ÇOCUKLUK ÇAĞI LUPUS NEFRİTİ İZLEMİNDE ANTİ-dsDNA DÜZEYİ

Sevgi Mir; Ahmet Keskinoğlu

EN TR

ANTI-dsDNA LEVELS IN THE FOLLOWUP PERIOD OF LUPUS NEPHRITIS IN CHILDHOOD

Abstract

Lupus is a chronic inflammatory disease, and characterized by the body's production of antibodies to nuclear components of the cell. It is know that Anti-dsDNA are of primary importance for diagnosis lupus nephritis (LN), appear to play a central role in the pathogenesis of tissue injury. In the study, anti-dsDNA levels and other acute phase reactans are evaluated in activity of five LN patients (mean age 14.0±0.7 years). The patients were classified according to begining of the clinical findings and renal biopsy (WHO classification criteria). Disease activity were evaluated with acute phase reactants; which were high ESR, lower C3 levels, positive ANA and compared with anti-dsDNA levels. The patients were treated with prednisone, chlorochine or cyclophosphamide according to the classification criteria. In the following period (7.0±0.7 years), there were 5 activity attacks in 4 patients. The levels of anti-dsDNA were elevated in early phase of activated LN and correlated with disease activity. In conclusion, anti-dsDNA level is an early and a good index of active lupus nephritis.

Keywords

lupus nephritis, activity, anti-dsDNA

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Sevgi Mir

Ahmet Keskinoğlu

Publication Date

March 1, 2003

Submission Date

March 1, 2003

Acceptance Date

-

Published in Issue

Year 2003 Volume: 42 Number: 1

IZ

https://izlik.org/JA84DU56DD

Cite

RIS / Bibtex

APA

Mir, S., & Keskinoğlu, A. (2003). ÇOCUKLUK ÇAĞI LUPUS NEFRİTİ İZLEMİNDE ANTİ-dsDNA DÜZEYİ. Ege Tıp Dergisi, 42(1), 19-24. https://izlik.org/JA84DU56DD

AMA

1.Mir S, Keskinoğlu A. ÇOCUKLUK ÇAĞI LUPUS NEFRİTİ İZLEMİNDE ANTİ-dsDNA DÜZEYİ. EJM. 2003;42(1):19-24. https://izlik.org/JA84DU56DD

Chicago

Mir, Sevgi, and Ahmet Keskinoğlu. 2003. “ÇOCUKLUK ÇAĞI LUPUS NEFRİTİ İZLEMİNDE ANTİ-DsDNA DÜZEYİ”. Ege Tıp Dergisi 42 (1): 19-24. https://izlik.org/JA84DU56DD.

EndNote

Mir S, Keskinoğlu A (March 1, 2003) ÇOCUKLUK ÇAĞI LUPUS NEFRİTİ İZLEMİNDE ANTİ-dsDNA DÜZEYİ. Ege Tıp Dergisi 42 1 19–24.

IEEE

[1]S. Mir and A. Keskinoğlu, “ÇOCUKLUK ÇAĞI LUPUS NEFRİTİ İZLEMİNDE ANTİ-dsDNA DÜZEYİ”, EJM, vol. 42, no. 1, pp. 19–24, Mar. 2003, [Online]. Available: https://izlik.org/JA84DU56DD

ISNAD

Mir, Sevgi - Keskinoğlu, Ahmet. “ÇOCUKLUK ÇAĞI LUPUS NEFRİTİ İZLEMİNDE ANTİ-DsDNA DÜZEYİ”. Ege Tıp Dergisi 42/1 (March 1, 2003): 19-24. https://izlik.org/JA84DU56DD.

JAMA

1.Mir S, Keskinoğlu A. ÇOCUKLUK ÇAĞI LUPUS NEFRİTİ İZLEMİNDE ANTİ-dsDNA DÜZEYİ. EJM. 2003;42:19–24.

MLA

Mir, Sevgi, and Ahmet Keskinoğlu. “ÇOCUKLUK ÇAĞI LUPUS NEFRİTİ İZLEMİNDE ANTİ-DsDNA DÜZEYİ”. Ege Tıp Dergisi, vol. 42, no. 1, Mar. 2003, pp. 19-24, https://izlik.org/JA84DU56DD.

Vancouver

1.Sevgi Mir, Ahmet Keskinoğlu. ÇOCUKLUK ÇAĞI LUPUS NEFRİTİ İZLEMİNDE ANTİ-dsDNA DÜZEYİ. EJM [Internet]. 2003 Mar. 1;42(1):19-24. Available from: https://izlik.org/JA84DU56DD