The role of stem cells and biomaterials in peripheral nervous system regeneration

Dila Hatun Sal; Zeynep Simge Yılmaz; Büşra Horuz; Aybike Berrak Özdemir; Kubilay Doğan Kılıç

doi:10.19161/etd.1532925

EN TR

The role of stem cells and biomaterials in peripheral nervous system regeneration

Abstract

Peripheral nerve injuries present significant challenges to patients and require intensive and costly treatments. The utilization of biomaterials is an effective treatment method. Personalized biomaterials are promising for the regeneration of damaged peripheral nerves. Stem cells have an important role in modern treatment methods because of their properties and promise to solve diseases requiring tissue regeneration, such as peripheral nerve damage. In this review, we aimed to investigate the relationship between stem cells and biomaterials, considering their different origins and potential compatibility in facilitating the regeneration of peripheral nerve injury.

Keywords

Kaynakça

Vijayavenkataraman S. Nerve guide conduits for peripheral nerve injury repair: A review on design, materials and fabrication methods. Acta Biomater. 2020;106:54–69. https://doi.org/10.1016/j.actbio.2020.02.003
Gordon T. Peripheral nerve regeneration and muscle reinnervation. Int J Mol Sci. 2020;21(22):8652. https://doi.org/10.3390/ijms21228652
Min Q, Parkinson DB, Dun XP. Migrating Schwann cells direct axon regeneration within the peripheral nerve bridge. Glia. 2021;69(2):235–254. https://doi.org/10.1002/glia.23892
Thau L, Reddy V, Singh P. Anatomy, Central Nervous System. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542179/
Alkan İ, Bekar E, Altunkaynak Z. Periferik Sinir Yaralanmaları ve Rejenerasyonu. Ahi Evran Med J. 2022;6(2):211-19. https://doi.org/10.46332/aemj.975395
Mescher A. Junqueira's Basic Histology: Text and Atlas, Fourteenth Edition. Yunanistan: McGraw-Hill Education; 2015.
Allen NJ, Lyons DA. Glia as architects of central nervous system formation and function. Science. 2018;362(6411):181–85. https://doi.org/10.1126/science.aat0473
Ünlükal N. Sinir Dokusuna Genel Bakış. In: Taş F. Nörobilim Alanında Multidisipliner Yaklaşımlar. Iksad Yayınevi; 2021. p. 3-18.

Guillamón-Vivancos T, Gómez-Pinedo U, Matías-Guiu J. Astrocytes in neurodegenerative diseases (I): function and molecular description. Neurologia. 2015;30(2):119–29. https://doi.org/10.1016/j.nrl.2012.12.007
Kipp M. Oligodendrocyte Physiology and Pathology Function. Cells. 2020;9(9):2078. https://doi.org/10.3390/cells9092078
Nelles DG, Hazrati LN. The pathological potential of ependymal cells in mild traumatic brain injury. Front Cell Neurosci. 2023;17:1216420. https://doi.org/10.3389/fncel.2023.1216420
Colonna M, Butovsky O. Microglia Function in the Central Nervous System During Health and Neurodegeneration. Annu Rev Immunol. 2017;35:441–68. https://doi.org/10.1146/annurev-immunol-051116-052358
Bosch-Queralt M, Fledrich R, Stassart RM. Schwann cell functions in peripheral nerve development and repair. Neurobiol Dis. 2023;176:105952. https://doi.org/10.1016/j.nbd.2022.105952
Jessen KR. Glial cells. Int J Biochem Cell Biol. 2004;36(10):1861–67. https://doi.org/10.1016/j.biocel.2004.02.023
Seguella L, Gulbransen BD. Enteric glial biology, intercellular signalling and roles in gastrointestinal disease. Nat Rev Gastroenterol Hepatol. 2021;18(8):571–87. https://doi.org/10.1038/s41575-021-00423-7
Zeng W, Yang F, Shen WL, Zhan C, Zheng P, Hu J. Interactions between the central nervous system and peripheral metabolic organs. Sci China Life Sci. 2022;65(10):1929–58. https://doi.org/10.1007/s11427-021-2103-5
Lopes B, Sousa P, Alvites R, Branquinho M, Sousa AC, Mendonça C, et al. Peripheral Nerve Injury Treatments and Advances: One Health Perspective. Int J Mol Sci. 2022;23(2):918. https://doi.org/10.3390/ijms23020918
Pabari A, Yang SY, Seifalian AM, Mosahebi A. Modern surgical management of peripheral nerve gap. J Plast Reconstr Aesthet Surg. 2010;63(12):1941-48. https://doi.org/10.1016/j.bjps.2009.12.010
Gibbons C.H. Basics of autonomic nervous system function. Handb Clin Neurol. 2019;160:407–18. https://doi.org/10.1016/B978-0-444-64032-1.00027-8
Modrak M, Talukder MAH, Gurgenashvili K, Noble M, Elfar JC. Peripheral nerve injury and myelination: Potential therapeutic strategies. J Neurosci Res. 2020;98(5):780–95. https://doi.org/10.1002/jnr.24538
Zhang Y, Zhao Q, Chen Q, Xu L, Yi S. Transcriptional Control of Peripheral Nerve Regeneration. Mol Neurobiol. 2023;60(1):329–41. https://doi.org/10.1007/s12035-022-03090-0
Zhang PX, Yin XF, Kou YH, Xue F, Han N, Jiang BG. Neural regeneration after peripheral nerve injury repair is a system remodelling process of interaction between nerves and terminal effector. Neural Regen Res. 2015;10(1):52. https://doi.org/10.4103/1673-5374.150705
Dubový P. Wallerian degeneration and peripheral nerve conditions for both axonal regeneration and neuropathic pain induction. Ann Anat. 2011;193(4):267-75. https://doi.org/10.1016/j.aanat.2011.02.011
Chen P, Piao X, Bonaldo P. Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury. Acta Neuropathol. 2015;130:605-18. https://doi.org/10.1007/s00401-015-1482-4
Wan T, Zhang FS, Qin MY, Jiang HR, Zhang M, Qu Y, et al. Growth factors: Bioactive macromolecular drugs for peripheral nerve injury treatment - Molecular mechanisms and delivery platforms. Biomed Pharmacother. 2024;170:116024. https://doi.org/10.1016/j.biopha.2023.116024
Song S, McConnell KW, Amores D, Levinson A, Vogel H, Quarta M, et al. Electrical stimulation of human neural stem cells via conductive polymer nerve guides enhances peripheral nerve recovery. Biomaterials. 2021;275:120982. https://doi.org/10.1016/j.biomaterials.2021.120982
Salles MB, Horikawa FK, Allegrini S Jr, Zangrando D, Yoshimoto M, Shinohara EH. Clinical evaluation of the perception of post-trauma paresthesia in the mandible, using a biomimetic material: A preliminary study in humans. Heliyon. 2023;9(8). https://doi.org/10.1016/j.heliyon.2023.e18304
Modrak M, Talukder MH, Gurgenashvili K, Noble M, Elfar JC. Peripheral nerve injury and myelination: Potential therapeutic strategies. J Neurosci Res. 2020;98(5):780-95. https://doi.org/10.1002/jnr.24538
Meng Q, Burrell JC, Zhang Q, Le AD. Potential Application of Orofacial MSCs in Tissue Engineering Nerve Guidance for Peripheral Nerve Injury Repair. Stem Cell Rev Rep. 2023;19(8):2612-31. https://doi.org/10.1007/s12015-023-10609-y
Zhang RC, Du WQ, Zhang JY, Yu SX, Lu FZ, Ding HM, et al. Mesenchymal stem cell treatment for peripheral nerve injury: a narrative review. Neural Regen Res. 2021;16(11):2170. https://doi.org/10.4103/1673-5374.310941
Sullivan R, Dailey T, Duncan K, Abel N, Borlongan CV. Peripheral nerve injury: stem cell therapy and peripheral nerve transfer. Int J Mol Sci. 2016;17(12):2101. https://doi.org/10.3390%2Fijms17122101
Kubiak CA, Grochmal J, Kung TA, Cederna PS, Midha R, Kemp SW. Stem-cell-based therapies to enhance peripheral nerve regeneration. Muscle Nerve. 2020;61(4):449-59. https://doi.org/10.1002/mus.26760
Dong R, Liu Y, Yang Y, Wang H, Xu Y, Zhang Z. MSC-derived exosomes-based therapy for peripheral nerve injury: a novel therapeutic strategy. Biomed Res Int 2019;2019:6458237. https://doi.org/10.1155/2019/6458237
Fairbairn NG, Meppelink AM, Ng-Glazier J, Randolph MA, Winograd JM. Augmenting peripheral nerve regeneration using stem cells: a review of current opinion. World J Stem Cells 2015;7(1):11. https://doi.org/10.4252%2Fwjsc.v7.i1.11
Yi S, Zhang Y, Gu X, Huang L, Zhang K, Qian T, et al. Application of stem cells in peripheral nerve regeneration. Burns Trauma 2020;8 https://doi.org/10.1093%2Fburnst%2Ftkaa002
Kim D, Lee AE, Xu Q, Zhang Q, Le AD. Gingiva-derived mesenchymal stem cells: potential application in tissue engineering and regenerative medicine—a comprehensive review. Front Immunol 2021;12:667221. https://doi.org/10.3389/fimmu.2021.667221
Fathi SS, Zaminy A. Stem cell therapy for nerve injury. World J Stem Cells 2017;9(9):144. https://doi.org/10.4252/wjsc.v9.i9.144
Alvites RD, Branquinho MV, Sousa AC, Lopes B, Sousa P, Prada J, et al. Effects of olfactory mucosa stem/stromal cell and olfactory ensheathing cells secretome on peripheral nerve regeneration. Biomolecules 2022;12(6):818. https://doi.org/10.3390%2Fbiom12060818
Alvites RD, Caseiro AR, Pedrosa SS, Branquinho ME, Varejão AS, Maurício AC. The nasal cavity of the rat and mouse-source of mesenchymal stem cells for treatment of peripheral nerve injury. Anat Rec 2018;301(10):1678-1689. https://doi.org/10.1002/ar.23844
Sumarwoto T, Suroto H, Mahyudin F, Utomo DN, Tinduh D, Notobroto HB, et al. Role of adipose mesenchymal stem cells and secretome in peripheral nerve regeneration. Ann Med Surg (Lond) 2021;67:102482. https://doi.org/10.1016/j.amsu.2021.102482
Berrocal YA, Almeida VW, Gupta R, Levi AD. Transplantation of Schwann cells in a collagen tube for the repair of large, segmental peripheral nerve defects in rats. J Neurosurg 2013;119(3):720-732. https://doi.org/10.3171/2013.4.JNS121189
Bozkurt A, van Neerven SG, Claeys KG, O'Dey DM, Sudhoff A, Brook GA, et al. The proximal medial sural nerve biopsy model: a standardised and reproducible baseline clinical model for the translational evaluation of bioengineered nerve guides. Biomed Res Int 2014;2014:121452. https://doi.org/10.1155/2014/121452
Saeki M, Tanaka K, Imatani J, Okamoto H, Watanabe K, Nakamura T, et al. Efficacy and safety of novel collagen conduits filled with collagen filaments to treat patients with peripheral nerve injury: a multicenter, controlled, open-label clinical trial. Injury 2018;49(4):766-774. https://doi.org/10.1016/j.injury.2018.03.011
Neubrech F, Sauerbier M, Moll W, Seegmüller J, Heider S, Harhaus L, et al. Enhancing the outcome of traumatic sensory nerve lesions of the hand by additional use of a chitosan nerve tube in primary nerve repair: a randomized controlled bicentric trial. Plast Reconstr Surg 2018;142(2):415-424. https://doi.org/10.1097/PRS.0000000000004574
Dastagir K, Radtke C, Dastagir N, Bucan V, Strauß S, Jokuszies A, et al. A new standardized clinical model for evaluation of nerve guides: a single-blinded randomized controlled prospective study. Plast Reconstr Surg 2022;150(6):1298-1306. https://doi.org/10.1097/PRS.0000000000009677
Atzei A, Calcagni M, Breda B, Fasolo G, Pajardi G, Cugola L. Clinical evaluation of a hyaluronan-based gel following microsurgical reconstruction of peripheral nerves of the hand. Microsurgery 2007;27(1):2-7. https://doi.org/10.1002/micr.20299

Ayrıntılar

Birincil Dil

İngilizce

Konular

Periferik Sinir Sistemi

Bölüm

Derleme

Yazarlar

Dila Hatun Sal ^*
0009-0007-3840-6347
United Kingdom

Zeynep Simge Yılmaz
0000-0002-1460-8530
Türkiye

Büşra Horuz
0009-0009-6203-4111
Türkiye

Aybike Berrak Özdemir
0009-0006-9488-1524
Türkiye

Kubilay Doğan Kılıç
0000-0002-9484-0777
Türkiye

Yayımlanma Tarihi

10 Haziran 2025

Gönderilme Tarihi

13 Ağustos 2024

Kabul Tarihi

17 Ekim 2024

Yayımlandığı Sayı

Yıl 1970 Cilt: 64 Sayı: 2

DOI

https://doi.org/10.19161/etd.1532925

IZ

https://izlik.org/JA79YJ28SY

Kaynak Göster

RIS / Bibtex

Vancouver

1.Dila Hatun Sal, Zeynep Simge Yılmaz, Büşra Horuz, Aybike Berrak Özdemir, Kubilay Doğan Kılıç. The role of stem cells and biomaterials in peripheral nervous system regeneration. ETD. 01 Haziran 2025;64(2):402-14. doi:10.19161/etd.1532925

Periferik sinir sistemi yenilenmesinde kök hücre ve biyomateryallerin rolü

The role of stem cells and biomaterials in peripheral nervous system regeneration

Abstract

Keywords

Periferik sinir sistemi yenilenmesinde kök hücre ve biyomateryallerin rolü

Öz

Anahtar Kelimeler

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster