Mikrobiyom ve mikrobiyota

Behice Kurtaran

doi:10.19161/etd.863679

TR EN

Mikrobiyom ve mikrobiyota

Öz

Mikrobiyom ve mikrobiyota sıklıkla birbirlerinin yerine kullanılan ve insan vücudunda bulunan kommensal, simbiyotik ve patojenik mikroorganizmaların topluluğuna verilen isimdir. İnsan vücudunda mikroorganizmalar gastrointestinal sistem, orofaringeal alan, deri, hava yolları, ürogenital sistem, kan ve gözlerde lokalize olmuştur. Gastrointestinal mikrobiyomun koruyucu, metabolik ve yapısal etkileri söz konusudur. İntestinal mikrobiyota dengesi, immün regülasyonu sağlayan mikrobiyal kompozisyonun dengede kalması ile yani simbiyoz ile sağlanır. Eğer mikrobiyota çeşitliliğinde azalma, değişiklik ya da bozulma olursa –ki bu disbiyoz olarak adlandırılır- alerji ve inflamasyonla giden immün disregülasyon meydana gelir. Yani insan sağlığının idamesinde gastrointestinal mikrobiyotanın klinik önemi büyüktür. Kardiyovasküler hastalık, obesite, tip 2 diyabet, non-alkolik yağlı karaciğer hastalığı (NAFLD) ve bazı kanser tipleri ile disbiyoz arasında ilişki olduğunu gösteren çalışmalar mevcuttur.

Anahtar Kelimeler

Kaynakça

Lederberg J, McCray AT. Genealogical Treasury of Words. Scientist 2001; 15 (7): 8.
Kamada N, Seo SU, Chen GY, Nunez G. Role of the gut microbiota in immunity and inflammatory disease. Nat. Rev. Immunol 2013; 13: 321-35. 10.1038/nri3430.
Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature 2010; 464: 59-65. 10.1038/nature08821
Hansen TH, Gobel RJ, Hansen T, Pedersen O. The gut microbiome in cardio-metabolic health. Genome Med 2015; 7 (1): 33. doi: 10.1186/s13073-015-0157-z.
Kamo T, Akazawa H, Suda W, et al. Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure. PLoS One 2017; 12 (3): e0174099. 10.1371
Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature 2006; 444: 1022-3. 10.1038/4441022a
Wang Z, Klipfell E, Bennett BJ, et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 2011; 472: 57-63. 10.1038/nature09922
Sommer F, Backhed F. The gut microbiota-masters of host development and phisiology. Nature Rev Microbiol 2013;11(4):227-38.

Pedersen HK, Gudmundsdottir V, Nielsen HB, et al. Human gut microbes impact host serum metabolome and insulin sensitivity. Nature 2016; 535: 376-81. 10.1038/nature18646
Henao-Mejia J, Elinav E, Jin C, et al. Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 2012;482:179-85. 10.1038/nature10809
Tang WH, Kitai T, Hazen SL. Gut microbiota in cardiovascular health and disease. Circ Res 2017;120:1183-96. 10.1161/circresaha.117.309715
Emoto T, Yamashita T, Kobayashi T, et al. Characterization of gut microbiota profiles in coronary artery disease patients using data mining analysis of terminal restriction fragment length polymorphism: gut microbiota could be a diagnostic marker of coronary artery disease. Heart Vessels 2017; 32: 39-46. 10.1007/s00380-016-0841-y
Cani PD, Bibiloni R, Knauf C, et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes Metab Res Rev 2008;57:1470-81. 10.2337/db07-1403
Khan MT, Nieuwdorp M, Backhed F. Microbial modulation of insulin sensitivity. Cell Metab 2014;20:753-60. 10.1016/j.cmet.2014.07.006
Mouzaki M, Comelli EM, Arendt BM, et al. Intestinal microbiota in patients with nonalcoholic fatty liver disease. Hepatology 2013; 58: 120-27. 10.1002/hep.26319
Zhu L, Baker SS, Gill C, et al. Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH. Hepatology 2013; 57: 601-9. 10.1002/hep.26093
Gopalakrishnan V, Helmink BA, Spencer CN, Reuben A, Wargo JA. The influence of the gut microbiome on cancer, immunity, and cancer immunotherapy. Cancer Cell 2018; 33: 570-80. 10.1016/j.ccell.2018.03.015
Tilg H, Adolph TE, Gerner RR, Moschen AR. The intestinal microbiota in colorectal cancer. Cancer Cell 2018; 33: 954-64. 10.1016/j.ccell.2018.03.004
Mullié C, Yazourh A, Thibault H, et al. Increased poliovirus-specific intestinal antibody response coincides with promotion of Bifidobacterium longum-infantis and Bifidobacterium brevein infants: a randomized, double-blind, placebo-controlled trial. Pediatr Res 2004; 56: 791-5.
Thibault H, Aubert Jacquin C, Goulet O. Effects of long-term consumption of a fermented ınfant formula (with Bifidobacterium breve c50 and Streptococcus thermophilus 065) on acute diarrhea in healthy ınfants. Journal of Pediatric Gastroenterology and Nutrition 39 (2): 147-52.
Anabrees J, Indrio F, Paes B, AlFaleh K. Probiotics for infantil colic: a systematic review. BMC Pediatr 2013; 13: 186. 1186/1471-2431-13-186.
Campeotto F, Suau A, Kapel N, et al. A fermented formula in pre-term infants: clinical tolerance, gut microbiota, down-regulation of faecal calprotectin and up-regulation of faecal secretory IgA. Br J Nutr 2011; 28; 105 (12): 1843-51.
Morisset M, Aubert-Jacquin C, Soulaines P, Moneret-Vautrin DA, Dupont C. A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy. Eur J Clin Nutr 2011; 65 (2): 175-83.
Van de Heijning BJ, Berton A, Bouritius H, Goulet O. GI Symptoms in ınfants are a potential target for fermented ınfant milk formulae: a review. Nutrients 2014; 6 (9): 3942-67.
Kronman MP, Zaoutis TE, Haynes K, Feng R, Coffin SE. Antibiotic exposure and ibd development among children: a population-based cohort study. Pediatrics 2012; 130 (4): e794-e803.
Maeda, Yuichi, and Kiyoshi Takeda. “Role of Gut Microbiota in Rheumatoid Arthritis.” Journal of clinical medicine vol. 6,6 60. 9 Jun. 2017, doi:10.3390/jcm6060060
Yuichi Maeda, Kiyoshi Takeda Host–microbiota interactions in rheumatoid arthritis. Experimental and Molecular Medicine volume 51, pages1–6(2019)
Chermesh Eliakim R. Probiotics and the gastrointestinal tract: Where are we in 2005? World J Gastroenterol 2006; 12: 853-7.
Report of a Joint FAO/WHO Expert Consultation on Evaluation of Health and nutrional properties of probiotics in food including powder milk with live lactic acid bacteria. Argentina 1-4 October 2001.
Gupta S, Allen-Vercoe E, Petrof EO. Fecal microbiota transplantation: in perspective. Therap Adv Gastroenterol. 2016; 9 (2): 229-239. doi:10.1177/1756283X15607414

Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Olgu Sunumu

Yazarlar

Behice Kurtaran ^*
0000-0002-2081-4664
Türkiye

Yayımlanma Tarihi

20 Ocak 2021

Gönderilme Tarihi

6 Nisan 2020

Kabul Tarihi

28 Ağustos 2020

Yayımlandığı Sayı

Yıl 2021

DOI

https://doi.org/10.19161/etd.863679

IZ

https://izlik.org/JA63NW32GN

Kaynak Göster

RIS / Bibtex

Vancouver

1.Behice Kurtaran. Mikrobiyom ve mikrobiyota. ETD. 01 Ocak 2021;88-93. doi:10.19161/etd.863679

Mikrobiyom ve mikrobiyota

Mikrobiyom ve mikrobiyota

Öz

Anahtar Kelimeler

Microbiome and microbiota

Abstract

Keywords

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster

Cited By

Besin Alerjileri ve Mikrobiyota

Bağırsak ve Akciğer Mikrobiyotaları Arasındaki İlişki

Üniversite Öğrencilerinin Mikrobiyota Farkındalık Düzeylerinin Değerlendirilmesi: Erzurum İli Örneği

An analysis of YouTube content about psychobiotics: Is the food and mood bond getting stronger?

Parkinson Hastalığı ve Mikrobiyota