The role of biochemical markers in predicting pre-eclampsia

Ufuk Atlıhan; Begüm Ertan; Mehmet Emre Peker; Can Ata; Onur Yavuz; Hüseyin Aytuğ Avşar; Alper İleri; Tevfik Berk Bıldacı; Selçuk Erkılınç

doi:10.19161/etd.1608129

EN TR

The role of biochemical markers in predicting pre-eclampsia

Öz

Aim: The aim of our study was to evaluate the role of biochemical markers in predicting preeclampsia. Materials and Methods: 7240 women whose pregnancy follow-ups and deliveries were carried out by us between March 2018 and March 2024 were retrospectively screened. Patients in the study group consisted of 102 women diagnosed with preeclampsia at <34 weeks of gestation, and patients in the control group consisted of 118 women who gave birth at ≥37 weeks of gestation. Demographic characteristics and obstetric and biochemical outcomes of the two groups were compared with each other. Results: The body mass index (BMI) value was significantly higher in the preeclampsia group compared with the controls group (p=0.016). The birth weight value was significantly lower in the preeclampsia group compared with the controls group (p<0.001). The gestational week at delivery was significantly lower in the preeclampsia group compared with the controls group (p<0.001). Lymphocyte and platelet counts were significantly lower in the preeclampsia group compared with the controls group (p<0.001 and p<0.001, respectively). NLR and SII value were significantly higher in the preeclampsia group compared with the controls group (p=0.022, p<0.001, respectively). Conclusion: Our study reveals important clinical and laboratory differences in preeclamptic pregnancies. Increased inflammatory markers were found to be a feature of preeclamptic pregnancies and are consistent with the existing literature. Our findings can be used to determine early diagnosis and comprehensive management strategies to minimize the risks associated with preeclampsia.

Anahtar Kelimeler

Preeklampsiyi öngörmede biyokimyasal belirteçlerin rolü

Öz

Amaç: Çalışmamızın amacı preeklampsiyi öngörmede biyokimyasal belirteçlerin rolünü değerlendirmektir. Gereç ve Yöntem: Mart 2018 - 2024 tarihleri arasında gebelik takipleri ve doğumları tarafımızca gerçekleştirilen 7240 kadın retrospektif olarak tarandı. Çalışma grubundaki hastalar <34 gebelik haftasında preeklampsi tanısı konulan 102 kadından, kontrol grubundaki hastalar ise ≥37 gebelik haftasında doğum yapan 118 kadından oluştu. İki grubun demografik özellikleri, obstetrik ve biyokimyasal sonuçları birbirleriyle karşılaştırıldı. Bulgular: Preeklampsi grubunda vücut kitle indeksi kontrol grubuna göre anlamlı yüksek saptandı (p=0.016). Doğum ağırlığı preeklampsi grubunda kontrol grubuna göre anlamlı düşük saptandı (p<0.001). Doğumdaki gebelik haftası preeklampsi grubunda kontrol grubuna göre anlamlı düşük saptandı (p<0.001). Lenfosit ve trombosit sayıları preeklampsi grubunda kontrol grubuna göre anlamlı düşük saptandı (p<0.001 ve p<0.001, sırasıyla). NLR ve SII değeri preeklampsi grubunda kontrol grubuna göre anlamlı yüksek saptandı (p=0.022, p<0.001, sırasıyla). Sonuç: Çalışmamız, preeklamptik gebelerde önemli klinik ve laboratuvar farklılıklarını ortaya koymaktadır. Artmış inflamatuar belirteçlerin preeklamptik gebeliklerin bir özelliği olduğu bulunmuştur ve mevcut literatürle tutarlıdır. Bulgularımız, preeklampsi ile ilişkili riskleri en aza indirmek için erken tanı ve kapsamlı yönetim stratejilerini belirlemek için kullanılabilir.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Kadın Hastalıkları ve Doğum

Bölüm

Araştırma Makalesi

Yazarlar

Ufuk Atlıhan ^*
0000-0002-2109-1373
Türkiye

Begüm Ertan
0000-0002-0370-7509
Türkiye

Mehmet Emre Peker
0000-0002-3344-2935
Türkiye

Can Ata
0000-0002-0841-0480
Türkiye

Onur Yavuz
0000-0003-3716-2145
Türkiye

Hüseyin Aytuğ Avşar
0000-0003-0636-3104
Türkiye

Alper İleri
0000-0002-4713-5805
Türkiye

Tevfik Berk Bıldacı
0000-0002-6432-6777
Türkiye

Selçuk Erkılınç
0000-0002-6512-9070
Türkiye

Yayımlanma Tarihi

10 Haziran 2025

Gönderilme Tarihi

27 Aralık 2024

Kabul Tarihi

10 Mart 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 64 Sayı: 2

DOI

https://doi.org/10.19161/etd.1608129

IZ

https://izlik.org/JA92RF75CX

Kaynak Göster

RIS / Bibtex

APA

Atlıhan, U., Ertan, B., Peker, M. E., Ata, C., Yavuz, O., Avşar, H. A., İleri, A., Bıldacı, T. B., & Erkılınç, S. (2025). The role of biochemical markers in predicting pre-eclampsia. Ege Tıp Dergisi, 64(2), 324-329. https://doi.org/10.19161/etd.1608129

AMA

1.Atlıhan U, Ertan B, Peker ME, vd. The role of biochemical markers in predicting pre-eclampsia. ETD. 2025;64(2):324-329. doi:10.19161/etd.1608129

Chicago

Atlıhan, Ufuk, Begüm Ertan, Mehmet Emre Peker, vd. 2025. “The role of biochemical markers in predicting pre-eclampsia”. Ege Tıp Dergisi 64 (2): 324-29. https://doi.org/10.19161/etd.1608129.

EndNote

Atlıhan U, Ertan B, Peker ME, Ata C, Yavuz O, Avşar HA, İleri A, Bıldacı TB, Erkılınç S (01 Haziran 2025) The role of biochemical markers in predicting pre-eclampsia. Ege Tıp Dergisi 64 2 324–329.

IEEE

[1]U. Atlıhan vd., “The role of biochemical markers in predicting pre-eclampsia”, ETD, c. 64, sy 2, ss. 324–329, Haz. 2025, doi: 10.19161/etd.1608129.

ISNAD

Atlıhan, Ufuk - Ertan, Begüm - Peker, Mehmet Emre - Ata, Can - Yavuz, Onur - Avşar, Hüseyin Aytuğ - İleri, Alper - Bıldacı, Tevfik Berk - Erkılınç, Selçuk. “The role of biochemical markers in predicting pre-eclampsia”. Ege Tıp Dergisi 64/2 (01 Haziran 2025): 324-329. https://doi.org/10.19161/etd.1608129.

JAMA

1.Atlıhan U, Ertan B, Peker ME, Ata C, Yavuz O, Avşar HA, İleri A, Bıldacı TB, Erkılınç S. The role of biochemical markers in predicting pre-eclampsia. ETD. 2025;64:324–329.

MLA

Atlıhan, Ufuk, vd. “The role of biochemical markers in predicting pre-eclampsia”. Ege Tıp Dergisi, c. 64, sy 2, Haziran 2025, ss. 324-9, doi:10.19161/etd.1608129.

Vancouver

1.Ufuk Atlıhan, Begüm Ertan, Mehmet Emre Peker, Can Ata, Onur Yavuz, Hüseyin Aytuğ Avşar, Alper İleri, Tevfik Berk Bıldacı, Selçuk Erkılınç. The role of biochemical markers in predicting pre-eclampsia. ETD. 01 Haziran 2025;64(2):324-9. doi:10.19161/etd.1608129