Investigation of the relationship of lysyl oxidases on neck metastasis and prognosis in early stage oral cavity cancers.

Vahdettin Emre Şahin; Kerem Öztürk; Goksel Turhal; Ali Veral

doi:10.19161/etd.1622224

TR EN

Erken evre oral kavite kanserlerinde lizil oksidazların boyun metastazı ve prognoz üzerine ilişkisinin araştırılması.

Öz

Giriş: Dudak ve dil kanserleri, yılda 377.713 yeni vakayla dünya çapında en sık görülen on altıncı malignitedir. Sigara kullanımının azalmasına, erken tanıya ve adjuvan tedavi yöntemlerindeki ilerlemelere rağmen batı toplumunda özellikle genç erişkinlerde dil kanserlerinin görülme sıklığında önemli artışlar görülmektedir. Bu çalışmada erken evre T1-T2 dil kanseri nedeniyle ameliyat edilen hastaların tümör hücrelerinde LOX ve LOXL-2 ekspresyonunun boyun metastazı ve prognoz üzerine etkisinin araştırılması amaçlandı. Yöntem: Çalışmaya T1-T2 dil kanseri nedeniyle opere edilen 22 N(+) ve 21 N(-) olmak üzere toplam 43 hasta dahil edildi. Deneklerin parafin kesitlerinde sitoplazmik LOX ve LOXL-2 seviyeleri araştırıldı. LOX ve LOXL-2 vakalarının tümör T evresi, N evresi, nüks ve sağkalım sonuçları ile ilişkisi analiz edildi. Bulgular: Çalışmaya T1-T2 dil kanseri nedeniyle opere edilen 22 N(+) ve 21 N(-) olmak üzere toplam 43 hasta dahil edildi. LOX ekspresyonu 16 hastada (n=43, %37,2) [12 N(+) ve 4 N(-)] ve LOXL-2 ekspresyonu ise 15 hastada (n=43, %34,8) [12N(+) ve 3 N(-)] tespit edildi. LOX ve LOXL-2 ekspresyonuna göre yapılan analizde LOX ve LOXL-2 ekspresyonunun tümör evresi T1 olan grupta T2 olanlara göre ve boyunda mestastatik lenf nodu bulunan N(+) grupta istatistiksel olarak anlamlı derecede yüksek olduğu belirlendi (p < 0,05). Neoplastik hücrelerde LOX ve LOXL-2 ekspresyonunun sitoplazmik boyanma oranı nüks olan hastalarda istatistiksel olarak anlamlı derecede yüksek bulundu (p<0.05). Sonuç: Çalışmamızda yüksek LOX ve LOXL-2 ekspresyonunun lokal nüks, boyun lenf nodu metastazı ve sağkalım süresi üzerine istatistiksel olarak anlamlı etkisi olduğu gösterilmiştir. Çalışmamız hem hedefe yönelik yeni biyolojik ajanların geliştirilmesi hem de kişiye özel takip ve tedavi protokollerinin oluşturulması açısından araştırmacılara yol gösterecektir.

Anahtar Kelimeler

Investigation of the relationship of lysyl oxidases on neck metastasis and prognosis in early stage oral cavity cancers.

Abstract

Introduction: Cancers of the lip and tongue are the sixteenth most common malignancy worldwide, with 377,713 new cases per year. Despite the decrease in smoking, early diagnosis, and advances in adjuvant treatment methods, significant increases in tongue cancers incidence are observed in western society, especially in young adults. This study aims to investigate the effect of LOX and LOXL-2 expression in tumor cells of patients operated on for early-stage T1-T2 tongue cancer on neck metastasis and prognosis. Methods: A total of 43 patients, 22 N(+) and 21 N(-) operated for T1-T2 tongue cancer were included in the study. He sought to discover cytoplasmic level LOX and LOXL-2 in the paraffin sections of subjects. The relationship of LOX and LOXL-2 cases with tumor T stage, N stage, recurrence, and survival outcomes were analyzed. Results: A total of 43 patients, 22 N(+) and 21 N(-) operated for T1-T2 tongue cancer were included in the study. LOX expression was observed in 16 patients (n=43, 37.2%) (12 N(+) and 4 N(-)) and in 15 patients (n=43, 34.8%) (12N(+) and 3 N(-) )) LOXL-2 expression was detected. In the analysis performed according to LOX and LOXL-2 expression, it was determined that LOX and LOXL-2 expression was statistically significantly higher in the group with tumor stage T1 than in those with T2 and in the N(+) group with pathological lymph nodes in the neck compared to those with N(-) (p <0.05). The cytoplasmic staining rate of LOX and LOXL-2 expression in neoplastic cells was found to be statistically significantly higher in patients with recurrence (p <0.05). Conclusion: In our study, high LOX and LOXL-2 expression has been shown to have a statistically significant effect on regional recurrence, neck lymph node metastasis, and survival time. Our study will guide researchers in terms of both the development of new targeted biological agents and the creation of individualized follow-up and treatment protocols.

Keywords

Supporting Institution

Ege Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü

Project Number

22870

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Details

Primary Language

English

Subjects

Otorhinolaryngology

Journal Section

Research Article

Authors

Vahdettin Emre Şahin ^*
0000-0001-7490-8212
Türkiye

Kerem Öztürk
0000-0003-4608-6105
Türkiye

Goksel Turhal
0000-0003-0020-1921
Türkiye

Ali Veral
0000-0003-0343-9978
Türkiye

Publication Date

September 8, 2025

Submission Date

January 28, 2025

Acceptance Date

April 24, 2025

Published in Issue

Year 2025 Volume: 64 Number: 3

DOI

https://doi.org/10.19161/etd.1622224

IZ

https://izlik.org/JA53WA72YR

Cite

RIS / Bibtex

Vancouver

1.Vahdettin Emre Şahin, Kerem Öztürk, Goksel Turhal, Ali Veral. Investigation of the relationship of lysyl oxidases on neck metastasis and prognosis in early stage oral cavity cancers. EJM. 2025 Sep. 1;64(3):431-7. doi:10.19161/etd.1622224

Cited By

Investigation of the relationship of lysyl oxidases on neck metastasis and prognosis in early stage oral cavity cancers

Ege Tıp Dergisi

https://doi.org/10.19161/etd.1838972