Year 2021, Volume , Issue , Pages 70 - 76 2021-01-20

Quinines and rheumatic diseases
Kininler ve romatizmal hastalıklar

Selim NALBANT [1]


Using of the quinines in rheumatic diseases for the first time is interesting as much as the adventure of the use of quinines obtained from the Cinchona tree for malaria. American soldiers with rheumatoid arthritis who were infected with malaria and treated with quinine in the Second World War were reported to have recovered from rheumatoid arthritis. Quinines, used in rheumatologic diseases, are Chloroquine, Quinacrine and Hydroxychloroquine. GIS (gastrointestinal system) absorption of antimalarials commonly used in rheumatologic diseases is very good, safe, and highly effective and longacting such as 2-3 months. Because both quinine and its hepatic metabolites are excreted from the kidney, the dose should be reduced when renal function decreases. Anti-inflammatory effects occur at many points, but which is the main mechanism is not known for today. It has hypoglycemic effects. This effect may be important in some cases. Serious side effects such as allergic skin reactions, psychosis, epilepsy-like seizures, myopathy, and retinal damage are extremely rare. More common are GIS side effects such as nausea, vomiting and dyspepsia. Ophthalmologic examination must be performed before starting treatment and control periods should be individualized in the first 5 years and after 5 years at least once a year. If the case is over 80 kg, it can be started with an initial dose of 400 mg per day. It can also be used safely when renal functions are normal during pregnancy.
Kına kına ağacından elde edilen kininlerin sıtmada kullanılmalarına ait serüven ve sonrasında olanlar ne kadar ilginç ise ilk defa romatizmal hastalıklarda kullanılmaları da o kadar ilginçtir. İkinci Dünya Savaşında sıtmaya yakalanıp kinin ile tedavi edilen romatoid artritli Amerikalı askerlerin romatoid artritlerinin iyileştiğinin fark edilmesinin, kininlerin romatizmal hastalıklarda kullanılmasına neden olduğu söylenir. Kininlerin romatolojik hastalıklarda Klorokin (Chloroquine), Kinakrin (Quinacrine) ve Hidroksiklorokin (Hydroxychloroquine) formları kullanılır. Anti-malaryaller romatolojik hastalıklarda sıklıkla kullanılan, GİS (gastrointestinal sistem) emilimi çok iyi, güvenli, oldukça etkili ve 2-3 ay gibi uzun etkili ilaçlardır. Esas olarak hem kendisi hem de hepatik metabolitleri böbrekten atıldıkları için renal fonksiyonlar azaldığında doz azaltılması gerekir. Anti-inflamatuar etkileri pek çok noktada oluşur ancak hangisi temel mekanizmadır bugün için bilinmemektedir. Hipoglisemik etkileri vardır. Bu etki bazı olgularda önemli olabilir. Alerjik cilt reaksiyonları, psikozis, epilepsi benzeri ataklar, miyopati ve retinal hasarlar gibi ciddi yan etkiler oldukça nadirdir. Daha sık görülenler bulantı-kusma ve dispepsi gibi GİS yan etkileridir. Göz kontrolü tedaviye başlamadan önce mutlaka yapılıp, ilk beş yılda kontrol periyodları bireyselleştirilmeli, beş yıldan sonra en az yılda bir yapılmalıdır. Olgu 80 kg üzerinde ise günlük 400 mg başlangıç doz ile başlanabilir. 80 kg altında 5 mg/kg doz üstüne çıkılmazsa oküler ve renal yan etkiler nadirdir. Gebelikte renal fonksiyonlar normal olduğunda güvenle kullanılabilir.
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Primary Language tr
Subjects Health Care Sciences and Services
Journal Section Case Reports
Authors

Author: Selim NALBANT (Primary Author)
Institution: Maltepe Üniversitesi Tıp Fakültesi, İç Hastalıkları Bilim Dalı, İstanbul, Türkiye
Country: Turkey


Dates

Application Date : April 6, 2020
Acceptance Date : August 28, 2020
Publication Date : January 20, 2021

Bibtex @case report { etd864171, journal = {Ege Tıp Dergisi}, issn = {1016-9113}, eissn = {2147-6500}, address = {}, publisher = {Ege University}, year = {2021}, volume = {}, pages = {70 - 76}, doi = {}, title = {Kininler ve romatizmal hastalıklar}, key = {cite}, author = {Nalbant, Selim} }
APA Nalbant, S . (2021). Kininler ve romatizmal hastalıklar . Ege Tıp Dergisi , Volume: 60 Suppl: 1 (Rheumatology) , 70-76 . Retrieved from http://egetipdergisi.com.tr/en/pub/issue/59812/864171
MLA Nalbant, S . "Kininler ve romatizmal hastalıklar" . Ege Tıp Dergisi (2021 ): 70-76 <http://egetipdergisi.com.tr/en/pub/issue/59812/864171>
Chicago Nalbant, S . "Kininler ve romatizmal hastalıklar". Ege Tıp Dergisi (2021 ): 70-76
RIS TY - JOUR T1 - Kininler ve romatizmal hastalıklar AU - Selim Nalbant Y1 - 2021 PY - 2021 N1 - DO - T2 - Ege Tıp Dergisi JF - Journal JO - JOR SP - 70 EP - 76 VL - IS - SN - 1016-9113-2147-6500 M3 - UR - Y2 - 2020 ER -
EndNote %0 Ege Tıp Dergisi Kininler ve romatizmal hastalıklar %A Selim Nalbant %T Kininler ve romatizmal hastalıklar %D 2021 %J Ege Tıp Dergisi %P 1016-9113-2147-6500 %V %N %R %U
ISNAD Nalbant, Selim . "Kininler ve romatizmal hastalıklar". Ege Tıp Dergisi / (January 2021): 70-76 .
AMA Nalbant S . Kininler ve romatizmal hastalıklar. ETD. 2021; 70-76.
Vancouver Nalbant S . Kininler ve romatizmal hastalıklar. Ege Tıp Dergisi. 2021; 70-76.
IEEE S. Nalbant , "Kininler ve romatizmal hastalıklar", Ege Tıp Dergisi, pp. 70-76, Jan. 2021