TUBULAR VACUOLIZATION AND ITS IMPORTANCE IN RENAL ALLOGRAFT BIOPSIES

Volume: 40 Number: 1 March 1, 2001
  • Sait Şen
  • Gülçin Başdemir
  • Hüseyin Töz
  • Cüneyt Hoşcoşkun
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TUBULAR VACUOLIZATION AND ITS IMPORTANCE IN RENAL ALLOGRAFT BIOPSIES

Abstract

Renal allograft needle biopsy (RANB) is one of the most reliable diagnostic methods. Even though some of the histopathologicat findings are specific and diagnostic, tubular epithelial cell vacuolization (TECV) is nonspecific. TECV reminds us first the cyclosporine A nephrotoxicity. But a lot of therapeutic agents and tubular ischemia may cause the same histopathologic picture. In this research, we have evaluated ten patients having TECV. We have observed TECV in RANB performed after renal allograft dysfunction following intravenous immunoglobulin (IVIG) administration in two patients, amphotericin B one patient, cyclosporine A three patients and FK506 in one. TECV was also observed in zero hour biopsies from three cadaveric donors. In one of these patients TECV was related with ischemia. In other two, we couldn't make any comment about etiology because of inadequate data of cadaveric donor. Except for the two patients, who have died, the graft dysfunction has resolved after management of etiological factors. TECV is a nonspecific finding which is frequently observed in RANB. The first etiological factor to consider is cyclosporine A. But we should also consider the other therapeutic agents, which may cause the same histopathologic picture.

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Primary Language

Turkish

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Journal Section

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Authors

Sait Şen

Gülçin Başdemir

Hüseyin Töz

Cüneyt Hoşcoşkun

Publication Date

March 1, 2001

Submission Date

March 1, 2001

Acceptance Date

-

Published in Issue

Year 2001 Volume: 40 Number: 1

IZ

https://izlik.org/JA68GN96KL

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1.Sait Şen, Gülçin Başdemir, Hüseyin Töz, Cüneyt Hoşcoşkun. RENAL GREFT BİYOPSİLERDE TÜBÜLER VAKUOLİZASYON VE ÖNEMİ. EJM [Internet]. 2001 Mar. 1;40(1):5-10. Available from: https://izlik.org/JA68GN96KL

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