Changes in ghrelin, leptin and ınsulin levels after laparoscopic sleeve gastrectomy

Varlık Erol; Cengiz Aydın; Levent Uğurlu; Emre Turgut; Hülya Yalçın; Fatma Demet Arslan

doi:10.19161/etd.418130

TR EN

Laparoskopik sleeve gastrektomi sonrası grelin, leptin ve insülin düzeylerindeki değişiklikler

Öz

Amaç: Bu çalışmada, morbid obezite tanılı hastalarda tedavi amacıyla uygulanan LSG’nin kilo kaybı ve yandaş hastalıkların tedavisinin yanı sıra metabolik ve hormonal mekanizmalar üzerindeki etkinliğinin, operasyon öncesi ve operasyon sonrası dönemdeki hormon düzeyleri karşılaştırılarak irdelenmesi amaçlandı.

Gereç ve Yöntemler: Mayıs 2013-Mayıs 2014 tarihleri arasında, LSG uygulanan 38 hasta çalışmaya dahil edildi. Prospektif olan bu çalışmada hastaların demografik verileri, yandaş hastalıkları, takipte kilo kaybı, morbidite ve mortalite oranları, operasyon öncesi ve sonrası insülin düzeyleri ile operasyon öncesi ve operasyon sonrası sekizinci haftadaki leptin ve grelin hormonlarının düzeyleri irdelenerek karşılaştırıldı.

Bulgular: Çalışmaya dahil edilen 38 hastadan 32’si (%84.2) kadın, altısı (%15.8) ise erkekti. Operasyon öncesi alınan kandaki leptin düzeylerinin ortalaması 11.16 ng/mL iken, operasyon sonrası sekizinci haftadaki hormon seviyesi 4.39 ng/mL olarak belirlendi. Grelin düzeylerine bakıldığında ise; operasyon öncesi ortalama 25.72 pg/mL iken, operasyon sonrası sekizinci haftadaki hormon seviyesi 14.16 pg/mL olarak belirlendi. Operasyon öncesi ortalama vücut kitle indeksi (VKİ) 44.3, operasyon sonrası sekizinci haftada ise 36.6 olarak belirlendi. Hiçbir hastada mortalite gerçekleşmedi.

Sonuç: LSG, günümüzde mükemmel kilo kaybı sağlaması ve kabul edilebilir oranlarda düşük komplikasyon riskleri nedeniyle morbid obezite tedavisinde tek başına uygulanan bir cerrahi teknik haline gelmiştir. Çalışmamızın sonuçlarına baktığımız zaman; bu ameliyat tekniğinin sadece restriktif değil, aynı zamanda metabolik değişikliklere neden olarak da kilo kaybındaki devamlılığı sağladığı kanaatindeyiz.

Anahtar Kelimeler

Morbid obezite,sleeve gastrektomi,hormonal değişiklikler.

Changes in ghrelin, leptin and ınsulin levels after laparoscopic sleeve gastrectomy

Abstract

Aim: The objective of this study was to evaluate the effects of laparoscopic sleeve gastrectomy (LSG), performed upon patients with morbid obesity, on weight loss and recovery of comorbid diseases as well as on metabolic and hormonal mechanisms by comparing pre and postoperative hormone levels.

Materials and Methods: 38 patients having undergone LSG between May 2013 and May 2014 were included in the study. In this prospective study, patients’ demographic data and associated diseases; weight loss; pre and post-operative insulin levels in addition to pre and post-operative leptin and ghrelin levels in the eighth weeks were compared.

Results: Of 38 patients included in the study there were 32 (84.2%) females and 6 (15.8%) males. Median leptin level was 11.16 ng/mL in the preoperative blood sample, whereas postoperative hormone level in the eighth week was 4.39 ng/mL. When ghrelin levels were examined; preoperative median was 25.72 pg/mL, whereas postoperative hormone level was 14.16 pg/mL in the eighth week. Preoperative median body mass index was determined to be 44.27 and post-operative median was observed to be 36.6 in the eighth week. No mortality was observed.

Conclusion: Today LSG has become a unique surgical technique in the treatment of morbid obesity due to its efficiency in obtaining weight loss and its feasible complication rates. After reviewing the results of our study; we believe this surgical technique does not only provide continuity in weight loss by restrictive changes but at the same time by metabolic ones, too.

Keywords

Morbid obesity,sleeve gastrectomy,hormonal changes.

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Varlık Erol ^*
0000-0002-7337-4973
Türkiye

Cengiz Aydın
0000-0003-4713-2871
Türkiye

Levent Uğurlu
0000-0002-9415-2974
Türkiye

Emre Turgut
0000-0001-8196-1871
Türkiye

Hülya Yalçın
0000-0001-5224-8372
Türkiye

Fatma Demet Arslan
0000-0003-0766-0303
Türkiye

Yayımlanma Tarihi

14 Mart 2019

Gönderilme Tarihi

23 Ocak 2018

Kabul Tarihi

20 Şubat 2018

Yayımlandığı Sayı

Yıl 2019 Cilt: 58 Sayı: 1

DOI

https://doi.org/10.19161/etd.418130

IZ

https://izlik.org/JA68UN89CN

Kaynak Göster

RIS / Bibtex

Vancouver

1.Varlık Erol, Cengiz Aydın, Levent Uğurlu, Emre Turgut, Hülya Yalçın, Fatma Demet Arslan. Changes in ghrelin, leptin and ınsulin levels after laparoscopic sleeve gastrectomy. ETD. 01 Mart 2019;58(1):21-6. doi:10.19161/etd.418130

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