LOKAL İLERİ EVRE SERVİKS KANSERİ TANISI İLE RADYOKEMOTERAPİ UYGULANAN OLGULARDA ERKEN SONUÇLAR

Cilt: 41 Sayı: 3 1 Eylül 2002
  • Zeynep Özsaran
  • Deniz Yalman
  • Vuslat Yürüt
  • Arif Araş
  • Aydın ÖZS AR An
  • Merih Hanhan
  • Ayfer Haydaroğlu
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RADIOCHEMOTHERAPY FOR PATIENTS WITH LOCALLY ADVANCED CERVICAL CANCER: EARLY RESULTS

Abstract

Radiotherapy is the standart treatment of locally advanced cervıcal cancer. Recent results of the prospective randomized trials showed an overall survival and local control advantage for cisplatin based therapy given concurrently with radiation therapy. Thirty-nine patients who received concurrent chemoradiation between October 1999 and December 2000 were evaluated for treatment response, local control and toxicity. Thirty-nine patients with stage IB-IVA cervıcal carcinoma received weekly cisplatin 40 mg/m2 concurrent with radiotherapy. Median cisplatin administration was 5 weeks. Thirty-two patients received both external and intracavitary radiotherapy and seven patients received only external radiotherapy because of insufficient tumor response for intracavitary apllication. Total external radiotherapy dose was 64.8 Gy with 1.8 Gy daily fractions in patients who received only external radiotherapy. Midline shielding was performed at 50.4 Gy in patients who were going to receive brachytherapy and the total external radiotherapy dose was 54-59.4 Gy. Brachytherapy was performed with Rotterdam applicator via microSelectron HDR machine. A total dose of 8.5-18 Gy was applied to pointA. Median age was 55. Distribution by stages according to FIGO staging system were as follows: stage IB 5.1%, HA 28.2%, IIB 43.6%, IHA 7.7%, IHB 12.8% and IVA 2.6%. Histologically 33 (84.6%) were epidermoid carcinoma, 1 was adenocarcînoma, 2 were indiffrentiated carcinoma, 1 was malignant epithelial tumor. İn two patients histological subtype could not be specified. The median duration of follow-up was 20 months. Four patients (10.3%) had local recurrence and three developed distant metastases being two lung and one bone metastases. Thirty patients (76.9%) had complete response, 8 had (20.5%) partial response and one had (2.6%) stable disease. During or after radiochemotherapy 46.2% of the patients developed toxicity due to chemotherapy, Early and late radiation morbidity rates were 66.7% and 71.8% respectively. No grade IH-IV toxicity was observed. Concurrent chemoradiation for locally advanced cervıcal cancer is the treatment of choice in suitable patients providing high response rates with acceptable toxicity.

Keywords

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Zeynep Özsaran

Deniz Yalman

Vuslat Yürüt

Arif Araş

Aydın ÖZS AR An

Merih Hanhan

Ayfer Haydaroğlu

Yayımlanma Tarihi

1 Eylül 2002

Gönderilme Tarihi

1 Eylül 2002

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2002 Cilt: 41 Sayı: 3

IZ

https://izlik.org/JA55EF47DD

Kaynak Göster

RIS / Bibtex
Vancouver
1.Zeynep Özsaran, Deniz Yalman, Vuslat Yürüt, Arif Araş, Aydın ÖZS AR An, Merih Hanhan, Ayfer Haydaroğlu. LOKAL İLERİ EVRE SERVİKS KANSERİ TANISI İLE RADYOKEMOTERAPİ UYGULANAN OLGULARDA ERKEN SONUÇLAR. ETD [Internet]. 01 Eylül 2002;41(3):157-62. Erişim adresi: https://izlik.org/JA55EF47DD

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