Glucose injury in diabetic rats' ovaries and effect of NF-kappa B way

Volume: 52 Number: 1 March 1, 2013
  • Pala H G
  • Erbaş O
  • Oltulu F
  • Pala E
  • Aktuğ H
  • Yavaşoğlu A
Ege Journal of Medicine Cover
Ege Journal of Medicine
PDF Download
EN TR

Glucose injury in diabetic rats' ovaries and effect of NF-kappa B way

Abstract

Aim: To investigate glucose toxicity for ovarian damage severity and the effect of these by NF-kappa B way in rat models. Materials and Methods: An experimental diabetes mellitus model was created in seven rats. All seven rats, whose blood glucose levels were normal, were included in the control group. After eight weeks; bilateral oophorectomy was performed and the ovaries were researched histologically. The group characteristics were compared by one-way ANOVA and Mann Whitney U test. p values less than 0.05 were accepted as significant. Results: There was a significant increase of follicular degeneration, stromal degeneration, stromal fibrosis and NF-kappa B immune-expression in diabetic rats' ovary when compared to the control group of normal rats (p=0,0001). Conclusion: Our study shows that glucose toxicity occured severely in the ovaries and this injury originated in the NF-kappa B way in diabetes mellitus. Therefore, NF-kappa B inhibitors continue to be promising in preventing diabetic related tissue injury.

Keywords

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Pala H G

Erbaş O

Oltulu F

Pala E

Aktuğ H

Yavaşoğlu A

Publication Date

March 1, 2013

Submission Date

March 1, 2013

Acceptance Date

-

Published in Issue

Year 2013 Volume: 52 Number: 1

IZ

https://izlik.org/JA86ZF88PX

Cite

RIS / Bibtex
Vancouver
1.Pala H G, Erbaş O, Oltulu F, Pala E, Aktuğ H, Yavaşoğlu A. Diyabetik sıçan overlerindeki glikoz hasarı ve NF-kappa B yolunun etkisi. EJM [Internet]. 2013 Mar. 1;52(1):32-6. Available from: https://izlik.org/JA86ZF88PX

Ege Journal of Medicine enables the sharing of articles according to the Attribution-Non-Commercial-Share Alike 4.0 International (CC BY-NC-SA 4.0) license.