Yara iyileşmesi ve cilt rejenerasyonuna güncel bir yaklaşım: Kök hücre eksozom tedavisi

Ayşegül Taşkıran; Dilek Taşkıran

doi:10.19161/etd.1529743

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Yara iyileşmesi ve cilt rejenerasyonuna güncel bir yaklaşım: Kök hücre eksozom tedavisi

Öz

Yara iyileşme süreci, klinik uygulamada birtakım zorluklarla seyreden uzun bir süreç olup güncel tedavilerin etkileri halen sınırlıdır. Yara iyileşme süreci, hücrelerin göçü ve proliferasyonu, ekstraselüler matriksin yeniden şekillendirilmesi ve anjiyogenez ile ilişkilidir. Çeşitli risk faktörleri, kronik iltihaplanma ve bazı hastalıklar, yetersiz yara kapanmasına yol açarak fibrozisle sonuçlanabilecek bir yara izi oluşmasına neden olabilir. Son yıllarda, mezenkimal kök hücrelerin (MKH) yara iyileşmesi ve cilt yenilenmesi üzerinde güçlü terapötik potansiyele sahip olduğuna dair kanıtlar ortaya çıkmıştır. Ancak, MKH'lerin doğrudan uygulanmasında hala birçok sorunla karşılaşılmaktadır. Bununla birlikte son yıllarda, köken aldığı hücrelerden belirli bileşenler içeren lipid çift tabakalı membran yapısına sahip ve “granüler veziküller” olarak tanımlanan eksozomlar, MKH'ler için mükemmel bir alternatif olarak ortaya çıkmıştır. Çeşitli çalışmalarda özellikle MKH'lerden türetilen eksozomların (MKHE) yaraların iyileşmesi ve cilt rejenerasyonu için faydalı olduğu gösterilmiştir. Eksozomların cilt yaralarını iyileştirme sürecinde etkili olduğu mekanizmalar arasında inflamasyonu hafifletmek, damar oluşumunu uyarmak, epitel hücreleri ve fibroblastların proliferasyon ve göçünü uyarmak yer almaktadır. Bu nedenle, MKHE uygulanması, cilt yaralarının tedavisinde hücre tedavisine umut verici bir alternatif olabilir ve aynı anda birden fazla mekanizma aracılığıyla yara iyileşmesini teşvik edebilir. Bu derlemede, MKH'lerden türetilen eksozomların yara iyileşmesinde ve cilt rejenerasyonundaki rolü ve mekanizmaları hakkında güncel bilgiler sunulacak ve MKHE’lerin klinik uygulamalardaki potansiyelleri ayrıntılı olarak ele alınacaktır.

Anahtar Kelimeler

A current approach to wound healing and skin regeneration: Stem cell exosome therapy

Abstract

The wound healing process is a long and challenging one in clinical practice, with current treatments showing limited effects. The wound healing process is associated with cell migration and proliferation, remodeling of extracellular matrix and angiogenesis. Various risk factors, chronic inflammation, and certain diseases can lead to insufficient wound closure, resulting in scar formation that may lead to fibrosis. In recent years, there has been evidence suggesting that mesenchymal stem cells (MSCs) have significant therapeutic potential for wound healing and skin regeneration. However, the direct application of MSCs still confronts many difficulties. Interestingly, exosomes, identified as “granular vesicles” with a lipid bilayer membrane structure involving specific components from their source cells, may reveal as an perfect alternative to MSCs. Various studies in recent years have shown that exosomes derived from MSCs are useful for wound healing and skin regeneration. The mechanisms by which exosomes are effective in the wound healing process include relieving inflammation, promoting vascularization, and the proliferation of epithelial cells and fibroblasts. Therefore, the application of MSC-exosomes may be a promising alternative to cell therapy in the treatment of skin wounds. This review will present current literature on the role and mechanisms of MSC-exosomes in wound healing and skin regeneration and will elaborate on the clinical potential of MSC-exosomes.

Keywords

Destekleyen Kurum

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Proje Numarası

Yok

Etik Beyan

Yok

Teşekkür

Yok

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Tıbbi Fizyoloji (Diğer)

Bölüm

Derleme

Yazarlar

Ayşegül Taşkıran
0009-0007-6160-6566
Türkiye

Dilek Taşkıran ^*
0000-0002-4505-0939
Türkiye

Yayımlanma Tarihi

9 Aralık 2024

Gönderilme Tarihi

7 Ağustos 2024

Kabul Tarihi

25 Ağustos 2024

Yayımlandığı Sayı

Yıl 2024 Cilt: 63 Sayı: 4

DOI

https://doi.org/10.19161/etd.1529743

IZ

https://izlik.org/JA78UJ52LC

Kaynak Göster

RIS / Bibtex

Vancouver

1.Ayşegül Taşkıran, Dilek Taşkıran. Yara iyileşmesi ve cilt rejenerasyonuna güncel bir yaklaşım: Kök hücre eksozom tedavisi. ETD. 01 Aralık 2024;63(4):635-43. doi:10.19161/etd.1529743