Diyabetik sıçan overlerindeki glikoz hasarı ve NF-kappa B yolunun etkisi

Pala H G; Erbaş O; Oltulu F; Pala E; Aktuğ H; Yavaşoğlu A

EN TR

Glucose injury in diabetic rats' ovaries and effect of NF-kappa B way

Abstract

Aim: To investigate glucose toxicity for ovarian damage severity and the effect of these by NF-kappa B way in rat models. Materials and Methods: An experimental diabetes mellitus model was created in seven rats. All seven rats, whose blood glucose levels were normal, were included in the control group. After eight weeks; bilateral oophorectomy was performed and the ovaries were researched histologically. The group characteristics were compared by one-way ANOVA and Mann Whitney U test. p values less than 0.05 were accepted as significant. Results: There was a significant increase of follicular degeneration, stromal degeneration, stromal fibrosis and NF-kappa B immune-expression in diabetic rats' ovary when compared to the control group of normal rats (p=0,0001). Conclusion: Our study shows that glucose toxicity occured severely in the ovaries and this injury originated in the NF-kappa B way in diabetes mellitus. Therefore, NF-kappa B inhibitors continue to be promising in preventing diabetic related tissue injury.

Keywords

Diabetes mellitus, premature ovarian failure, advanced glication end products, receptor of advanced glication end products, NF-kappa B.

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Pala H G

Erbaş O

Oltulu F

Pala E

Aktuğ H

Yavaşoğlu A

Yayımlanma Tarihi

1 Mart 2013

Gönderilme Tarihi

1 Mart 2013

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2013 Cilt: 52 Sayı: 1

IZ

https://izlik.org/JA86ZF88PX

Kaynak Göster

RIS / Bibtex

Vancouver

1.Pala H G, Erbaş O, Oltulu F, Pala E, Aktuğ H, Yavaşoğlu A. Diyabetik sıçan overlerindeki glikoz hasarı ve NF-kappa B yolunun etkisi. ETD [Internet]. 01 Mart 2013;52(1):32-6. Erişim adresi: https://izlik.org/JA86ZF88PX

Diyabetik sıçan overlerindeki glikoz hasarı ve NF-kappa B yolunun etkisi

Glucose injury in diabetic rats' ovaries and effect of NF-kappa B way

Abstract

Keywords