Araştırma Makalesi

Functional, nutritional, and inflammatory predictors of survival in early-onset gastric cancer

Cilt: 65 Sayı: 3 3 Eylül 2026
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Functional, nutritional, and inflammatory predictors of survival in early-onset gastric cancer

Öz

Aim: Early-onset gastric cancer (EOGC) represents a distinct subgroup with aggressive clinicopathological features; however, prognostic data in younger patients remain limited. This study aimed to evaluate clinicopathological characteristics and identify prognostic factors associated with survival in patients aged ≤ 50 years with gastric cancer. Materials and Methods: A total of 60 patients aged ≤ 50 years diagnosed with gastric cancer between 2014 and 2024 were included in this retrospective single-center study. Survival outcomes were analyzed using the Kaplan–Meier method, and prognostic factors were evaluated with Cox proportional hazards regression analysis. Results: The median age was 40.9 years, and 51.7% of patients were female. Diffuse or signet-ring cell histology and advanced-stage disease were frequently observed. Median progression-free survival (PFS) and overall survival (OS) were 19.3 and 26.0 months, respectively. Signet-ring cell histology, low Prognostic Nutritional Index (PNI), and elevated platelet-to-lymphocyte ratio (PLR) were associated with shorter PFS. In univariate analysis, poor Eastern Cooperative Oncology Group (ECOG) performance status (PS), low PNI, advanced stage, and total gastrectomy were associated with inferior survival. In multivariate analysis, ECOG PS 3 and elevated PLR independently predicted mortality. Conclusions: EOGC commonly presents with advanced disease and unfavorable outcomes. Both tumor-related factors and host-related parameters—including functional status, nutritional condition, and systemic inflammatory markers—play an important role in determining prognosis and may improve risk stratification in younger patients.

Anahtar Kelimeler

Etik Beyan

Ethical approval for this study was obtained from the Adiyaman University Ethics Committee (October 14, 2025; approval number: 2025/8-1). Due to the retrospective nature of the study, the requirement for informed consent was waived. The study was conducted in accordance with the principles of the Declaration of Helsinki.

Teşekkür

“The authors would like to thank Mine Kaya for her support with statistical analysis.”

Kaynakça

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  3. 3. Isobe T, Hashimoto K, Kizaki J, et al. Characteristics and prognosis of gastric cancer in young patients. Oncol Rep. 2013;30(1):43-9.
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  5. 5. Qiu MZ, Cai MY, Zhang DS, et al. Clinicopathological characteristics and prognostic analysis of gastric cancer in young patients. Tumour Biol. 2011;32(3):509-14. doi:10.1007/s13277-010-0128-0
  6. 6. Liu S, Feng F, Xu G, et al. Clinicopathological features and prognosis of gastric cancer in young patients. BMC Cancer. 2016; 16:478.
  7. 7. Saito H, Takaya S, Fukumoto Y, et al. Clinicopathologic characteristics and prognosis of gastric cancer in young patients. Yonago Acta Med. 2012;55(3):57-61.
  8. 8. De B, Rhome R, Jairam V, et al. Gastric adenocarcinoma in young adult patients: patterns of care and survival in the United States. Gastric Cancer. 2018;21(6):889-99.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Onkoloji

Bölüm

Araştırma Makalesi

Yazarlar

Yayımlanma Tarihi

3 Eylül 2026

Gönderilme Tarihi

17 Mart 2026

Kabul Tarihi

24 Nisan 2026

Yayımlandığı Sayı

Yıl 2026 Cilt: 65 Sayı: 3

DOI

https://doi.org/10.19161/etd.1910511

IZ

https://izlik.org/JA65JU68XT

Kaynak Göster

RIS / Bibtex
APA
Uğuztemur, E., & Arıcı, M. Ö. (2026). Functional, nutritional, and inflammatory predictors of survival in early-onset gastric cancer. Ege Tıp Dergisi, 65(3), 441-452. https://doi.org/10.19161/etd.1910511
AMA
1.Uğuztemur E, Arıcı MÖ. Functional, nutritional, and inflammatory predictors of survival in early-onset gastric cancer. ETD. 2026;65(3):441-452. doi:10.19161/etd.1910511
Chicago
Uğuztemur, Esma, ve Mustafa Özgür Arıcı. 2026. “Functional, nutritional, and inflammatory predictors of survival in early-onset gastric cancer”. Ege Tıp Dergisi 65 (3): 441-52. https://doi.org/10.19161/etd.1910511.
EndNote
Uğuztemur E, Arıcı MÖ (01 Eylül 2026) Functional, nutritional, and inflammatory predictors of survival in early-onset gastric cancer. Ege Tıp Dergisi 65 3 441–452.
IEEE
[1]E. Uğuztemur ve M. Ö. Arıcı, “Functional, nutritional, and inflammatory predictors of survival in early-onset gastric cancer”, ETD, c. 65, sy 3, ss. 441–452, Eyl. 2026, doi: 10.19161/etd.1910511.
ISNAD
Uğuztemur, Esma - Arıcı, Mustafa Özgür. “Functional, nutritional, and inflammatory predictors of survival in early-onset gastric cancer”. Ege Tıp Dergisi 65/3 (01 Eylül 2026): 441-452. https://doi.org/10.19161/etd.1910511.
JAMA
1.Uğuztemur E, Arıcı MÖ. Functional, nutritional, and inflammatory predictors of survival in early-onset gastric cancer. ETD. 2026;65:441–452.
MLA
Uğuztemur, Esma, ve Mustafa Özgür Arıcı. “Functional, nutritional, and inflammatory predictors of survival in early-onset gastric cancer”. Ege Tıp Dergisi, c. 65, sy 3, Eylül 2026, ss. 441-52, doi:10.19161/etd.1910511.
Vancouver
1.Esma Uğuztemur, Mustafa Özgür Arıcı. Functional, nutritional, and inflammatory predictors of survival in early-onset gastric cancer. ETD. 01 Eylül 2026;65(3):441-52. doi:10.19161/etd.1910511

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