Diyabetik sıçan overlerindeki glikoz hasarı ve NF-kappa B yolunun etkisi

Pala H G; Erbaş O; Oltulu F; Pala E; Aktuğ H; Yavaşoğlu A

EN TR

Glucose injury in diabetic rats' ovaries and effect of NF-kappa B way

Abstract

Aim: To investigate glucose toxicity for ovarian damage severity and the effect of these by NF-kappa B way in rat models. Materials and Methods: An experimental diabetes mellitus model was created in seven rats. All seven rats, whose blood glucose levels were normal, were included in the control group. After eight weeks; bilateral oophorectomy was performed and the ovaries were researched histologically. The group characteristics were compared by one-way ANOVA and Mann Whitney U test. p values less than 0.05 were accepted as significant. Results: There was a significant increase of follicular degeneration, stromal degeneration, stromal fibrosis and NF-kappa B immune-expression in diabetic rats' ovary when compared to the control group of normal rats (p=0,0001). Conclusion: Our study shows that glucose toxicity occured severely in the ovaries and this injury originated in the NF-kappa B way in diabetes mellitus. Therefore, NF-kappa B inhibitors continue to be promising in preventing diabetic related tissue injury.

Keywords

Diabetes mellitus, premature ovarian failure, advanced glication end products, receptor of advanced glication end products, NF-kappa B.

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Pala H G

Erbaş O

Oltulu F

Pala E

Aktuğ H

Yavaşoğlu A

Publication Date

March 1, 2013

Submission Date

March 1, 2013

Acceptance Date

-

Published in Issue

Year 2013 Volume: 52 Number: 1

IZ

https://izlik.org/JA86ZF88PX

Cite

RIS / Bibtex

APA

G, P. H., O, E., F, O., E, P., H, A., & A, Y. (2013). Diyabetik sıçan overlerindeki glikoz hasarı ve NF-kappa B yolunun etkisi. Ege Tıp Dergisi, 52(1), 32-36. https://izlik.org/JA86ZF88PX

AMA

1.G PH, O E, F O, E P, H A, A Y. Diyabetik sıçan overlerindeki glikoz hasarı ve NF-kappa B yolunun etkisi. EJM. 2013;52(1):32-36. https://izlik.org/JA86ZF88PX

Chicago

G, Pala H, Erbaş O, Oltulu F, Pala E, Aktuğ H, and Yavaşoğlu A. 2013. “Diyabetik Sıçan Overlerindeki Glikoz Hasarı Ve NF-Kappa B Yolunun Etkisi”. Ege Tıp Dergisi 52 (1): 32-36. https://izlik.org/JA86ZF88PX.

EndNote

G PH, O E, F O, E P, H A, A Y (March 1, 2013) Diyabetik sıçan overlerindeki glikoz hasarı ve NF-kappa B yolunun etkisi. Ege Tıp Dergisi 52 1 32–36.

IEEE

[1]P. H. G, E. O, O. F, P. E, A. H, and Y. A, “Diyabetik sıçan overlerindeki glikoz hasarı ve NF-kappa B yolunun etkisi”, EJM, vol. 52, no. 1, pp. 32–36, Mar. 2013, [Online]. Available: https://izlik.org/JA86ZF88PX

ISNAD

G, Pala H - O, Erbaş - F, Oltulu - E, Pala - H, Aktuğ - A, Yavaşoğlu. “Diyabetik Sıçan Overlerindeki Glikoz Hasarı Ve NF-Kappa B Yolunun Etkisi”. Ege Tıp Dergisi 52/1 (March 1, 2013): 32-36. https://izlik.org/JA86ZF88PX.

JAMA

1.G PH, O E, F O, E P, H A, A Y. Diyabetik sıçan overlerindeki glikoz hasarı ve NF-kappa B yolunun etkisi. EJM. 2013;52:32–36.

MLA

G, Pala H, et al. “Diyabetik Sıçan Overlerindeki Glikoz Hasarı Ve NF-Kappa B Yolunun Etkisi”. Ege Tıp Dergisi, vol. 52, no. 1, Mar. 2013, pp. 32-36, https://izlik.org/JA86ZF88PX.

Vancouver

1.Pala H G, Erbaş O, Oltulu F, Pala E, Aktuğ H, Yavaşoğlu A. Diyabetik sıçan overlerindeki glikoz hasarı ve NF-kappa B yolunun etkisi. EJM [Internet]. 2013 Mar. 1;52(1):32-6. Available from: https://izlik.org/JA86ZF88PX