Olgu Sunumu

A case of myasthenia gravis emerging after prior diagnosis of CIDP: Clinical challenges in overlapping autoimmune disorders

Cilt: 64 Sayı: 4 8 Aralık 2025
PDF İndir
TR EN

A case of myasthenia gravis emerging after prior diagnosis of CIDP: Clinical challenges in overlapping autoimmune disorders

Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) and myasthenia gravis (MG) are distinct autoimmune neuromuscular disorders that rarely coexist. We present a 52-year-old man with stable CIDP who developed progressive lower limb weakness and facial involvement. Electrophysiological studies revealed neuromuscular junction dysfunction, and elevated acetylcholine receptor antibodies confirmed MG. Treatment with pyridostigmine, intravenous immunoglobulin, and rituximab resulted in clinical stabilization. This case shows the importance of considering overlapping autoimmune disorders in CIDP patients with new or atypical symptoms. Early recognition using electrophysiological and serological tests is important for accurate diagnosis and effective management of coexisting CIDP and MG.

Keywords

Kaynakça

  1. Mathey EK, Park SB, Hughes RA, et al. Chronic inflammatory demyelinating polyradiculoneuropathy: from pathology to phenotype. J Neurol Neurosurg Psychiatry. 2015;86:973- 985. doi:10.1136/jnnp-2014.
  2. Meriggioli MN, Sanders DB. Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity. Lancet Neurol. 2009;8:475-490.doi:10.1016/S1474-4422(09)70063-8.
  3. Sanders DB, Wolfe GI, Benatar M, et al. International consensus guidance for management of myasthenia gravis: Executive summary. Neurology. 2016;87:419-425. doi:10.1212/WNL.0000000000002790.
  4. Weinreb H, Klein J, Kupersmith M. Ocular myasthenia gravis and chronic inflammatory polyradiculoneuropathy. N Y State J Med 1986;86:439 – 42.
  5. Inatsu A, Ohi T, Shioya K, Matsukura S. A case of myasthenia gravis occurring in the period of remission of chronic inflammatory demyelinating polyradiculoneuropathy. Rinsho Shinkeigaku 1992;32: 878 – 879.
  6. Patwa HS, Fecko JF, Goldstein JM. Concurrent myasthenia gravis and chronic inflammatory demyelinating polyneuropathy. Muscle Nerve. 1996;19:1059-1060.
  7. Sempere AP, Claveria LE, Cru4Martine4 A, et al. Myasthenia gravis and chronic inflammatory demyelinating polyneuropathy. Eur J Neurol. 19964;3:397398.
  8. Kimura K, Nezu A, Kimura S, et al. A case of myasthenia gravis in childhood associated with chronic inflammatory demyelinating polyradiculoneuropathy. Neuropediatrics. 1998;29:108-112. doi:10.1055/s-2007-973544.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Nöroloji ve Nöromüsküler Hastalıklar

Bölüm

Olgu Sunumu

Yayımlanma Tarihi

8 Aralık 2025

Gönderilme Tarihi

11 Temmuz 2025

Kabul Tarihi

30 Eylül 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 64 Sayı: 4

Kaynak Göster

Vancouver
1.Şeyma Aykaç, Abdullah Arı, Birgül Dere, Yaprak Seçil, Ayşe Nur Yüceyar. A case of myasthenia gravis emerging after prior diagnosis of CIDP: Clinical challenges in overlapping autoimmune disorders. ETD. 01 Aralık 2025;64(4):716-20. doi:10.19161/etd.1736794

Ege Tıp Dergisi, makalelerin Atıf-Gayri Ticari-Aynı Lisansla Paylaş 4.0 Uluslararası (CC BY-NC-SA 4.0) lisansına uygun bir şekilde paylaşılmasına izin verir.