Restless leg syndrome in multiple sclerosis: relationship with restless legs syndrome and fatigue, quality of life, daytime sleepiness, sleep quality and anxiety-depression
Öz
Aim: This study aimed to explore the association between Restless Legs Syndrome (RLS) severity and fatigue, quality of life, daytime sleepiness, sleep quality, and levels of anxiety and depression in people with multiple sclerosis (MS, pwMS).
Materials and Methods: A total of 73 pwMS were recruited from the MS clinic at Van Yüzüncü Yıl University. RLS was diagnosed based on the International RLS Study Group. Various scales were used to assess sleep quality, fatigue, daytime sleepiness, quality of life, and depression and anxiety, including the Pittsburgh Sleep Quality Index (PSQI), Modified Fatigue Impact Scale (MFIS), Epworth Sleepiness Scale (ESS), Preference-Based Multiple Sclerosis Index (PBMSI), and the Hospital Anxiety and Depression Scale (HADS).
Results: RLS was identified in 20 participants (27.40%). Significant differences were observed between pwMS with and without RLS in terms of subjective sleep quality, sleep disturbances, daytime dysfunction, sleep latency and habitual sleep efficiency sub-scores of the PSQI, total PSQI score, physical, cognitive, and total fatigue scores (p<0.05). RLS severity showed a moderate positive correlation with MFIS-physical (r=0.535), MFIS-total (r=0.494), and PSQI-total scores (r=0.492).
Conclusion: This study sheds light on the relationships between RLS severity and factors such as sleep quality and fatigue in pwMS.
Anahtar Kelimeler
Multiple sclerosis Restless leg syndrome Sleep disorders Quality of life
Kaynakça
- Hunter SF. Overview and diagnosis of multiple sclerosis. Am J Manag Care. 2016 Jun;22(6 Suppl):s141-50.
- Öztürk B, Taşkıran E, Demir S, Tuncer MA, Kürtüncü M, Karabudak R, et al. Prevalence and incidence of multiple sclerosis in Turkey: A nationwide epidemiologic study. Multiple Sclerosis Journal. 2024 Jun 14;30(7):790–9.
- Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, et al. Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition. Multiple Sclerosis Journal. 2020 Dec 11;26(14):1816–21.
- Ozdogar AT, Kalron A. Restless legs syndrome in people with multiple sclerosis: An updated systematic review and meta-analyses. Mult Scler Relat Disord. 2021 Nov;56:103275.
- Deriu M, Cossu G, Molari A, Murgia D, Mereu A, Ferrigno P, et al. Restless legs syndrome in multiple sclerosis: A case‐control study. Movement Disorders. 2009 Apr 15;24(5):697–701.
- Manconi M, Rocca MA, Ferini-Strambi L, Tortorella P, Agosta F, Comi G, et al. Restless legs syndrome is a common finding in multiple sclerosis and correlates with cervical cord damage. Multiple Sclerosis Journal. 2008 Jan 1;14(1):86–93.
- Douay X, Waucquier N, Hautecoeur P, Vermersch P. Prévalence élevée du syndrome des jambes sans repos dans la sclérose en plaques. Rev Neurol (Paris). 2009 Feb;165(2):194–6.
- Italian REMS Study Group, Manconi M, Ferini-Strambi L, Filippi M, Bonanni E, Iudice A, et al. Multicenter case-control study on restless legs syndrome in multiple sclerosis: the REMS study. Sleep. 2008 Jul;31(7):944–52.
- Vávrová J, Kemlink D, Šonka K, Havrdová E, Horáková D, Pardini B, et al. Restless legs syndrome in Czech patients with multiple sclerosis: An epidemiological and genetic study. Sleep Med. 2012 Aug;13(7):848–51.
- Časar Rovazdi M. Restless Legs Syndrome In Multiple Sclerosis Patients – Patient Experience Atlipik Special Hospital For Medical Rehabilitation. Acta Clin Croat. 2017;80–3.
- Seferoğlu M, Sivaci AÖ, Tunç A. Restless legs syndrome/Willis-Ekbom disease in multiple sclerosis: a contributing factor for anxiety, disability, sleep disorder, and quality of life. Arq Neuropsiquiatr. 2020 Nov;78(11):708–12.
- Cederberg KLJ, Jeng B, Sasaki JE, Braley TJ, Walters AS, Motl RW. Restless legs syndrome and health-related quality of life in adults with multiple sclerosis. J Sleep Res. 2020;29(3):e12880.
- Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983 Nov;33(11):1444–52.
- Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance. Sleep Med. 2014 Aug;15(8):860–73.
- AY E, HELVACI YILMAZ N, ARICI DÜZ Ö, ÖZER FF. Validity and Reliability of the Turkish Version of The International Restless Legs Syndrome Study Group Rating Scale. Acta Medica Alanya. 2019 Aug 23;3(2):105–10.
- Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med. 2003 Mar;4(2):121–32.
- Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991 Dec;14(6):540–5.
- Izci B, Ardic S, Firat H, Sahin A, Altinors M, Karacan I. Reliability and validity studies of the Turkish version of the Epworth Sleepiness Scale. Sleep and Breathing. 2008 May 6;12(2):161–8.
- Armutlu K, Keser I, Korkmaz N, Akbiyik DI, Sümbüloğlu V, Güney Z, et al. Psychometric study of Turkish version of Fatigue Impact Scale in multiple sclerosis patients. J Neurol Sci. 2007 Apr 15;255(1–2):64–8.
- Ağargün MY, Kara H, Anlar O. Pittsburgh uyku kalitesi indeksinin geçerliği ve güvenirliği. Türk Psikiyatri Dergisi. 1996;107–15.
- Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Res. 1989 May;28(2):193–213.
- Pais Ribeiro JL, Martins da Silva A, Vilhena E, Moreira I, Santos E, Mendonça D. The hospital anxiety and depression scale, in patients with multiple sclerosis. Neuropsychiatr Dis Treat. 2018 Nov;Volume 14:3193–7.
- Aydemir O. Validity and Reliability of Turkish Version of Hospital Anxiety and Depression Scale [Internet]. Available from: https://www.researchgate.net/publication/284678404
- Kuspinar A, Mayo NE. Validation of the preference-based multiple sclerosis index. Multiple Sclerosis Journal. 2019 Oct 2;25(11):1496–505.
- Kahraman T, Özdoğar AT, Honan CA, Ertekin Ö, Özakbaş S. The multiple sclerosis work difficulties questionnaire: translation and cross-cultural adaptation to Turkish and assessment of validity and reliability. Disabil Rehabil. 2019 Oct 9;41(21):2556–62.
- Kilic S. Effect size. Journal of Mood Disorders. 2014;4(1):44.
- Akoglu H. User’s guide to correlation coefficients. Turk J Emerg Med. 2018 Sep;18(3):91–3.
- Jones KH, Ford D V., Jones PA, John A, Middleton RM, Lockhart-Jones H, et al. A Large-Scale Study of Anxiety and Depression in People with Multiple Sclerosis: A Survey via the Web Portal of the UK MS Register. PLoS One. 2012 Jul 30;7(7):e41910.
- Cederberg KLJ, Jeng B, Sasaki JE, Motl RW. Restless legs syndrome, sleep quality, and perceived cognitive impairment in adults with multiple sclerosis. Mult Scler Relat Disord. 2020 Aug;43:102176.
Multipl sklerozda huzursuz bacak sendromu: huzursuz bacak sendromu ile yorgunluk, yaşam kalitesi, gündüz uykululuğu, uyku kalitesi ve anksiyete-depresyon arasındaki ilişki
Öz
Amaç: Bu çalışma, multipl skleroz’lu (MS) bireylerde huzursuz bacaklar sendromu (HBS) şiddeti ile yorgunluk, yaşam kalitesi, gündüz uykululuk, uyku kalitesi, and anksiyete-depresyon seviyeleri arasındaki ilişkiyi incelemeyi amaçlamaktadır.
Gereç ve Yöntem: Van Yüzüncü Yıl Üniversitesi MS kliniğinden toplam 73 MS'li birey çalışmaya dahil edildi. HBS tanısı, Uluslararası HBS Çalışma Grubu tarafından belirlenen kriterler esas alınarak konuldu. Uyku kalitesi, yorgunluk, gündüz uykululuğu, yaşam kalitesi, depresyon ve anksiyete düzeylerini değerlendirmek için Pittsburgh Uyku Kalitesi İndeksi (PUKİ), Modifiye Yorgunluk Etki Ölçeği (MYEÖ), Epworth Uykululuk Ölçeği (EUÖ), Tercihe Dayalı Multiple Skleroz İndeksi (TDMSİ) ve Hastane Anksiyete ve Depresyon Ölçeği (HADÖ) gibi çeşitli ölçekler kullanıldı.
Bulgular: HBS, 20 katılımcıda (%27,40) tespit edildi. HBS'li ve HBS'siz MS'li bireyler arasında fiziksel, bilişsel ve toplam yorgunluk skorları ile uyku kalitesi değerlendirmesinin subjektif uyku kalitesi, uyku bozuklukları, gündüz işlev bozukluğu, uykuya dalma süresi, efektif uyku alışkanlığı alt skorları ve total PUKİ skoru açısından anlamlı farklılıklar bulundu (p<0,05). HBS şiddeti, MYEÖ-fiziksel (r=0.535), MYEÖ-toplam (r=0.494) ve PUKİ-toplam skorları ile orta derecede pozitif korelasyon gösterdi (r=0.492).
Sonuç: Bu çalışma, HBS şiddeti ile uyku kalitesi, yorgunluk ve genel yaşam kalitesi arasındaki ilişkiler hakkında yeni bilgiler sunmaktadır.
Anahtar Kelimeler
Multipl skleroz Huzursuz bacak sendromu Uyku bozuklukları Yaşam kalitesi
Kaynakça
- Hunter SF. Overview and diagnosis of multiple sclerosis. Am J Manag Care. 2016 Jun;22(6 Suppl):s141-50.
- Öztürk B, Taşkıran E, Demir S, Tuncer MA, Kürtüncü M, Karabudak R, et al. Prevalence and incidence of multiple sclerosis in Turkey: A nationwide epidemiologic study. Multiple Sclerosis Journal. 2024 Jun 14;30(7):790–9.
- Walton C, King R, Rechtman L, Kaye W, Leray E, Marrie RA, et al. Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition. Multiple Sclerosis Journal. 2020 Dec 11;26(14):1816–21.
- Ozdogar AT, Kalron A. Restless legs syndrome in people with multiple sclerosis: An updated systematic review and meta-analyses. Mult Scler Relat Disord. 2021 Nov;56:103275.
- Deriu M, Cossu G, Molari A, Murgia D, Mereu A, Ferrigno P, et al. Restless legs syndrome in multiple sclerosis: A case‐control study. Movement Disorders. 2009 Apr 15;24(5):697–701.
- Manconi M, Rocca MA, Ferini-Strambi L, Tortorella P, Agosta F, Comi G, et al. Restless legs syndrome is a common finding in multiple sclerosis and correlates with cervical cord damage. Multiple Sclerosis Journal. 2008 Jan 1;14(1):86–93.
- Douay X, Waucquier N, Hautecoeur P, Vermersch P. Prévalence élevée du syndrome des jambes sans repos dans la sclérose en plaques. Rev Neurol (Paris). 2009 Feb;165(2):194–6.
- Italian REMS Study Group, Manconi M, Ferini-Strambi L, Filippi M, Bonanni E, Iudice A, et al. Multicenter case-control study on restless legs syndrome in multiple sclerosis: the REMS study. Sleep. 2008 Jul;31(7):944–52.
- Vávrová J, Kemlink D, Šonka K, Havrdová E, Horáková D, Pardini B, et al. Restless legs syndrome in Czech patients with multiple sclerosis: An epidemiological and genetic study. Sleep Med. 2012 Aug;13(7):848–51.
- Časar Rovazdi M. Restless Legs Syndrome In Multiple Sclerosis Patients – Patient Experience Atlipik Special Hospital For Medical Rehabilitation. Acta Clin Croat. 2017;80–3.
- Seferoğlu M, Sivaci AÖ, Tunç A. Restless legs syndrome/Willis-Ekbom disease in multiple sclerosis: a contributing factor for anxiety, disability, sleep disorder, and quality of life. Arq Neuropsiquiatr. 2020 Nov;78(11):708–12.
- Cederberg KLJ, Jeng B, Sasaki JE, Braley TJ, Walters AS, Motl RW. Restless legs syndrome and health-related quality of life in adults with multiple sclerosis. J Sleep Res. 2020;29(3):e12880.
- Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983 Nov;33(11):1444–52.
- Allen RP, Picchietti DL, Garcia-Borreguero D, Ondo WG, Walters AS, Winkelman JW, et al. Restless legs syndrome/Willis-Ekbom disease diagnostic criteria: updated International Restless Legs Syndrome Study Group (IRLSSG) consensus criteria--history, rationale, description, and significance. Sleep Med. 2014 Aug;15(8):860–73.
- AY E, HELVACI YILMAZ N, ARICI DÜZ Ö, ÖZER FF. Validity and Reliability of the Turkish Version of The International Restless Legs Syndrome Study Group Rating Scale. Acta Medica Alanya. 2019 Aug 23;3(2):105–10.
- Walters AS, LeBrocq C, Dhar A, Hening W, Rosen R, Allen RP, et al. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med. 2003 Mar;4(2):121–32.
- Johns MW. A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep. 1991 Dec;14(6):540–5.
- Izci B, Ardic S, Firat H, Sahin A, Altinors M, Karacan I. Reliability and validity studies of the Turkish version of the Epworth Sleepiness Scale. Sleep and Breathing. 2008 May 6;12(2):161–8.
- Armutlu K, Keser I, Korkmaz N, Akbiyik DI, Sümbüloğlu V, Güney Z, et al. Psychometric study of Turkish version of Fatigue Impact Scale in multiple sclerosis patients. J Neurol Sci. 2007 Apr 15;255(1–2):64–8.
- Ağargün MY, Kara H, Anlar O. Pittsburgh uyku kalitesi indeksinin geçerliği ve güvenirliği. Türk Psikiyatri Dergisi. 1996;107–15.
- Buysse DJ, Reynolds CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Res. 1989 May;28(2):193–213.
- Pais Ribeiro JL, Martins da Silva A, Vilhena E, Moreira I, Santos E, Mendonça D. The hospital anxiety and depression scale, in patients with multiple sclerosis. Neuropsychiatr Dis Treat. 2018 Nov;Volume 14:3193–7.
- Aydemir O. Validity and Reliability of Turkish Version of Hospital Anxiety and Depression Scale [Internet]. Available from: https://www.researchgate.net/publication/284678404
- Kuspinar A, Mayo NE. Validation of the preference-based multiple sclerosis index. Multiple Sclerosis Journal. 2019 Oct 2;25(11):1496–505.
- Kahraman T, Özdoğar AT, Honan CA, Ertekin Ö, Özakbaş S. The multiple sclerosis work difficulties questionnaire: translation and cross-cultural adaptation to Turkish and assessment of validity and reliability. Disabil Rehabil. 2019 Oct 9;41(21):2556–62.
- Kilic S. Effect size. Journal of Mood Disorders. 2014;4(1):44.
- Akoglu H. User’s guide to correlation coefficients. Turk J Emerg Med. 2018 Sep;18(3):91–3.
- Jones KH, Ford D V., Jones PA, John A, Middleton RM, Lockhart-Jones H, et al. A Large-Scale Study of Anxiety and Depression in People with Multiple Sclerosis: A Survey via the Web Portal of the UK MS Register. PLoS One. 2012 Jul 30;7(7):e41910.
- Cederberg KLJ, Jeng B, Sasaki JE, Motl RW. Restless legs syndrome, sleep quality, and perceived cognitive impairment in adults with multiple sclerosis. Mult Scler Relat Disord. 2020 Aug;43:102176.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Nöroloji ve Nöromüsküler Hastalıklar |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Yayımlanma Tarihi | 10 Haziran 2025 |
| Gönderilme Tarihi | 4 Şubat 2025 |
| Kabul Tarihi | 19 Mart 2025 |
| Yayımlandığı Sayı | Yıl 2025Cilt: 64 Sayı: 2 |
