Varfarin tedavisinde nadiren gözlenen yan etki: Deri nekrozu
Öz
Varfarin yaygın olarak tromboembolik hastalıkların önlenmesinde ve tedavisinde kullanılmaktadır. Bununla birlikte varfarin kullanımının, istenmeyen şekilde, varfarin kaynaklı cilt nekrozunun (WISN) da dahil olduğu aşırı-pıhtılaşma koşullarına neden olduğu bilinmektedir. Bu olgu sunumunda, sol kalp yetmezliği sonucu gelişen femoral ven trombozunun tedavisi sebebiyle hastanede yatan ve WISN gözlenen 70 yaşındaki bir erkek hasta tanımlamaktadır. Hastanın öyküsünde ayrıca kolon adenokarsinomu ve karaciğerde çoklu metastatik odaklar bildirilmiştir.
Anahtar Kelimeler
Kaynakça
- Nazarian RM, Van Cott EM, Zembowicz A, Duncan LM. Warfarin-induced skin necrosis. J Am Acad Dermatol 2009;61(2):325-32.
- Kakagia DD, Papanas N, Karadimas E, Polychronidis A. Warfarin-induced skin necrosis. Ann Dermatol 2014;26(1):96-8.
- Menon N, Sarode R, Zia A. Rivaroxaban dose adjustment using thrombin generation in severe congenital protein C deficiency and warfarin-induced skin necrosis. Blood Adv 2018;2(2):142-5.
- Chan YC, Valenti D, Mansfield AO, Stansby G. Warfarin induced skin necrosis. Br J Surg 2000;87(3):266-272.
- Hasegawa H. Clinical assessment of warfarin therapy in patients with maintenance dialysis-clinical efficacy, risks and development of calciphylaxis. Ann Vasc Dis 2017;10(3):170-7.
- Hamada T, Miyake T, Otsuka M, Iwatsuki K. Warfarin-induced skin necrosis accompanied by aggravation of vasculitis in a patient with cutaneous arteritis. Int J Dermatol 2017;56(7):779-81.
Skin necrosis: An uncommon side effect of warfarin therapy
Öz
Warfarin
is commonly used in the treatment and prevention of thromboembolic events.
However, it is known to undesirably cause hypercoagulable conditions, including
warfarin-induced skin necrosis (WISN). This report describes a 70-year-old man presented with an
extensive WISN while an inpatient for treatment of a left deep femoral
vein thrombosis. He had a background
of colon adenocarcinoma and multiple metastatic foci in the liver.
Anahtar Kelimeler
Warfarin skin necrosis anticoagulants therapeutic complication.
Kaynakça
- Nazarian RM, Van Cott EM, Zembowicz A, Duncan LM. Warfarin-induced skin necrosis. J Am Acad Dermatol 2009;61(2):325-32.
- Kakagia DD, Papanas N, Karadimas E, Polychronidis A. Warfarin-induced skin necrosis. Ann Dermatol 2014;26(1):96-8.
- Menon N, Sarode R, Zia A. Rivaroxaban dose adjustment using thrombin generation in severe congenital protein C deficiency and warfarin-induced skin necrosis. Blood Adv 2018;2(2):142-5.
- Chan YC, Valenti D, Mansfield AO, Stansby G. Warfarin induced skin necrosis. Br J Surg 2000;87(3):266-272.
- Hasegawa H. Clinical assessment of warfarin therapy in patients with maintenance dialysis-clinical efficacy, risks and development of calciphylaxis. Ann Vasc Dis 2017;10(3):170-7.
- Hamada T, Miyake T, Otsuka M, Iwatsuki K. Warfarin-induced skin necrosis accompanied by aggravation of vasculitis in a patient with cutaneous arteritis. Int J Dermatol 2017;56(7):779-81.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 28 Haziran 2019 |
| Gönderilme Tarihi | 31 Ocak 2018 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 58 Sayı: 2 |
