Araştırma Makalesi

Selective arterial embolization for renal angiomyolipoma: The role of optimal embolization

Cilt: 65 Sayı: 3 3 Eylül 2026
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Selective arterial embolization for renal angiomyolipoma: The role of optimal embolization

Öz

Aim: The study aims to evaluate the efficacy and safety of selective arterial embolization (SAE) for renal angiomyolipoma (rAML). Material and Methods: This retrospective study included patients with rAML who underwent SAE between February 2009 and December 2022. The primary outcome was procedural success, defined as cessation of bleeding and reduction in tumor size. Secondary outcomes included complication rates, changes in symptoms, and the need for reintervention. Kaplan-Meier analysis was performed to assess reintervention-free survival. Results: A total of 42 patients with 62 rAMLs were included, with a mean age of 43.9 ± 12.2 years (range: 23–68). The majority were female (80.9%, n = 34), and 18.1% (n = 8) had TSC-associated rAML. TSC-associated cases presented at a younger age and had Table 2/Results give volume p=0.007, not 0.002 (0.002 is for size)., lower hemoglobin levels (p = 0.02), and higher creatinine levels (p = 0.05) compared to sporadic rAML cases. SAE achieved a 100% technical success rate. The mean hospitalization duration was 4.16 ± 4.04 days, and no major complications were observed. The mean follow-up period was 35.27 ± 37.67 months. During follow-up, 6 patients (14.3%) required reintervention, including 4 re-embolizations and 2 surgical procedures. The overall Kaplan-Meier estimate of freedom from reintervention at 4.6 years was 68%, with significantly higher reintervention rates in TSC-associated cases (p = 0.04). When comparing embolization techniques, optimal embolization (coils + polyvinyl alcohol [PVA] particles) resulted. This p-value (0.049) is a between-group baseline volume comparison not a volume-reduction. Can you please write ‘significantly greater baseline volume (p = 0.049). In contrast, non-optimal embolization (coils or PVA alone) p=0.059 is not significant at your stated α=0.05 — 'less significant' implies it is. Please write: 'did not reach statistical significance reduction in maximum lesion diameter (p = 0.059). Despite this, there was no significant difference in pre- and post-procedure laboratory parameters between the two embolization groups, except for lesion volume. Conclusions: SAE is effective for managing rAMLs, with high technical success and acceptable re-intervention rates. Optimal embolization plays a pivotal role in enhancing treatment efficacy.

Anahtar Kelimeler

Destekleyen Kurum

Ethics Committee of Ege University Faculty of Medicine

Proje Numarası

24-1T/22

Etik Beyan

Declarations Ethics Approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Ege University Faculty of Medicine (Date: 07.10.2024 Application no: 2024-3596; Decision No: 24-1T/22). Consent to Participate: The requirement for informed consent was waived by the Ethics Committee of Ege University Faculty of Medicine due to the retrospective nature of the study. Funding: The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

Kaynakça

  1. 1. Claesen E, Bonne L, Laenen A, Bammens B, Albersen M, De Wever L, et al. Safety, Efficacy, and Predictors for Late Reintervention After Embolization of Renal Angiomyolipomas - Embolization renal angiomyolipoma. Rofo. 2023;195(4):319–25.
  2. 2. Elek A, Kwon JW, Ertugrul S, Oren NC. Radiologic and pathologic correlation of a renal venous hemangioma. Int Cancer Conf J. 2023;12(4):227–32.
  3. 3. Nozadze G, Larsen SB, Heerwagen S, Juhl Jensen R, Lonn L, Roder MA. Selective arterial embolization of renal angiomyolipomas: A 10-year experience. BJUI Compass. 2022;3(1):86–92.
  4. 4. Northrup H, Aronow ME, Bebin EM, Bissler J, Darling TN, de Vries PJ, et al. Updated International Tuberous Sclerosis Complex Diagnostic Criteria and Surveillance and Management Recommendations. Pediatr Neurol. 2021;123:50–66.
  5. 5. Anis O, Rimon U, Ramon J, Khaitovich B, Zilberman DE, Portnoy O, et al. Selective Arterial Embolization for Large or Symptomatic Renal Angiomyolipoma: 10 Years of Follow-up. Urology. 2020;135:82–7.
  6. 6. Flum AS, Hamoui N, Said MA, Yang XJ, Casalino DD, McGuire BB, et al. Update on the Diagnosis and Management of Renal Angiomyolipoma. J Urol. 2016;195(4 Pt 1):834–46.
  7. 7. Sward J, Bohlin K, Henrikson O, Lundstam S, Peeker R, Grenabo Bergdahl A. Long-term efficacy of selective arterial embolisation of renal angiomyolipoma. Scand J Urol. 2023;58:86–92.
  8. 8. Park BK. Renal Angiomyolipoma: Radiologic Classification and Imaging Features According to the Amount of Fat. AJR Am J Roentgenol. 2017;209(4):826–35.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Radyoloji ve Organ Görüntüleme

Bölüm

Araştırma Makalesi

Yazarlar

Umut Deniz Pak
0009-0001-0400-3925
Türkiye

Yayımlanma Tarihi

3 Eylül 2026

Gönderilme Tarihi

16 Mayıs 2026

Kabul Tarihi

29 Haziran 2026

Yayımlandığı Sayı

Yıl 2026 Cilt: 65 Sayı: 3

DOI

https://doi.org/10.19161/etd.1890963

IZ

https://izlik.org/JA34NC74BU

Kaynak Göster

RIS / Bibtex
APA
Küsbeci, M., Elek, A., Kıran, F., Pak, U. D., Öztürk, E., Cinar, C., & Oran, İ. (2026). Selective arterial embolization for renal angiomyolipoma: The role of optimal embolization. Ege Tıp Dergisi, 65(3), 538-546. https://doi.org/10.19161/etd.1890963
AMA
1.Küsbeci M, Elek A, Kıran F, vd. Selective arterial embolization for renal angiomyolipoma: The role of optimal embolization. ETD. 2026;65(3):538-546. doi:10.19161/etd.1890963
Chicago
Küsbeci, Mahmut, Alperen Elek, Ferhat Kıran, vd. 2026. “Selective arterial embolization for renal angiomyolipoma: The role of optimal embolization”. Ege Tıp Dergisi 65 (3): 538-46. https://doi.org/10.19161/etd.1890963.
EndNote
Küsbeci M, Elek A, Kıran F, Pak UD, Öztürk E, Cinar C, Oran İ (01 Eylül 2026) Selective arterial embolization for renal angiomyolipoma: The role of optimal embolization. Ege Tıp Dergisi 65 3 538–546.
IEEE
[1]M. Küsbeci vd., “Selective arterial embolization for renal angiomyolipoma: The role of optimal embolization”, ETD, c. 65, sy 3, ss. 538–546, Eyl. 2026, doi: 10.19161/etd.1890963.
ISNAD
Küsbeci, Mahmut - Elek, Alperen - Kıran, Ferhat - Pak, Umut Deniz - Öztürk, Egemen - Cinar, Celal - Oran, İsmail. “Selective arterial embolization for renal angiomyolipoma: The role of optimal embolization”. Ege Tıp Dergisi 65/3 (01 Eylül 2026): 538-546. https://doi.org/10.19161/etd.1890963.
JAMA
1.Küsbeci M, Elek A, Kıran F, Pak UD, Öztürk E, Cinar C, Oran İ. Selective arterial embolization for renal angiomyolipoma: The role of optimal embolization. ETD. 2026;65:538–546.
MLA
Küsbeci, Mahmut, vd. “Selective arterial embolization for renal angiomyolipoma: The role of optimal embolization”. Ege Tıp Dergisi, c. 65, sy 3, Eylül 2026, ss. 538-46, doi:10.19161/etd.1890963.
Vancouver
1.Mahmut Küsbeci, Alperen Elek, Ferhat Kıran, Umut Deniz Pak, Egemen Öztürk, Celal Cinar, İsmail Oran. Selective arterial embolization for renal angiomyolipoma: The role of optimal embolization. ETD. 01 Eylül 2026;65(3):538-46. doi:10.19161/etd.1890963

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