THE EFFECT OF METABOLIC CONDITION ON THE BRAIN DAMAGE RELATED TO GLOBAL ISCHEMIA AND REPERFUSION

Volume: 43 Number: 3 September 1, 2004
  • İbrahim Tuğlu
  • Kamil Vural
  • Eniz Cezayirli
  • Tuncay Varol
  • Kemal Özbılgın
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THE EFFECT OF METABOLIC CONDITION ON THE BRAIN DAMAGE RELATED TO GLOBAL ISCHEMIA AND REPERFUSION

Abstract

It is thought that ischemic preconditioning prevent the brain tissue from global ischemic damage. Hower the role of metabolic effect in the ischemic process has not yet clear. In this study, we produced global ischemia in the brain of the rats, than examined the neurological, metabolic and histological changes. In 3 months old rats, by the methods of bilateral carotid artery occlusion and hypovolemia, 48 hours after 5 minutes ischemic preconditioning following 10 min ischemia was produced. Neurological changes and arterial blood gas analysis were examined. Brain tissues of animals were stained with 2, 3, 5-triphenyletetrazolium chloride (TTC) and examined under light microscope. Rats showed ataxia and coma like symptoms. We observed the heterogeneously disseminated infarct areas, cell necrosis and edema which were independent from severity of ischemia. In our study we speculated that preventive effect of ischemic preconditioning in the damage of neuronal tissue is debate due to environmental factors. Similarity between preconditioning and ischemia groups and non-standardizations of metabolic conditions may effect these results. Future studies are required to explain metabolic effects on ischemic brain damage.

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Primary Language

Turkish

Subjects

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Journal Section

-

Authors

İbrahim Tuğlu

Kamil Vural

Eniz Cezayirli

Tuncay Varol

Kemal Özbılgın

Publication Date

September 1, 2004

Submission Date

September 1, 2004

Acceptance Date

-

Published in Issue

Year 2004 Volume: 43 Number: 3

IZ

https://izlik.org/JA83ZA38DH

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RIS / Bibtex
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1.İbrahim Tuğlu, Kamil Vural, Eniz Cezayirli, Tuncay Varol, Kemal Özbılgın. METABOLİK DURUMUN GLOBAL İSKEMİ VE REPERFÜZYONDA BEYİN HASARINA ETKİSİ. EJM [Internet]. 2004 Sep. 1;43(3):135-41. Available from: https://izlik.org/JA83ZA38DH

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