Hashimoto
ensefalopatisi anti-tiroid otoantikorlarla ilişkili otoimmün etiyolojiye sahip
olduğu düşünülen bir hastalıktır. Klinik tablo akut ya da sinsi olarak
başlayabilir. Hastalık tanısı, klinik bulgular varlığında, serumda antitiroid
otoantikorların yüksek bulunması ve ensefalopatiye neden olabilecek diğer
nedenlerin ekarte edilmesiyle konur. Bu yazıda, akut nörolojik defisit ile
başvuran ve Hashimoto ensefalopatisi tanısı almış iki olgu sunulmaktadır.
De Holanda NC, de Lima DD, Cavalcanti TB, Lucena CS, Bandeira F. Hashimoto’s encephalopathy: Systematic review of the literarute and an additional case. J Neuropsychiatry Clin Neurosci 2011;23(4):384-90.
Salazar R, Mehta C, Zaher N, Miller D. Opsoclonus as a manifestation of Hashimoto's encephalopathy. Clin Neurosci 2012;19(10):1465-6.
Lee MJ, Lee HS, Hwang JS, Jung DE. A case of Hashimoto's encephalopathy presenting with seizures and psychosis. Korean J Pediatr 2012;55(3):111-3.
Castillo P, Woodruff B, Caselli R, et al. Steroid-responsive encephalopathy associated with autoimmune thyroiditis. Arch Neurol 2006;63(2):197-202
Hashimoto’s
encephalopathy is a disease considered to derive from an autoimmune etiology,
associated with anti-thyroid auto-antibodies. Clinical manifestations may
include acute or latent conditions. The disease is diagnosed through clinical
manifestations, high anti-thyroid auto-antibodies and elimination of other
conditions that may also cause encephalopathy. In this report, we present two
patients admitted with acute neurological deterioration and diagnosed with
Hashimoto’s encephalopathy.
De Holanda NC, de Lima DD, Cavalcanti TB, Lucena CS, Bandeira F. Hashimoto’s encephalopathy: Systematic review of the literarute and an additional case. J Neuropsychiatry Clin Neurosci 2011;23(4):384-90.
Salazar R, Mehta C, Zaher N, Miller D. Opsoclonus as a manifestation of Hashimoto's encephalopathy. Clin Neurosci 2012;19(10):1465-6.
Lee MJ, Lee HS, Hwang JS, Jung DE. A case of Hashimoto's encephalopathy presenting with seizures and psychosis. Korean J Pediatr 2012;55(3):111-3.
Castillo P, Woodruff B, Caselli R, et al. Steroid-responsive encephalopathy associated with autoimmune thyroiditis. Arch Neurol 2006;63(2):197-202
Muazzez Gökçen Karahan
Bakırköy Prof Dr. Mazhar Osman Mental and Neurological Disorders Education and Research Hospital, Clinic of Neurology, İstanbu0000-0001-5760-9077Türkiye
Yavuz Altunkaynak
Bakırköy Prof Dr. Mazhar Osman Mental and Neurological Disorders Education and Research Hospital, Clinic of Neurology, İstanbu0000-0002-4921-1592Türkiye
Alper Döventaş
İstanbul University Cerrahpaşa Faculty of Medicine, Department of Geriatrics, İstanbul0000-0001-5509-2625Türkiye
Sevim Baybaş
Bakırköy Prof Dr. Mazhar Osman Mental and Neurological Disorders Education and Research Hospital, Clinic of Neurology, İstanbul0000-0003-1724-9577Türkiye