Araştırma Makalesi

Investigation of the relationship of lysyl oxidases on neck metastasis and prognosis in early stage oral cavity cancers.

Cilt: 64 Sayı: 3 8 Eylül 2025
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Investigation of the relationship of lysyl oxidases on neck metastasis and prognosis in early stage oral cavity cancers.

Abstract

Introduction: Cancers of the lip and tongue are the sixteenth most common malignancy worldwide, with 377,713 new cases per year. Despite the decrease in smoking, early diagnosis, and advances in adjuvant treatment methods, significant increases in tongue cancers incidence are observed in western society, especially in young adults. This study aims to investigate the effect of LOX and LOXL-2 expression in tumor cells of patients operated on for early-stage T1-T2 tongue cancer on neck metastasis and prognosis. Methods: A total of 43 patients, 22 N(+) and 21 N(-) operated for T1-T2 tongue cancer were included in the study. He sought to discover cytoplasmic level LOX and LOXL-2 in the paraffin sections of subjects. The relationship of LOX and LOXL-2 cases with tumor T stage, N stage, recurrence, and survival outcomes were analyzed. Results: A total of 43 patients, 22 N(+) and 21 N(-) operated for T1-T2 tongue cancer were included in the study. LOX expression was observed in 16 patients (n=43, 37.2%) (12 N(+) and 4 N(-)) and in 15 patients (n=43, 34.8%) (12N(+) and 3 N(-) )) LOXL-2 expression was detected. In the analysis performed according to LOX and LOXL-2 expression, it was determined that LOX and LOXL-2 expression was statistically significantly higher in the group with tumor stage T1 than in those with T2 and in the N(+) group with pathological lymph nodes in the neck compared to those with N(-) (p <0.05). The cytoplasmic staining rate of LOX and LOXL-2 expression in neoplastic cells was found to be statistically significantly higher in patients with recurrence (p <0.05). Conclusion: In our study, high LOX and LOXL-2 expression has been shown to have a statistically significant effect on regional recurrence, neck lymph node metastasis, and survival time. Our study will guide researchers in terms of both the development of new targeted biological agents and the creation of individualized follow-up and treatment protocols.

Keywords

Destekleyen Kurum

Ege Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü

Proje Numarası

22870

Kaynakça

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  7. Yuen,A.P.W.,Wei,W.I.,Wong,Y.M.,&Tang,K.C.(1997).Electiveneckdissectionversusobservationinthetreatmentofearlyoraltonguecarcinoma.Head&Neck:JournalfortheSciencesandSpecialtiesoftheHeadandNeck,19(7),583-588.ISO690
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Ayrıntılar

Birincil Dil

İngilizce

Konular

Kulak Burun Boğaz

Bölüm

Araştırma Makalesi

Yazarlar

Yayımlanma Tarihi

8 Eylül 2025

Gönderilme Tarihi

28 Ocak 2025

Kabul Tarihi

24 Nisan 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 64 Sayı: 3

DOI

https://doi.org/10.19161/etd.1622224

IZ

https://izlik.org/JA53WA72YR

Kaynak Göster

RIS / Bibtex
Vancouver
1.Vahdettin Emre Şahin, Kerem Öztürk, Goksel Turhal, Ali Veral. Investigation of the relationship of lysyl oxidases on neck metastasis and prognosis in early stage oral cavity cancers. ETD. 01 Eylül 2025;64(3):431-7. doi:10.19161/etd.1622224

Cited By

Investigation of the relationship of lysyl oxidases on neck metastasis and prognosis in early stage oral cavity cancers

Ege Tıp Dergisi

https://doi.org/10.19161/etd.1838972

Ege Tıp Dergisi, makalelerin Atıf-Gayri Ticari-Aynı Lisansla Paylaş 4.0 Uluslararası (CC BY-NC-SA 4.0) lisansına uygun bir şekilde paylaşılmasına izin verir.