
0000-0002-3649-7341
Türkiye

Mustafa Kömür
0000-0001-6453-7323
Türkiye

Cengiz Okuyaz
0000-0001-6391-254X
Türkiye

Yayımlanma Tarihi

12 Aralık 2022

Gönderilme Tarihi

19 Ocak 2022

Kabul Tarihi

16 Mayıs 2022

Yayımlandığı Sayı

Yıl 2022 Cilt: 61 Sayı: 4

DOI

https://doi.org/10.19161/etd.1209083

IZ

https://izlik.org/JA62BM86AU

Kaynak Göster

RIS / Bibtex

Vancouver

1.Esra Sarigecili, Khatuna Makharoblidze, Mustafa Kömür, Cengiz Okuyaz. The evaluation of the neurocognitive development of the symptomatic West Syndrome patients. ETD. 01 Aralık 2022;61(4):586-92. doi:10.19161/etd.1209083